Blood gas values corrected for temperature were compared to uncorrected values in 35 cases of open heart surgery and the following results were obtained. 1) The corrected pH values were higher than the uncorrected values, and a 1 degrees C decrease in the rectal temperatures resulted in an increase pH values by 0.013(Y=-0.013x + 0.504, p<0.01). 2) The corrected values for PCO2 were lower han the uncorrected values, and a 1 degrees C decrease in the rectal temperature resulted in a decrease in corrected PCO2 values by 1.256mmHg(Y=-1.256x + 49.267, p<0.01). 3) The corrected values for PO2 were slightly lower than the uncorrected values, and the differences between temperature corrected and uncorrected PO2 values had statistically significant, but clinically no significant correlation (Y=-3.236x + 133.075, p<0.01). 4) The differences between temperature corrected and uncorrected base excess values had no satistical correlation. 5) If the uncorrected pH values were maintained around 7.4 at any temperature then the corrected pH values at each temperature were very close to the theoretically ideal values (Y=-0.014x).
Heart* ; Humans ; Hydrogen-Ion Concentration ; Hypothermia* ; Thoracic Surgery*

The incidence of C-sections has increased up to 15~20% and general anesthesia of C-sections is usually induced with thiopental or ketamin. Thiopental can produce significant fetal depression in doses higher than 4mg/kg and ketamine can cause dysphoria. The purpose of this study was to evaluate the possibility of minimizing untoward effects of both drugs by combination of the two. Sixty four pregnant women who underwent general anesthesia and C-section received thiopental 5 mg/kg(n=24); ketamine 1mg/kg(n=19); or a combination of thiopental 2.5mg/kg and ketamine 0.5mg/kg(n=21). The results were as follows: 1. At endotracheal intubation, mean arterial pressure, pulse rate, systolic blood pressure, and rate pressure product were increased from the values before anesthetic induction but there was no statistical significance among groups(p>0.05). 2. The patient's movement to the strong stimulus of skin incision and intraoperative awareness were lower in the ketamine group and higher in the combined group. 3. The induction delivery interval and uterine incision delivery interval did not differ significantly among groups. 4. The incidence of 1 and 5 min Apgar scores below 7 was highest in the thiopental group and lowest in the ketamine group. 5. Postoperative recalling of intraoperative awareness occurred in two patients only in the combined group. 6. PAR scores in the recovery room did not differ significantly among 3 groups. From the above results, the combination of thiopental and ketamine appeared to offer little advantage over thiopental or ketamine. ketamine(1mg/kg) was though to be appropriate for the induction of anesthesia for C-section with respect to the incidence of intraoperative awareness, patient's movemnet to surgical stimuli, and neonatal Apgar scores.
Anesthesia ; Anesthesia, General ; Arterial Pressure ; Blood Pressure ; Depression ; Female ; Heart Rate ; Humans ; Incidence ; Intraoperative Awareness ; Intubation, Intratracheal ; Ketamine* ; Pregnant Women ; Recovery Room ; Skin ; Thiopental*

Endotracheal intubation and tracheostomy may be an urgent, and essential procedure in cases of general anesthesia, airway obstruction, major head & neck surgery, etc, but it may cause many serious complications. The iuthors experienced a case of bilateral pneumothorax and generalized subcutaneous emphysema in a tracheostomized patient during general anesthesia with inhalation anesthetics. Herein the suthors present a case report and a review of the literature relating to the pneumothorax.
Airway Obstruction ; Anesthesia, General* ; Anesthetics, Inhalation ; Head ; Humans ; Intubation, Intratracheal ; Neck ; Pneumothorax* ; Subcutaneous Emphysema* ; Tracheostomy

Chaenomeles sinensis is known to inhibit the development and progression of many age-related diseases, but the underlying molecular mechanisms are largely unclear. In the present study, we observed that the ethanol extract of Chaenomeles sinensis scavenged 2,2’-diphenylpicrylhydrazyl and 2,2’-azinobis diammonium radicals in vitro. The ethanol extract of Chaenomeles sinensisactivated antioxidant response element-luciferase activity and induced expression of NRF2 target genes in HaCaT cells. The ethanol extract of Chaenomeles sinensis also suppressed LPS-induced expression of COX-2 and iNOS proteins, and mRNA expression of TNF-α and IL-2 in RAW264.7 cells. Finally, the ethanol extract of Chaenomeles sinensis significantly suppressed testosterone propionate-induced benign prostatic hyperplasia in mice. Together, our study provides the evidence that the ethanol extract of Chaenomeles sinensis inhibits the development of benign prostatic hyperplasia by exhibiting anti-oxidant and anti-inflammatory effects.

Background: Iliotibial band friction syndrome (ITBFS) is a common disorder of the lateral knee. Previous research has reported that the iliotibial band (ITB) thickness (ITBT) is correlated with ITBFS, and ITBT has been considered to be a key morphologic parameter of ITBFS. However, the thickness is different from inflammatory hypertrophy. Thus, we made the ITB cross-sectional area (ITBCSA) a new morphological parameter to assess ITBFS. Methods: Forty-three patients with ITBFS group and from 43 normal group who underwent T1W magnetic resonance imaging were enrolled. The ITBCSA was measured as the cross-sectional area of the ITB that was most hypertrophied in the magnetic resonance axial images. The ITBT was measured as the thickest site of ITB. Results: The mean ITBCSA was 25.24 ± 6.59 mm 2 in the normal group and 38.75 ± 9.11 mm 2 in the ITBFS group. The mean ITBT was 1.94 ± 0.41 mm in the normal group and 2.62 ± 0.46 mm in the ITBFS group. Patients in ITBFS group had significantly higher ITBCSA (P < 0.001) and ITBT (P < 0.001) than the normal group. A receiver operator characteristic curve analysis demonstrated that the best cut-off value of the ITBT was 2.29 mm, with 76.7% sensitivity, 79.1% specificity, and area under the curve (AUC) 0.88. The optimal cut-off score of the ITBCSA was 30.66 mm 2 , with 79.1% sensitivity, 79.1% specificity, and AUC 0.87. Conclusions ITBCSA is a new and sensitive morphological parameter for diagnosing ITBFS, and may even be more accurate than ITBT.

Background: Iliotibial band friction syndrome (ITBFS) is a common disorder of the lateral knee. Previous research has reported that the iliotibial band (ITB) thickness (ITBT) is correlated with ITBFS, and ITBT has been considered to be a key morphologic parameter of ITBFS. However, the thickness is different from inflammatory hypertrophy. Thus, we made the ITB cross-sectional area (ITBCSA) a new morphological parameter to assess ITBFS. Methods: Forty-three patients with ITBFS group and from 43 normal group who underwent T1W magnetic resonance imaging were enrolled. The ITBCSA was measured as the cross-sectional area of the ITB that was most hypertrophied in the magnetic resonance axial images. The ITBT was measured as the thickest site of ITB. Results: The mean ITBCSA was 25.24 ± 6.59 mm 2 in the normal group and 38.75 ± 9.11 mm 2 in the ITBFS group. The mean ITBT was 1.94 ± 0.41 mm in the normal group and 2.62 ± 0.46 mm in the ITBFS group. Patients in ITBFS group had significantly higher ITBCSA (P < 0.001) and ITBT (P < 0.001) than the normal group. A receiver operator characteristic curve analysis demonstrated that the best cut-off value of the ITBT was 2.29 mm, with 76.7% sensitivity, 79.1% specificity, and area under the curve (AUC) 0.88. The optimal cut-off score of the ITBCSA was 30.66 mm 2 , with 79.1% sensitivity, 79.1% specificity, and AUC 0.87. Conclusions ITBCSA is a new and sensitive morphological parameter for diagnosing ITBFS, and may even be more accurate than ITBT.

In this study, we investigated the inhibitory activities on gastritis and gastric ulcer using liriodendrin which is a constituent isolated from Kalopanax pictus. To elucidate its abilities to prevent gastric injury, we measured the quantity of prostaglandin E2 (PGE2) as the protective factor, and we assessed inhibition of activities related to excessive gastric acid be notorious for aggressive factor and inhibition of Helicobacter pylori (H. pylori) colonization known as a cause of chronic gastritis, gastric ulcer, and gastric cancer. Liriodendrin exhibited higher PGE2 level than rebamipide used as a positive control group at the dose of 500 microM. It was also exhibited acid-neutralizing capacity (10.3%) and H+/K+-ATPase inhibition of 42.6% (500 microM). In pylorus-ligated rats, liriodendrin showed lower volume of gastric juice (4.38 +/- 2.14 ml), slightly higher pH (1.53 +/- 0.41), and smaller total acid output (0.47 +/- 0.3 mEq/4 hrs) than the control group. Furthermore liriodendrin inhibited colonization of H. pylori effectively. In vivo test, liriodendrin significantly inhibited both of HCl/EtOH-induced gastritis (46.9 %) and indomethacin-induced gastric ulcer (46.1%). From these results, we suggest that liriodendrin could be utilized for the treatment and/or protection of gastritis and gastric ulcer.
Animals ; Colon ; Dinoprostone ; Gastric Acid ; Gastric Juice ; Gastritis ; Helicobacter pylori ; Hydrogen-Ion Concentration ; Kalopanax* ; Rats ; Stomach Neoplasms ; Stomach Ulcer