1.Comparison of Antiallodynic Effects between Intrathecal Cholinesterase Inhibitors and NMDA Antagonists on Two Neuropathic Pain Rat Models.
Keum Nae KANG ; Sun Jun CHO ; Jai Hyun HWANG
Korean Journal of Anesthesiology 2007;53(6):767-773
BACKGOUND: Cholinesterase inhibitors and N-methyl-D-aspartate (NMDA) antagonists reduce the mechanical allodynia in neuropathic pain models. In this study our aim was to compare the antiallodynic effects between intrathecal cholinesterase inhibitors and NMDA antagonists on two well-characterized neuropathic pain rat models. METHODS: Male Sprague Dawley rats were anesthetized and either had the left L5 and L6 spinal nerves ligated (SNL group) or Freund complete adjuvant (FCA) administrated to the sciatic nerve (FCA group) in order to cause neuropathic pain. A catheter was implanted into the intrathecal space for drug administration. After obtaining baseline values, edrophonium (3-100microgram), neostigmine (0.3-10microgram), AP-5 (0.3-3microgram) and MK-801 (1-30microgram) were administered intrathecally to each group. The allodynic left hind paw withdrawal thresholds to von Frey hairs were assessed and converted to % MPE. Antiallodynic effects on the two groups were compared by analyzing dose-response curves and ED 50 values. Motor weakness was also checked. RESULTS: Intrathecal edrophonium, neostigmine, AP-5 and MK-801 had a dose-dependent antiallodynic effect on the two neuropathic pain models. Comparing the antiallodynic effect dose response curves, intrathecal cholinesterase inhibitors had lower ED 50 with steep slopes in the SNL model, whereas intrathecal NMDA antagonists had lower ED 50 in the FCA model, but there were no statistically significant differences between the two models. CONCLUSIONS: Intrathecal cholinesterase inhibitors and NMDA antagonists have relatively better antiallodynic effects on the SNL and FCA neuropathic pain rat models, respectively.
Animals
;
Catheters
;
Cholinesterase Inhibitors*
;
Cholinesterases*
;
Dizocilpine Maleate
;
Edrophonium
;
Hair
;
Humans
;
Hyperalgesia
;
Male
;
Models, Animal*
;
N-Methylaspartate*
;
Neostigmine
;
Neuralgia*
;
Rats*
;
Rats, Sprague-Dawley
;
Sciatic Nerve
;
Spinal Nerves
2.Comparison of the Antiallodynic Effects of Intrathecal Lidocaine and MK-801 on Mechanical Allodynia in Two Neuropathic Pain Rat Models.
Sun Joon CHO ; Keum Nae KANG ; Jai Hyun HWANG
Korean Journal of Anesthesiology 2007;53(4):497-503
BACKGROUND: Neuropathic pain can be induced by nerve injury or inflammation. An N-methyl-D-Aspartate (NMDA) antagonist (MK-801), and a sodium channel blocker (lidocaine) have been found to reduce mechanical allodynia. This study was conducted to determine whether intrathecal lidocaine or MK-801 had an antiallodynic effect on established mechanical allodynia in two well-characterized neuropathic pain rat models. METHODS: Male Sprague Dawley rats (n = 107) were anesthetized, and the left L5 and L6 spinal nerves were ligated (SNL group) or Freund complete adjuvant (FCA) was administrated to the same spinal nerves (FCA group) in order to cause neuropathic pain. A catheter was then implanted into the lumbar intrathecal space. After obtaining the baseline scores, time-effect curves of each drug were established for the antiallodynic effects of lidocaine (30g, 100g and 300g) and MK-801 (1g, 3g, 10g and 30g). The allodynic thresholds for the left hind paw withdrawal to von Frey hairs were assessed and converted to %MPE, and the ED50 value was then calculated using the %MPE. The antiallodynic effects of the two groups were then compared by analyzing the dose-response curves and the ED50 values. RESULTS: Both intrathecal lidocaine and MK-801 resulted in a dose dependent antiallodynic effect. ED50 values and the analysis of dose response curves showed that intrathecal lidocaine provided more effective antiallodynia in the SNL group, whereas intrathecal MK-801 resulted in a greater antiallodynic effect in the FCA group. CONCLUSIONS: In the SNL group, lidocaine had a better effect in reducing allodynic pain, whereas in the FCA group, MK-801 showed a greater antiallodynic effect.
Animals
;
Catheters
;
Dizocilpine Maleate*
;
Hair
;
Humans
;
Hyperalgesia*
;
Inflammation
;
Lidocaine*
;
Male
;
Models, Animal*
;
N-Methylaspartate
;
Neuralgia*
;
Rats*
;
Rats, Sprague-Dawley
;
Sodium Channels
;
Spinal Nerves
3.Optimal Cut-Off Value of the Coracohumeral Ligament Area as a Morphological Parameter to Confirm Frozen Shoulder
Hyung Rae CHO ; Byong Hyon CHO ; Keum Nae KANG ; Young Uk KIM
Journal of Korean Medical Science 2020;35(15):e99-
Background:
Thickened coracohumeral ligament (CHL) is one of the important morphological changes of frozen shoulder (FS). Previous research reported that coracohumeral ligament thickness (CHLT) is correlated with anterior glenohumeral instability, rotator interval and eventually FS. However, thickness may change depending on the cutting angle, and measurement point. To reduce measurement mistakes, we devised a new imaging criteria, called the coracohumeral ligament area (CHLA).
Methods:
CHL data were collected and analyzed from 52 patients with FS, and from 51 control subjects (no evidence of FS). Shoulder magnetic resonance imaging was performed in all subjects. We investigated the CHLT and CHLA at the maximal thickened view of the CHL using our picture archiving and communications system. The CHLA was measured as the whole area of the CHL including the most hypertrophied part of the MR images on the oblique sagittal plane. The CHLT was measured at the thickest point of the CHL.
Results:
The average CHLA was 40.88 ± 12.53 mm2 in the control group and 67.47 ± 19.88 mm2 in the FS group. The mean CHLT was 2.84 ± 0.67 mm in the control group and 4.01 ± 1.11 mm in the FS group. FS patients had significantly higher CHLA (P < 0.01) and CHLT (P < 0.01) than the control group. The receiver operator characteristic analysis showed that the most suitable cut-off score of the CHLA was 50.01 mm2, with 76.9% sensitivity, 76.5% specificity, and area under the curve (AUC) of 0.87. The most suitable cut-off value of the CHLT was 3.30 mm, with 71.2% sensitivity, 70.6% specificity, and AUC of 0.81.
Conclusion
The significantly positive correlation between the CHLA, CHLT and FS was found. We also demonstrate that the CHLA has statistically equivalent power to CHLT. Thus, for diagnosis of FS, the treating physician can refer to CHLA as well as CHLT.
4.Ultrasound-guided Pulsed Radiofrequency Lesioning of the Phrenic Nerve in a Patient with Intractable Hiccup.
Keum Nae KANG ; In Kyung PARK ; Jeong Hun SUH ; Jeong Gill LEEM ; Jin Woo SHIN
The Korean Journal of Pain 2010;23(3):198-201
Persistent and intractable hiccups (with respective durations of more than 48 hours and 1 month) can result in depression, fatigue, impaired sleep, dehydration, weight loss, malnutrition, and aspiration syndromes. The conventional treatments for hiccups are either non-pharmacological, pharmacological or a nerve block treatment. Pulsed radiofrequency lesioning (PRFL) has been proposed for the modulation of the excited nervous system pathway of pain as a safe and nondestructive treatment method. As placement of the electrode in close proximity to the targeted nerve is very important for the success of PRFL, ultrasound appears to be well suited for this technique. A 74-year-old man suffering from intractable hiccups that had developed after a coronary artery bypass graft and had continued for 7 years was referred to our pain clinic. He had not been treated with conventional methods or medications. We performed PRFL of the phrenic nerve guided by ultrasound and the hiccups disappeared.
Aged
;
Coronary Artery Bypass
;
Dehydration
;
Depression
;
Electrodes
;
Fatigue
;
Hiccup
;
Humans
;
Malnutrition
;
Nerve Block
;
Nervous System
;
Pain Clinics
;
Phrenic Nerve
;
Stress, Psychological
;
Transplants
;
Weight Loss
5.Concurrent meralgia paresthetica and radiculopathy of the left leg: A case report.
Keum Nae KANG ; Chang Joon RHYU ; Sung Won CHON ; Young Soon CHOI ; Jee In YOO ; Young Su LIM ; Yun Sic BANG ; Young Uk KIM
Anesthesia and Pain Medicine 2017;12(1):81-84
Meralgia paresthetica (MP) is a painful mononeuropathy of the lateral femoral cutaneouse nerve (LFCN) characterized by localized symptoms of numbness, tingling, pain and paresthesia along the anterolateral thigh area. L4 and L5 radiculopathy is set of symptoms that include sharp, burning or shooting pain, which is usually localized to anterolateral leg area and along the dermatomal distribution. When symptoms of MP and lumbar disc disease occur together it is not easy to diagnose MP. We report a case of synchronous post-traumatic MP and radiculopathy due to intervertebral disc herniation at L3–4 and 4–5. A 59-year-old male patient was admitted to the emergency room with symptoms of low back pain with left severe L4, L5 radiculopathy. This patient also complained of numbness and paresthesia in the left anterolateral thigh. After detailed history taking and lateral femoral cutaneouse nerve block, he was diagnosed with MP.
Burns
;
Emergency Service, Hospital
;
Humans
;
Hypesthesia
;
Intervertebral Disc
;
Leg*
;
Low Back Pain
;
Male
;
Middle Aged
;
Mononeuropathies
;
Nerve Block
;
Paresthesia
;
Radiculopathy*
;
Thigh
6.Pulmonary Embolism in a Patient of Renal Cell Carcinoma with Inferior Vena Cava Thrombus : A case report.
Hee Yeong KIM ; Gyu Sam HWANG ; Young Kug KIM ; In Cheol CHOI ; Keum Nae KANG ; Jai Hyun HWANG
Anesthesia and Pain Medicine 2007;2(3):172-176
Renal cell carcinoma (RCC) involves frequently the inferior vena cava (IVC). As effective treatment of RCC with IVC thrombus is currently lacking, aggressive surgical treatment may be considered. However, this procedure can result in fatal complications such as pulmonary embolism. We experienced a case of pulmonary embolism diagnosed, not by intraoperative transesophageal echocardiography, but by a computed tomography scan taken just after radical nephrectomy with IVC thrombectomy in a 63-year-old patient with RCC extending to the IVC.
Carcinoma, Renal Cell*
;
Echocardiography, Transesophageal
;
Embolism
;
Humans
;
Middle Aged
;
Nephrectomy
;
Pulmonary Embolism*
;
Thrombectomy
;
Thrombosis*
;
Vena Cava, Inferior*
7.Inadvertent Breakage of the Spinal Needle during the Obturator Nerve Block for the Transurethral Resection of Bladder Tumor: A case report.
Ji Hyun CHIN ; In Gu JUN ; Young Kug KIM ; Keum Nae KANG ; Gyu Sam HWANG ; Jai Hyun HWANG
Korean Journal of Anesthesiology 2007;53(2):250-253
Obturator nerve block is occasionally performed during transurethral resection of lateral bladder wall tumors to prevent the violent contraction of the adductor muscle of the thigh. Rare complications including intravascular injection of the local anesthetics and hematoma formation may occur during the obturator nerve block. We report a case of the unintentional breakage of the spinal needle during the obturator nerve block with successful removal of the broken spinal needle by an orthopedic surgeon.
Anesthetics, Local
;
Hematoma
;
Needles*
;
Obturator Nerve*
;
Orthopedics
;
Thigh
;
Urinary Bladder Neoplasms*
;
Urinary Bladder*
8.Entrapment and cutting of a pulmonary artery catheter : Two cases report.
Hae Young RYU ; Myung Hee SONG ; Keum Nae KANG ; Eun Ho LEE ; In Cheol CHOI
Anesthesia and Pain Medicine 2009;4(3):242-245
Case 1:A 59-year-old man underwent mitral valve replacement and Maze operation.Under general anesthesia, a pulmonary artery catheter (PAC) and superior vena cava (SVC) cannula were inserted.There were no complications during surgery.However, when the surgeons attempted to remove the PAC the next day there was resistance that caused the catheter to break during removal.A chest X ray revealed that the distal portion of the PAC remained in his heart.Therefore, the patient underwent surgery to remove the remnant catheter.Case 2:A 62-year-old man underwent mitral valvuloplasty.A PAC was inserted under general anesthesia.After the procedure, the patient was weaned off his cardiopulmonary bypass (CPB).However, his pulmonary artery pressure could not be measured and an abnormal wave was observed. We attempted to re-insert the catheter, but were unsuccesful.An operation was conducted and the catheter was found to be tied at the septum of the right atrium.
Anesthesia, General
;
Cardiopulmonary Bypass
;
Catheters
;
Humans
;
Middle Aged
;
Mitral Valve
;
Pulmonary Artery
;
Thorax
;
Vena Cava, Superior
9.Entrapment and cutting of a pulmonary artery catheter : Two cases report.
Hae Young RYU ; Myung Hee SONG ; Keum Nae KANG ; Eun Ho LEE ; In Cheol CHOI
Anesthesia and Pain Medicine 2009;4(3):242-245
Case 1:A 59-year-old man underwent mitral valve replacement and Maze operation.Under general anesthesia, a pulmonary artery catheter (PAC) and superior vena cava (SVC) cannula were inserted.There were no complications during surgery.However, when the surgeons attempted to remove the PAC the next day there was resistance that caused the catheter to break during removal.A chest X ray revealed that the distal portion of the PAC remained in his heart.Therefore, the patient underwent surgery to remove the remnant catheter.Case 2:A 62-year-old man underwent mitral valvuloplasty.A PAC was inserted under general anesthesia.After the procedure, the patient was weaned off his cardiopulmonary bypass (CPB).However, his pulmonary artery pressure could not be measured and an abnormal wave was observed. We attempted to re-insert the catheter, but were unsuccesful.An operation was conducted and the catheter was found to be tied at the septum of the right atrium.
Anesthesia, General
;
Cardiopulmonary Bypass
;
Catheters
;
Humans
;
Middle Aged
;
Mitral Valve
;
Pulmonary Artery
;
Thorax
;
Vena Cava, Superior
10.The role of the iliotibial band cross-sectional area as a morphological parameter of the iliotibial band friction syndrome:a retrospective pilot study
Jiyeon PARK ; Hyung Rae CHO ; Keum Nae KANG ; Kun Woong CHOI ; Young Soon CHOI ; Hye-Won JEONG ; Jungmin YI ; Young Uk KIM
The Korean Journal of Pain 2021;34(2):229-233
Background:
Iliotibial band friction syndrome (ITBFS) is a common disorder of the lateral knee. Previous research has reported that the iliotibial band (ITB) thickness (ITBT) is correlated with ITBFS, and ITBT has been considered to be a key morphologic parameter of ITBFS. However, the thickness is different from inflammatory hypertrophy. Thus, we made the ITB cross-sectional area (ITBCSA) a new morphological parameter to assess ITBFS.
Methods:
Forty-three patients with ITBFS group and from 43 normal group who underwent T1W magnetic resonance imaging were enrolled. The ITBCSA was measured as the cross-sectional area of the ITB that was most hypertrophied in the magnetic resonance axial images. The ITBT was measured as the thickest site of ITB.
Results:
The mean ITBCSA was 25.24 ± 6.59 mm 2 in the normal group and 38.75 ± 9.11 mm 2 in the ITBFS group. The mean ITBT was 1.94 ± 0.41 mm in the normal group and 2.62 ± 0.46 mm in the ITBFS group. Patients in ITBFS group had significantly higher ITBCSA (P < 0.001) and ITBT (P < 0.001) than the normal group. A receiver operator characteristic curve analysis demonstrated that the best cut-off value of the ITBT was 2.29 mm, with 76.7% sensitivity, 79.1% specificity, and area under the curve (AUC) 0.88. The optimal cut-off score of the ITBCSA was 30.66 mm 2 , with 79.1% sensitivity, 79.1% specificity, and AUC 0.87.
Conclusions
ITBCSA is a new and sensitive morphological parameter for diagnosing ITBFS, and may even be more accurate than ITBT.