The traditional aesthetic blepharoplasty has limitations in correcting the heaviness and bulkiness of the lateral orbital region. These limitation is due to presence of sub-orbicularis oculus fat(SOOF) which is defined as that layer of fibrofatty soft tissue deep to the orbicularis oculus muscle, superficial to orbital septum and orbital rim, and extending medially from supraorbital nerve and laterally to varying distance over the lateral upper orbit. Therefore authors performed resections of the SOOF in conjunction with aesthetic blepharoplasty in 15 patients, who visited the clinic with complaints of thickness and heaviness over their lateral eyebrow, often accompanied by tired or sad-looking appearance. We believe that in these patients the heaviness. bulkiness and fullness in the lateral upper orbital region were corrected effectively and smoothly in aesthetical aspect. No patients developed postoperative hematoma, dry eye syndrome, lacrimal gland injury and significant paralysis of the orbicularis oculus of corrugator muscle. Our department performed the SOOF resection to those who had bulkiness and heaviness in lateral upper orbital region. From this experience, the SOOF resection would appear to be a useful adjunct to standard blepharoplasty technique in selected patients. Since we achieved a satisfactory result aesthetically through this method on patients who showed proper indications, we are recording the indications, operative techniques and complications in addition to review of reference.
Blepharoplasty* ; Dry Eye Syndromes ; Eyebrows ; Hematoma ; Humans ; Lacrimal Apparatus ; Orbit ; Paralysis

Benign Prostatic Hyperplasia is one of the most important desease with a high frequency in urology. There is no doubt that the main stream of treatment is transurethral resection. of the prostate, however, marked improvement in drug therapy has been observed in recent years. Allylestrenol is a synthetic gestagen which was known to act directly on the prostate to exhibit its effect of reducing the size of the prostate by inhibiting the selective uptake of serum testosterone, inhibition of metabolism of testosterone to 5a-DHT (dihydrotestosterone) reductase, inhibition of 5a-DHT receptor binding. Our present study was carried out on 108 patients with benign prostatic hyperplasia to evaluate the efficacy and safety of antiandrogen therapy with allylestrenol. Allylestrenol was administered in a dose of 25 mg twice a day in the morning and evening after meal for 12 weeks to the patients and its efficacy was evaluated with peak urinary flow rate, Madsen Symptom Score at 4, 12 weeks after treatment and prostate volume at 12 weeks after treatment. Of these patients 46 completed the study and only 2 patients withdrew from the study owing to side effects. However,these side effects were not serious. At baseline (mean +SD) the mean peak urinary flow rate was 11.0+/-3.7 ml/sec, mean symptom score 10.2+4.0 and mean ultrasonic assessment of prostatic volume 36.8 +/-9.6 gm. At 4 weeks after treatment(mean + SD) mean peak urinary flow rate was 12+/-3.5 ml/sec, mean symptom score 7.7+/-4.2 (p > .0.05, p < 0.05). At 12 weeks after treatment (mean +SD) mean peak urinary flow rate was 12.8+4.7 ml/sec, mean symptom score 7.0+4.2 and mean ultrasonic assessment of prostatic volume 36.6+/-9.3 gm (p < 0.05, p < 0.05, p > 0.05).
Allylestrenol* ; Drug Therapy ; Humans ; Meals ; Metabolism ; Oxidoreductases ; Prostate ; Prostatic Hyperplasia* ; Rivers ; Testosterone ; Ultrasonics ; Urology

Pheochromocytoma is one of the surgically curable hypertensive diseases and can arise wherever chromaffin cells are located. Herein, a case of extra-adrenal pheochromocytoma developed in a 51 year-old male is presented with brief review of literatures.
Chromaffin Cells ; Humans ; Male ; Middle Aged ; Pheochromocytoma*

BACKGROUND: To date there has not been a study of the histologic data of hair pollicles in scalp hairs of healthy Korean female adults. It is better to evaluate follicular structures in horizontal histologic sectioning than in vertical sectioning. OBJECTIVE: To obtain histologic data of hair follicles in scalp hairs in healthy Korean female adults. METHODS: 20 healthy Korean female volunteers with a normal scalp were analyzed. The age range was 22~29 years (mean 25.7+/-2.3). Transverse sections of 4 mm punch biposy specimens from the vertex were examined at various levels from the papillary dermis to the subcutis. Follicular counts of terminal/vellus hairs and anagen/ telogen hair were evaluated. RESULTS: The total number of total hairs, terminal hairs, vellus hairs, average follicular units, and follicular structures/ mm(2) were 17.5+/-2.6, 15.8+/-2.5, 1.8+/-0.7, 9.0+/-1.6, and 1.4+/-0.2 respectively. Terminal hair:vellus hair ratio was 9:1 and percentage of anagen hairs among total hairs was 95%. Hair density in Korean female was found be significantly lower than that of white females and African American females. CONCLUSION: This data can be used as a guideline for interpreting transverse sections of scalp biopsy specimens in Korean female adults.
Adult ; Biopsy ; Dermis ; Female ; Hair ; Hair Follicle ; Humans ; Scalp

BACKGROUND: The advantage of transverse sectioning over vertical sectioning of scalp biopsies is morphometric analysis of follicular structures. OBJECTIVE: To obtain histologic data of hair follicles from normal scalp hair in a Korean male. METHOD: A total of 22 Korean male volunteers with a normal scalp were included. The age range was 26+/-4.5 (23-29 year-old). Transverse sections of 4mm punch biopsy specimens from the vertex were examined at various levels from the papillary dermis to the subcutis. Follicular counts of terminal/vellus hairs and anagen/telogen hairs were evaluated. RESULTS: The number of total hairs, terminal hairs, vellus hairs, average follicular units, and follicular structures/mm2 were 21.2+/-4.1, 18.8+/-3.7, 2.4+/-1.4, 9.0+/-1.6, and 1.6+/-0.3, respectively. Terminal hair: vellus hair ratio and anagen: telogen hair ratio were 7.8: 1 and 93.7: 6.3, respectively. Hair density in Korean males was found be significantly lower than that of white males, but similar to that of black males. CONCLUSION: This data can be used as a guideline for interpreting transverse sections of scalp biopsy specimens in Korean males.
Biopsy ; Dermis ; Hair ; Hair Follicle ; Humans ; Male* ; Scalp* ; Volunteers

Bacillus Calmette-Guerin (BCG) is an attenuated strain of Mycobacterium bovis (M. bovis) that has been used to treat transitional cell carcinoma. Since the initial report by Morales and associates on the use of intravesical BCG for the treatment of recurrent superficial bladder tumors, intravesical therapy with BCG has proved to be more effective for prophylaxis and the treatment of superficial bladder tumors and carcinoma in situ than most of the standard chemotherapeutic agents. While the majority of patients tolerate BCG treatments well, a number of adverse reaction (e.g., fever, hematuria, dysuria, nausea and malaise) have been reported. More serious complications occur on rare occasions and they include pneumonitis/hepatitis, ureteral obstruction, renal abscess and sepsis. We report here on a case of ureteral obstruction that was caused by periureteral tuberculous granuloma after intravesical BCG therapy for superficial bladder tumors, and the condition required distal ureterectomy & ureteroneocystostomy.
Abscess ; Bacillus ; Carcinoma in Situ ; Carcinoma, Transitional Cell ; Dysuria ; Fever ; Granuloma* ; Hematuria ; Humans ; Morale ; Mycobacterium bovis* ; Nausea ; Sepsis ; Ureter* ; Ureteral Obstruction* ; Urinary Bladder Neoplasms* ; Urinary Bladder*

BACKGROUND: A standardized reference method for dermatophytes in vitro susceptibility testing is lacking. However, with increasing variety of drugs available to treat dermatophytosis, the need for a reference method for dermatophytes testing has become apparent. OBJECTIVE: To evaluate a method of quantifying dermatophytes, the standards for broth microdilution method and evaluation of the availability of disk diffusion method in antifungal susceptibility testing for dermatophytes. METHODS: 14 Candida species (sp.), 30 Trichophyton(T.) mentagrophytes, 9 T. raubitschekii and 11 T. rubrum were tested for fluconazole susceptibility by the broth microdilution method and disc diffusion method. Candida sp. was tested according to National Committee for Clinical Laboratory Standards (NCCLS) M27-A and M44-A. Broth microdilution method for T. mentagrophytes, T. raubitschekii and T. rubrum was operated according to NCCLS M38-A. Disk diffusion method for T. mentagrophytes, T. raubitschekii and T. rubrum was tested refer to NCCLS M44-A. RESULTS: The disk diffusion method showed 50% correlation rate with the broth microdilution method for antifungal susceptibility testing for Candida species. The MIC reading point and incubation time of the broth microdilution method for T. mentagrophytes, T. raubitschekii and T. rubrum are Spec-50 and from 7, 6 and 9 days. Relation between the broth microdilution method and disk diffusion method for dermatophytes is poor. CONCLUSIONS: The good method for quantifying dermatophytes is using vortexing only or liquid nitrogen and homogenizer. Standards of MIC reading point and incubation time of microdilution method for dermatophytes are Spec-50 and from 6 to 9 days. It appears that the disk diffusion method is not recommended method for the antifungal susceptibility testing of dermatophytes.
Arthrodermataceae ; Candida ; Diffusion ; Fluconazole ; Nitrogen ; Tinea

PURPOSE: The aim of this study is to explore the role of human adipose tissue-derived adult stem cells (ASCs) in repair of acute ischemic renal injury. METHODS: Acute ischemic tubular necrosis was induced in Spraque-Dawley rats (n=15) by clamping bilateral renal pedicles for 40 minutes. Before releasing the clamps, iron labeled stem cells (1x106/0.3 mL) were directly injected to one side of renal cortex and phosphate-buffered saline (PBS) injections were done as a control to the opposite kidney. The examination on both kidney was done after 1, 2 and 4 weeks (n=5 each). The evaluation of the degree of tubular necrosis and the location of stem cells was done by light and electron microscopically. RESULTS: The rats were all alive without rejection. Morphologically, recovery rate was increased up to about 20% in ASCs injection group in 2 weeks-group (p<0.001). Few Prussian-blue positive cells were demonstrated in 2 weeks-group and more cells were present in 4 weeks-group. The cells which were positively stained in Prussian-blue stain were mainly located in peritubular spaces. Electron microscopically, fine iron granules with electron density were found in the cytoplasm of peritubular endothelial cells. CONCLUSION: As a result, the endothelial cells might be differentiated from injected ASCs. It seems that stem cells help repairing the tubular epithelium in acute renal failure model, not by tubulogenesis but by vasculogenesis. This outcome suggests that the possibility of therapeutic use of ASCs without immunosuppression of recipients in acute ischemic renal injury.
Acute Kidney Injury ; Adult Stem Cells ; Animals ; Constriction ; Cytoplasm ; Electrons ; Endothelial Cells ; Epithelium ; Humans ; Immunosuppression ; Iron ; Kidney ; Light ; Mesenchymal Stromal Cells ; Necrosis ; Rats ; Rejection (Psychology) ; Stem Cells

OBJECTIVE: To investigate the changes of intraarticular temperature in the knee according to the application methods of cold jet-stream and to find the more effective method which reduces the intraarticular temperature. METHOD: Fifteen healthy subjects were examined. We recorded both skin and intraarticular temperature of the knee for 120 minutes. We compared two different cooling methods using -30 degrees C cold jet-stream by CRAis(R) (Century, Korea). The first was the intermittent cold jet-stream application method (ICA) which applied cold jet-stream to the knee joint every other minute for 5 minutes and the second was the continuous cold jet-stream application method with infrared (CCAI) for 5 minutes. RESULTS: In ICA, the intraarticular temperature maximally dropped as 1.7+/-0.6 degrees C (p<0.01) and it took 28.7+/-18.9 minutes. Intraarticular temperature dropped 0.6+/-0.5 degrees C after 2 hour (p<0.05). In CCAI, the intraarticular temperature maximally dropped as 2.8+/-0.7 degrees C (p<0.01) and it took 38.0+/-24.6 minutes, intraarticular temperature after 2 hour dropped as 1.36+/-0.75 degrees C (p<0.05). According to the two methods, CCAI showed more reduction in the lowest and after 2 hour intraarticular temperature compared with ICA in the knee joint (p<0.05). CONCLUSION: CCAI is better for reducing the intraarticular temperature than ICA.
Knee Joint* ; Knee* ; Skin ; Skin Temperature

BACKGROUND: Acellular dermal matrix (ADM) helps wound healing by stimulating angiogenesis, acting as a chemoattractant for endothelial cells, providing growth factors, and permitting a substrate for fibroblasts to attach. The current standard for using paste-type ADM (CG Paste) in wound healing is direct application over the wounds. The major concerns regarding this method are unpredictable separation from the wounds and absorption into negative-pressure wound therapy devices. This study aimed to investigate the effects of subcutaneous injection of paste-type ADM on wound healing in rats. METHODS: Full-thickness skin defects were created on the dorsal skin of rats. Eighteen rats were randomly divided into three groups and treated using different wound coverage methods: group A, with a saline dressing; group B, standard application of CG Paste; and group C, injection of CG Paste. On postoperative days 3, 5, 7, 10, and 14, the wound areas were analyzed morphologically. Histological and immunohistochemical tissue analyses were performed on postoperative days 3 and 7. RESULTS: Groups B and C had significantly less raw surface than group A on postoperative days 10 and 14. Collagen fiber deposition and microvessel density were significantly higher in group C than in groups A and B on postoperative days 3 and 7. CONCLUSIONS: This study showed comparable effectiveness between subcutaneous injection and the conventional dressing method of paste-type ADM. Moreover, the injection of CG Paste led to improved wound healing quality through the accumulation of collagen fibers and an increase in microvessel density.
Absorption ; Acellular Dermis* ; Animals ; Bandages ; Collagen ; Endothelial Cells ; Fibroblasts ; Injections, Subcutaneous* ; Intercellular Signaling Peptides and Proteins ; Methods ; Microvessels ; Negative-Pressure Wound Therapy ; Ointments ; Rats ; Skin ; Wound Healing* ; Wounds and Injuries*