No abstract available.
Ketoprofen*

The in vitro release of Ketoprofen from different ointment bases at 2.5% concentration was studied. The rank order of the release pass dialysis membrane was as follow: emugel (used solid dispersion system with  - cyclodextrin) PEG ointments > carbopol 934, CMC, HPMC gel > emulsified ointment > absorption ointment > hydrophobic ointment
Ointments ; Ketoprofen

Capillary Zone Electrophoresis (CZE) was used to quantify ketoprofen in 50mg ketoprofen capsules and ketoprofen gel 2.5%. The results were compared to results of spectrophotometric UV-VIS method. Results: the accuracies of 2 methods were different but not significant. Results of CZE method were rather lower than spectrophotometric UV-VIS method because impurities were separated in electrophoresis process. The authors concluded that CZE could be used to quantify ketoprofen in products
Ketoprofen ; Electrophoresis ; Adjuvants, Pharmaceutic

To obtain a prolonged-action dosage form of Ketoprofen, a technique for delaying drug release from insoluble inert matrix of ethyl cellulose was evaluated. It was incorporated with excipients such as lactose, starch, hydroxy propyl methyl cellulose. influence of lubricants on release profiles was also investigated. The best result was obtained from the formula that consists of ethyl cellulose, lactose, starch, hydroxy propyl methyl cellulose, magnesium stearate, talc, aerosil (appropriate rate) and is coated with Eudragit L 100 (1mg/cm2)
Ketoprofen ; Cyclooxygenase Inhibitors ; tablets ; Pharmaceutical Preparations

Acetonitril was used to extract ketoprofen from plasma. The revese phase HPLC was carried out with UV detector at 253nm column Nucleosil ODS 5m (4,6*250 mm); mobile phase: MeCN: AcOH: Triethylamin: H2O (50: 0.5: 0.3: 48.7 v/v); flow rate 0.85 ml/min. Experimental results proved that the method was stable, accurate and precise
Plasma ; Ketoprofen ; Chromatography, High Pressure Liquid

In this study, gel ketoprofen, which has been used as an non-steroidal anti-inflammatory agent, was standardized on appearance, weight uniformity, pH, particulate matter, viscosity, identification, and assay. By using UV spectrophotometry, ketoprofen was quantified using methanol as its solvent. This method was accurate, sensitive, precise, and reproducible
Anti-Inflammatory Agents ; Ketoprofen ; Pharmaceutical Preparations

In vitro bioavailability of ketoprofen 200mg long acting tablets by the oral were studied. Using basket dissolution tester at 120rpm. Released ketoprofen was determined by a UV – spectrophotometer at 260nm. Ketoprofen plasma levels on carefully chosen 6 healthy volunteers were within treatment which reached from 4 to 36 hours. 200mg ketoprofen LP tablets gradually released ketoprofen within 24 hours and released about 80% after 18 hours. Pharmacological parameter of ketoprofen 200mg long acting tablets have the same value compared with the results which have been published
Biological Availability ; Pharmaceutical Preparations ; Ketoprofen ; tablets ; drugs

Ketoprofen gel is a medical product used to treat musculoosteoarthropathy. Establishing process to make up gel product achieve pharmaceutical quality criteria by formula to create gel product, optimized formula by defined experimentation, investigated about abilities released ketoprifen through membrane compared profenid gel, investigated upset ability of product, then estimated pharmaceutical effect of gel. Initially we investigated stabilization of the products in natural environment, and predicted life-span of the drug is 27 months similar a imported product
Ketoprofen ; Manufactured Materials ; Cosmetic Techniques ; drugs

BACKGROUND: Epidural administration of dexamethasone has been suggested for pain control after minor orthopedic surgery. This study was conducted to assess its efficacy after such surgery, combined or not to IV dipyrone, IV parecoxibe or their combination. METHODS: 91 patients were randomly assigned to seven groups. Patients were submitted to spinal bupivacaine anesthesia combined to epidural administration of either 10 ml saline or 10 mg dexamethasone diluted to 10-ml volume. Patients also received 10 ml IV saline or 1 gr dipyrone and/or 40 mg parecoxibe diluted to 10 ml with saline. Control group (CG) received epidural and IV saline. Dexamethasone group (DexG) received epidural dexamethasone and IV saline. Dipyrone group (DipG) received epidural saline and IV dipyrone. Dex-Dip G received epidural dexamethasone and IV dipyrone. Parecoxibe group (ParG) received epidural saline and IV parecoxibe. Dex-ParG received epidural dexamethasone and IV parecoxibe. Finally, Dex-Dip-ParG received epidural dexamethasone and IV dipyrone plus IV parecoxibe. RESULTS: The CG expressed 4h of analgesia and sooner requested pain killer. DexG was similar to DipG or ParG or Dex-ParG (7-hours), and they requested less ketoprofen compared to the CG (P < 0.05). However, the Dex-DipG and the Dex-Dip-ParG resulted in longer time to demand pain killer (17-hours) and less ketoprofen consumption in 24-hours (P < 0.002). Adverse effects were similar among groups. CONCLUSIONS: The analgesia secondary to epidural dexamethasone was enhanced by IV dipyrone, while no effects were observed by the addition of IV parecoxibe.
Analgesia* ; Anesthesia ; Bupivacaine ; Dexamethasone* ; Dipyrone* ; Humans ; Ketoprofen ; Orthopedics* ; Pain, Postoperative

BACKGROUND: Epidural administration of dexamethasone has been suggested for pain control after minor orthopedic surgery. This study was conducted to assess its efficacy after such surgery, combined or not to IV dipyrone, IV parecoxibe or their combination. METHODS: 91 patients were randomly assigned to seven groups. Patients were submitted to spinal bupivacaine anesthesia combined to epidural administration of either 10 ml saline or 10 mg dexamethasone diluted to 10-ml volume. Patients also received 10 ml IV saline or 1 gr dipyrone and/or 40 mg parecoxibe diluted to 10 ml with saline. Control group (CG) received epidural and IV saline. Dexamethasone group (DexG) received epidural dexamethasone and IV saline. Dipyrone group (DipG) received epidural saline and IV dipyrone. Dex-Dip G received epidural dexamethasone and IV dipyrone. Parecoxibe group (ParG) received epidural saline and IV parecoxibe. Dex-ParG received epidural dexamethasone and IV parecoxibe. Finally, Dex-Dip-ParG received epidural dexamethasone and IV dipyrone plus IV parecoxibe. RESULTS: The CG expressed 4h of analgesia and sooner requested pain killer. DexG was similar to DipG or ParG or Dex-ParG (7-hours), and they requested less ketoprofen compared to the CG (P < 0.05). However, the Dex-DipG and the Dex-Dip-ParG resulted in longer time to demand pain killer (17-hours) and less ketoprofen consumption in 24-hours (P < 0.002). Adverse effects were similar among groups. CONCLUSIONS: The analgesia secondary to epidural dexamethasone was enhanced by IV dipyrone, while no effects were observed by the addition of IV parecoxibe.
Analgesia ; Anesthesia ; Bupivacaine ; Dexamethasone ; Dipyrone ; Humans ; Ketoprofen ; Orthopedics ; Pain, Postoperative