1.NADPH oxidase and cerebral ischemia-reperfusion injury
Li ZHANG ; Ketan CHU ; Benyan LUO
International Journal of Cerebrovascular Diseases 2012;20(6):465-467
NADPH oxidases are a family of multi-subunit enzyme eomplexes.It catalyzes the production of reactive oxygen species (ROS).A large number of studies have shown that oxidative stress plays a very important role in cerebral ischemia-reperfusion injury,and the find of the expression changes about NADPH oxidase after cerebral ischemia may provide a new idea for the prevention and treatment of ischemic stroke.NADPH oxidase may become a new therapeutic target.
2.Upregulation of h-TERT and Ki-67 in ectopic endometrium is associated with recurrence of endometriosis.
Jie LUO ; Zhimin SONG ; Tao ZHANG ; Ketan CHU ; Jingyi LI ; Jianhong ZHOU ; Jun LIN
Journal of Zhejiang University. Science. B 2022;23(2):158-163
At present, endometriosis remains a worldwide health burden, with the main symptoms of dysmenorrhea, chronic pelvic pain, and infertility, markedly reducing the quality of life (de Ziegler et al., 2010). Although there is no proof that the disease is associated with high mortality, this disorder can significantly contribute to the deterioration of women's general well-being (McPeak et al., 2018). The main current treatment for endometriosis is surgery to remove endometriotic lesions; however, the recurrence rate following surgical treatment is as high as 21.5% at two years and 40.0%-50.0% at five years post-surgery (Koga et al., 2015). To prevent recurrence, adjuvant treatment with drugs after surgery is recommended to prolong relapse-free intervals. However, it is inconvenient for patients to continuously use such medications in terms of adverse effects and cost (Turk, 2002).
Endometriosis/pathology*
;
Endometrium/pathology*
;
Female
;
Humans
;
Ki-67 Antigen/metabolism*
;
Quality of Life
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Recurrence
;
Telomerase/metabolism*
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Up-Regulation