BACKGROUND: College students of normal universities, the major supply of teachers, have influences on their latter career of teacher man.OBJECTIVE: To investigate the mental health of freshmen of local normal university in 2005, so as to provide the basis for mental health education and mental counselling.DESIGN: Cluster sampling and cross-sectional investigation.SETTING: Department of Education Science, Hengyang Normal University.PARTICIPANTS: This experiment was carried out in Hengyang Normal University in October 2005. Totally 3 089 freshmen of Hengyang Normal University in 2005 were selected as the participants, including 1 211 male and 1878 female with the mean age of 18.72 years.METHODS: The freshmen were tested by Symptom Check List- 90 (SCL-90)in groups after their enrolment a month later. Before answering the questions, they were given uniform directions and answered every question individually according to their own conditions in the latest week. All the answer papers were handed in on the spot. The data of SCL-90 were inputwith Optical Mark Reader 2000 (OMR2000) into Psychometrics Toolbox STD V3.0 of Psychology Exploring System for calculation of total score and the score of each factor. The unanswered items in SCL-90 were labelled as "never", if more than 5 items were unanswered, the questionnaire was considered to be invalid and therefore rejected for analysis. The total score below 95 points in a questionnaire was considered to suggest low reliability of answers and the questionnaire was also rejected. All the data was input into computer and statistically analysed with SPSS 11.0 software. Differences among groups were compared by using t test.MAIN OUTCOME MEASURES: The scores of SCL-90.RESULTS: Totally 3 089 questionnaires were distributed and 2 994 of them were collected, with the effective rate of 96.92%, including 1 180male, 1 814 female, 2 847 freshmen of liberal arts and 1 147 freshmen of science. All the nine SCL-90 factor scores of the tested freshmen were significantly higher than those of Chinese youth's norm (P＜0.01). The female freshmen had significantly higher scores than the male freshmen in the factors of somatization, obsessive-compulsive, interpersonal sensitivity,depression, anxiety and phobia anxiety(P＜0.05-0.01 ), and contra in the factor of hostility(P＜0.01). There was no significant sex difference in the factor of paranoid ideation and psychoticism. The freshmen of liberal arts had significantly lower scores than the freshmen of science in the factors of obsessive-compulsive, hostility and psychoticism(P＜0.05-0.01 ), and contra in the factor of phobia anxiety(P＜0.05), there was no significant difference in the other factors between the two groups.CONCLUSION: The mental health level of freshmen of local normal university is lower than the average level of Chinese youth. The mental health status of the female freshmen is lower than that of the male freshmen. In obsessive-compulsive, hostility and psychoticism items,the freshmen of liberal arts and science are better than the freshmen of science, but in phobic anxiety items, it is contrary.

Objective To investigate the clinical features,treatment response and prognosis of patients with severe hemorrhagic fever with renal syndrome and complicated with acute anhemopoisis.Methods The clinical features of 18 patients with hemorrhagic fever with renal syndrome complicated with acute anhemopoisis were retrospectively analyzed.Resalts The clinical manifestations of the 18 adult patients(10 males and 8 females,age ranged from 14 to 55 years)with hemorrhagic fever with renal syndrome showed irregular fever,abrupt anemia and multiple sites hemorrhage at the severe stage(9-25 days after the onset).Peripheral leucocytes counts reduced to(2.3-3.2)×109/L,platelet to(23-31)×109/L,erythrocytes to(2.23-2.79)×1012/L,hemoglobulin to 52-67 g/L and reticulocyte to 0-0.002.Bone marrow test results showed that the hyperplasia of erythrocytes series decreased.The ratio of granulocyte to erythroeyte was significantly elevated,while granuloeyte and megalocaryocyte series decreased.The specific manifestations of acute anhemopoiesis were abrupt anemia,irregular fever and multiple sites hemorrhage.The major combined treatments were cortecosteroids and blood transfusion.These patients recovered at 26-60 days after the onset of the disease.Conclusions Hantaan virus could attack human bone marrow cells and induce cytopathogenic effect.In the course of hemorrhagic fever with renal syndrome,acute anhemopoisis could occur.The prognosis of these complicated cases is usually favorable.

Interactions between FMDV and cardiac cells are multifaceted and complex ,these interactions leads to pro-teins alterations in cardiac cells inevitably .To understand the pathogenesis of myocarditis after FMDV infection in mice ,the suckling mouse model for myocarditis induced by foot-and-mouth disease virus (FMDV) was established in this study .Suckling mice within 3 days old was selected to infect by FMDV .Myocarditis caused by FMDV in suckling mice was confirmed with clinical symptom monitor .The observation of Hematoxylin and eosin stain (H&E stain) and transmission electron microscopy (TEM) were performed after samples processing .According to conventional polymerase chain reaction (PCR) methods ,prim-ers of VP1 gene was designed ,synthesised and specific FMDV VP1 gene was amplified from the heart muscle of suckling mice . The results indicated that suckling mice appeared low spirit condition ,dyspnea ,and dull reaction within 36 hours after chal-lenge with FMDV .Infiltration of inflammatory cells and dissolution of myocardial fibers were observed with H&E stain and TEM .Special target gene of FMDV was amplified from the heart of infected group .Obvious inflammation in the heart of suck-ling mice caused by FMDV was observed .It's suggested that suckling mouse model for myocarditis induced by FMDV was es-tablished successfully ,which would lay the foundation for researches of myocarditis mechanism in young cloven-hoofed ani-mals .

Objective To analyse the effect of mobilization and collection's time of peripheral blood stem cells(PBSC) from 8 cases of healthy donors. Methods The 10 donors were studied by self-control design.The number of aphereses was two times every donors. Healthy donors received rhG-CSF according to two different PBSC collection starting time: group 1:PBSC collection was starts 2 hours(2 h) after the fourth day or the fifth day of rhG-CSF. group 2:PBSC collection was starts 4 hours(4 h) after the fourth day or the fifth day of rhG-CSF.(The first dose of rhG-CSF was given on day 1, considering day 0 as the day before starting mobilization). In this study we have compared with two groups of apheresis product. Results The MNC count was significantly higher for donors 4 h collection (groups 2) then 2 h. ( groups 1)(P

OBJECTIVE: To determine the value of high-resolution three dimensional contrast enhanced magnetic resonance venography (3D CE-MRV) in evaluating sinus meningiomas in the region of interest (ROI). METHODS: Twenty patients with sinus meningiomas underwent 3D CE-MRV with ROI preoperatively (including 9 patients postoperatively). We observed the changes of venous sinus adjacent the tumor. RESULTS: All patients received high-resolution image, the single acquisition time was about 11.4 s, and the voxel value was about 1.3 mm3. The images of 20 patients showed the change of the sinus clearly, 6 of which with integral sinus, 14 with sinus invaded at various degrees, including 5 with sinus occlusion and 9 with stenosis. CE-MRV also showed 4 patients with clear sinuses, 1 with narrow sinus, partial interruption, and 4 with sinus removed after the surgery. CONCLUSION Application of high-resolution 3D CE-MRV in ROI in sinus meningiomas may help obtain a series of high-resolution images in a short time, show the relationship between the tumor and venous sinus, display the degree of invasion of venous sinus clearly, provide information for the surgical treatment, and evaluate the change of sinus after the surgery.
Adult ; Aged ; Aged, 80 and over ; Cranial Sinuses ; pathology ; Female ; Humans ; Image Enhancement ; methods ; Imaging, Three-Dimensional ; Magnetic Resonance Angiography ; methods ; Male ; Meningeal Neoplasms ; diagnosis ; Meningioma ; diagnosis ; Middle Aged ; Phlebography ; methods

ObjectiveTo investigate the performance of fibrosis-4 （FIB-4） versus aspartate aminotransferase-to-platelet ratio index （APRI） in predicting advanced liver fibrosis and disease progression in patients with chronic HBV infection. MethodsA total of 497 patients with chronic HBV infection who underwent liver biopsy in The First Affiliated Hospital of Guangxi Medical University from February 2013 to December 2022 were enrolled， among whom 404 were enrolled in a retrospective study and 75 were enrolled in a prospective study. Related indicators were collected， including demographic features （sex and age）， biochemical indices （alanine aminotransferase ［ALT］ and aspartate aminotransferase ［AST］）， and platelet count， and FIB-4 and APRI were calculated. The Mann-Whitney U test was used for comparison of non-normally distributed continuous data between two groups， and the Kruskal-Wallis H test was used for comparison between multiple groups； the chi-square test was used for comparison of categorical data between groups. The area under the ROC curve （AUC） was used to assess the ability of APRI and FIB-4 in evaluating liver fibrosis degree and disease progression in patients with chronic HBV infection. ResultsIn the retrospective analysis， compared with the FIB-4<2.67 group， the FIB-4≥2.67 group had a significantly higher proportion of the patients who were diagnosed with liver cirrhosis or hepatocellular carcinoma （66.19% vs 47.54%， χ²=12.75， P<0.001）. The medians of FIB-4 and APRI increased significantly with liver fibrosis degree from F0 to F4 （H=42.5 and 35.9， both P<0.001）. As for the fibrosis stage of F0-F4， the median of FIB-4 was significantly higher than that of APRI in the patients with the same fibrosis stage （H=59.71， P<0.001）. FIB-4 and APRI had a similar AUC for predicting stage F3 fibrosis （0.67 vs 0.65， Z=0.71， P=0.480）， while FIB-4 had a higher AUC for predicting stage F4 fibrosis than APRI （0.72 vs 0.64， Z=10.50， P<0.001）. In the prospective study cohort， FIB-4 and APRI showed an increasing trend over time in predicting disease progression （chronic hepatitis B to liver cirrhosis）， with an AUC of 0.718 （95% confidence interval ［CI］： 0.476‍ ‍—‍ ‍0.760） and 0.555 （95%CI： 0.408‍ ‍—‍ ‍0.703）， respectively， and FIB-4 had a significantly higher accuracy than APRI in predicting disease progression （χ²=12.44， P<0.001）. ConclusionFIB-4 and APRI can be used to evaluate advanced liver fibrosis （F3 and F4） and predict disease progression， and FIB-4 is superior to APRI in certain aspects.

Objective: To evaluate the efficacy and safety of low dose sublingual nifedipine dripping pills (5 mg) in treating moderate and severe hypertension in comparison with normal dose (10 mg) of sublingual nifedipine dripping pills. Methods: This study was designed as a randomized, double-blind, positive drug parallel controlled, multi-center, non-inferiority clinical trial. Patients with moderate and severe hypertension were enrolled by 14 clinical trial centers, randomly divided into the trial group (sublingual 5 mg nifedipine dripping pills) and the control group (sublingual 10 mg nifedipine dripping pills). The changes in blood pressure were monitored continuously within 2 hours after the initial administration, repeated the dose in 20 minutes interval after the initial administration for up to additional 3 doses (maximum 4 doses) if the antihypertensive efficacy was not satisfactory. The efficacy of antihypertensive therapy between the two groups was evaluated by repeated administration rates and blood pressure changes at 60 minutes post the initial administration, and the safety of treatment was evaluated by recording adverse event rate of the two groups. Results: The anti-hypertensive effective rates at 60 minutes after sublingual administration were 83.5% (202/242) and 86.7% (208/240) respectively between the trial group and control group (χ²=1.307, P=0.253) . On the aspect of antihypertensive effectiveness at 60 minutes after single dose of sublingual administration, the anti-hypertension effective rates of the trial group and the control group were 85.6% (154/180) and 87.2% (164/188) respectively (χ²=0.221, P=0.639). Prevalence of the repeated administration was also similar between the two groups (25.6%(62/242) in the trial group and 21.7% (52/240) in the control group, χ²=1.043, P=0.307). On the safety aspect, there was no adverse events/reactions in the trial group, but there were 15 cases of adverse events/reactions occurred in control group (6.25%, χ²=15.611, P<0.001). Conclusions In the treatment of moderate to severe hypertension, the antihypertensive efficacy of low dose nifedipine dripping pills is similar to that of conventional dosage, and the safety profile of low dose nifedipine dripping pills is better than that of the conventional dose.