Objective To compare the efficacy and complications of Chinese Shang Ring circumcision with conventional circumcisiom Methods Clinical data of 479 cases of Chinese Shang Ring circumcision and 354 cases of conventional circumcision with complete follow-up were analyzed.Comparisons were made between the two groups on operation time,pain score,blood loss,postoperative complications,postoperative satisfaction with penile appearance,wound healing time and treatment costs. Results There was no statistical difference in age and foreskin status between the two groups (P＞0.05).For the Shang Ring group,the operation time was(5±1)rain,blood loss was (0.98±1.14)ml,pain score during operation was 0.25±0.54,24-hour pain score after operation was 1.63±0.87,the postoperative complication rate was 6.89% (33/479),wound healing time was (20±5)d,the satisfaction rate of appearance was 99.79% (478/479),and treatment cost was (871±52) yuan.For the conventional group,the operation time was (27±5) min,blood loss was (8.30±3.60)ml,pain score during operation was 3.29±1.57,24-hour pain score after operation was 5.56±1.42,the postoperative complication rate was 13.28%(47/354),wound healing time was (13±2)d,satisfaction rate of appearance was 92.37% (327/354),and treatment cost was (554±46) yuan.Compared with the conventional group,the Shang Ring group had a shorter operation time,less blood loss,less pain score,higher appearance satisfaction rate and a lower complication rate (P＜0.05).But wound healing time was longer and treatment cost was higher in the Shang Ring group (P＜0.05). Conclusions Chinese Shang Ring circumcision is simpler and an improved approach over conventional circumeision with shorter operative time,less blood loss,less pain,relatively lower complication rate and higher satisfaction and acceptability.

The main reason of invalidation of prosthetic hip joint is the prostheses flexibility and shift, dislocation and disjunction. Promoting the long time stability of the prostheses is the key of improving the long term hip joint replacement effect. Former research work was focused on the upper segment of femur, and assumed the acetabulum cup to be a spheric concave, and the external form of acetabulum prostheses was basically semi spheric. This paper presents a method of acquiring the point data on the surface of the hip bone using the reverse engineering technology. By analyzing the acetabulum surface fitting error we use rotating elliptical surface to fit the acetabulum surface, together with the optimal technique to build up the CAD model of acetabulum surface. We compare the fitting error between the sphere fitting and rotating elliptical surface fitting and get the result that the rotating elliptical surface fitting error is smaller than the sphere fitting error, and the rotating elliptical surface can describe the shape of the acetabulum better.
Acetabulum ; anatomy & histology ; Anthropometry ; Arthroplasty, Replacement, Hip ; Computer Simulation ; Computer-Aided Design ; Hip Joint ; anatomy & histology ; Hip Prosthesis ; Humans ; Models, Anatomic ; Prosthesis Design

By using the reverse engineering (RE) technology, the mesh surface model of acetabulum was reconstructed by triangulation. Based on this kind of model, the local morphological analysis (LMA) and global morphological analysis (GMA) could be processed. The fitting minimal quadric surface method was applied to calculate the curvature of any point on the acetabulum bony surface, the local morphological character of its surface could be acquired, and its global surface character could be determined by GMA. The results showed that the acetabulum bony surface is elliptical surface, and its three eigenvalues (lambda1, lambda2, lambda3) relations on the three axes (x, y, z) are as follows: lambda1 is short than lambda2 and lambda3, lambda2 is close to lambda3.
Acetabulum ; anatomy & histology ; Humans ; Models, Anatomic

The research on the morphology features of the acetabulum bone joint surface area would be helpful to establishing the acetabulum 3D model for the purpose of the biomechanical analysis of hip joint, and therefore might have its important clinical significance. However, in former studies, the acetabulum was simply considered as a semi sphere. In this study, based on the acetabulum 3D-point data acquired by the 3D laser surface scanner and the reverse engineering technology together with the optimal fit algorithm, two kinds of best-fit model were achieved by a sphere surface and a rotating elliptical surface respectively approaching to the acetabulum bone joint surface. Both fitting errors were then compared and analyzed. The results showed that the fitting error of the rotating elliptical surface was significantly less than that of the sphere surface (P < 0.001). The average radius of fitting sphere was 24.37 +/- 2.22 mm and the average long axis of fitting rotating elliptical surface was 26.02 +/- 2.76 mm while its short axis was 24.17 +/- 2.16 mm. These findings would be helpful to our new recognition of the acetabulum since they were results of the first quantitative analyses for the acetabulum bone surface and also might serve as an important reference base in its further studies and application.
Acetabulum ; anatomy & histology ; Adult ; Algorithms ; Humans ; Imaging, Three-Dimensional ; Models, Anatomic

Objective:To evaluate the effects of individual extralevator abdominoperineal excision (ELAPE) of rectal neoplasms in the low posterior wall on the pelvic floor by finite element analysis. Methods:MIMICS 10.01, Geo Magic Studio 12, and ANSYS Workbench 14.0 were used to analyze the magnetic resonance data obtained from the pelvic region of 27 healthy nulliparous volunteers. Three types of finite element models (intact model, ELAPE model, and individual ELAPE model) were developed. The maximal stress on non levator ani tissues were analyzed using the three models, while the maximal stress on levator ani tissues were analyzed using the in-tact model and the individual ELAPE model. Their stress distributions under the same pressure were analyzed and compared. Results:The maximal stress on non levator ani tissues obtained using the intact model, ELAPE model, and individual ELAPE model were (1.963± 0.061), (5.127 ± 0.070), and (3.667 ± 0.126) MPa, respectively, with P<0.01. High-stress zones were obtained at the joints with pelvic walls on both sides using the three models, while the maximal stresses were obtained at the joints with pubis on both sides. The maxi-mal stress on levator ani tissues obtained using the intact model and individual ELAPE model were (0.812 ± 0.042) MPa and (1.437 ± 0.043) MPa, respectively. Thus, the individual ELAPE model yielded higher values of maximal stress compared to the intact model. Both models generated high-stress zones at the joints with tendinous arch of levator ani tissues on both sides, and maximum stresses at the joints with pubis on both sides. Conclusion:Individual ELAPE decreases the stress on non levator ani tissues. This suggests that the risk of postoperative pelvic floor hernia is relatively reduced.

Objective To study the current situation of fast-track surgery nursing in the department of urology,in order to provide theory basis for nursing clinical research and practice in the development of urology in the future.Methods The data were collected from American PubMed database,domestic Wanfang database and CNKI from May to August 2016. The bibliometric analysis was used to analyze all collected research literatures about fast-track surgery nursing in the department of urology according to country,year,disease classification,publication and so on.Results From January 1st,1995 to August 17th,2016,a total of 96 research articles about fast-track surgery nursing in the department of urology were collected from the databases of PubMed,Wanfang and CNKI. There were 73 Chinese articles,accounting for 76.04%. The research themes were kidney disease (41.67%),bladder disease (35.42%) and prostate disease (14.58%). The postoperative fast-track surgery of urinary system tumor accounted for 65% in the domestic and foreign research.Conclusions The fast-track surgery of kidney and bladder diseases is the hotspot of study. The renal tumor radical operation and the urinary bladder carcinoma radical operation with urinary diversion are hot research directions of fast-track surgery. Randomized control method used in clinical patients is the main research method for the application of fast-track surgery concept.

Objective To investigate the impact of spermidine on proliferation and apoptosis of diffuse large B-cell lymphoma(DLBCL)cell lines.Methods The impact of spermidine on cellular growth was assessed using a CCK-8 assay.Flow cytometry was employed to investigate the effects of spermidine on the proliferation and cell cycle dynamics of DLBCL cell lines,as well as to evaluate its influence on apoptosis in DLBCL cell lines,mouse splenocytes,and peripheral blood mononuclear cells(PBMCs)derived from healthy individuals.Western blot analysis was conducted to examine alterations in protein expression levels associated with apoptosis and the cell cycle following treatment with spermidine.Results The CCK-8 assay revealed a significant inhibitory effect of spermidine on DLBCL cell growth(P<0.001).Flow cytometric analysis demonstrated that spermidine had no impact on the proliferation or cell cycle of DLBCL cells,but significantly induced apoptosis(P<0.001).Spermidine exhibited a pro-apoptotic effect on mouse splenocytes(P<0.01),albeit weaker compared to its effect on DLBCL cells(P<0.001),and showed no significant pro-apoptotic effect on PBMCs.Western blot results indicated that spermidine did not influence the expression levels of cell cycle proteins CDK2 and CDK4,but enhanced the activation of Caspase-9 in A20 cells and Caspase-8 in OCI-Ly3 cells.Conclusion Spermidine induces apoptosis and suppresses cell growth in DLBCL cell lines,while exhibiting diminished or absent pro-apoptotic effects on mouse splenocytes and healthy human PBMCs,suggesting its potential as a specific inhibitor for the growth of DLBCL cell lines in vivo.

OBJECTIVE To study the effects of disodium cantharidinate on the pharmacokinetic behavior of capecitabine in rats. METHODS Rats were randomly divided into two control groups and two experimental groups with 6 rats in each group. Two control groups were intraperitoneally injected with normal saline， and two experimental groups were intraperitoneally injected with Disodium cantharidinate injection of 0.5 mL/kg， for 7 consecutive days. Eight days after medication， control group 1 and experimental group 1 were given capecitabine 5 mg/kg intragastrically， while control group 2 and experimental group 2 were given capecitabine 5 mg/kg intravenously. Blood samples were collected at different time points after administration. After extraction with ethyl acetate， the concentration of capecitabine in rat plasma was determined by UPLC-MS/MS method using tolbutamide as the internal standard. The pharmacokinetic parameters were calculated by DAS 2.0 software. RESULTS Compared with control group 1， MRT0－∞， cmax， AUC0－30 h， AUC0－∞ and F of experimental group 1 were increased significantly， while CLz/F was decreased significantly （P＜0.01）. Compared with control group 2， t1/2， MRT0－30 h， MRT0-∞， AUC0－30 h and AUC0－∞ of experimental group 2 were increased significantly （P＜0.01）. CONCLUSIONS Disodium cantharidinate can increase the plasma exposure of capecitabine in rats， improve its oral bioavailability， prolong the average residence time， and reduce its clearance rate.