No abstract available.
Actins ; Keratosis, Actinic ; Prevalence

No abstract available.
Actins* ; Humans ; Keratosis, Actinic* ; Phototherapy*

Circumscribed palmar or plantar hypokeratosis is a rare condition characterized by the occurrence of an erythematous, well-circumscribed, and depressed macule or patch on the palms or soles. Histopathologically, it is characterized by sharp, stair-like abrupt thinning of the horny layer between the affected and unaffected skin. The pathogenesis of this condition remains unclear. Recently, the human papilloma virus has been implicated as a possible etiological contributor. Circumscribed palmar or plantar hypokeratosis usually shows a benign course. Previous reports have not described malignant changes in these lesions. However, its association with actinic keratosis has been reported in a previous case. We report a case of circumscribed palmar hypokeratosis showing bowenoid epidermal change with expression of the human papilloma virus types 6 and 16 in a patient who was successfully treated with ingenol mebutate gel and cryotherapy.
Cryotherapy ; Humans* ; Keratosis, Actinic ; Papillomaviridae* ; Skin

Transfollicular extrusion of sebaceous gland lobules was observed in a case of actinic keratosis and 2 cases of sebaceous hyperplasia. The patient of act.inic keratosis was a 44-year-old white man and the patients of sebaceous hvperplasia were a i3-year-old Korean girl and a 28-year-old Korean man. The sebaceous gland lobules located within the dilated infundibular area and partly between separated granular layers were intact and partly surrounded by keratin materjal. No histopathologic overlapping of sebaceous gland lobules was observed. We suppose that transfollicular ext,rusion of sebaceous gland lobules may not be artifact. but one of natural phenomena. But further study will be necessary to evaluate the significance of this peculiar histopathologic findings.
Adult ; Artifacts ; Female ; Humans ; Hyperplasia ; Keratosis ; Keratosis, Actinic ; Sebaceous Glands*

BACKGROUND: Photodynamic therapy(PDT) is a type of photochemotherapy that is designed to kill targeted tumor cells. OBJECTIVE: The Clinical effects of PDT were analysed for response rates, post-treatment healing and adverse effects on several cutaneous carcinoma in situ. METHOD: PDT with topical 5-aminolevulinic acid-based irradiation of corresponding 630+5nm light was performed in 6 carcinoma in situ patients who had actinic keratosis, Bowen' disease or cutaneous squamous cell carcinoma. RESULT: In all patients the clinical results were exellent with respect to initial complete responses and cosmetic outcome. CONCLUSION: PDT might be chosen as a first line treament for cutaneous carcimoma in situ.
Carcinoma in Situ* ; Carcinoma, Squamous Cell ; Humans ; Keratosis, Actinic ; Photochemotherapy* ; Skin*

No abstract available.
Carcinoma, Squamous Cell* ; Keratosis, Actinic* ; RNA-Binding Proteins* ; Skin*

The chemical peeling is the process that involves the application of one or more exfoliating agents to the skin, resulting in the destruction of portions of the epidermis and/or dermis with subsequent regeneration. These techniques produce a controlled wound with instant vascular coagulation resulting in skin rejuvenenation with reduction or disappearance of actinic keratoses and changes, pigmentary dyschromias, rhytides, and selected superficial depressed scar. We herein introduce brief skin resurfacing techniques, indications, effectiveness, side effects of chemical peeling, dermabrasion, laser resurfacing.
Cicatrix ; Dermabrasion ; Dermis ; Epidermis ; Keratosis, Actinic ; Regeneration ; Skin ; Wounds and Injuries

No abstract available.
Carcinoma, Basal Cell* ; Cicatrix* ; Keratosis, Actinic* ; Laser Therapy*

BACKGROUND: In accordance with the increase of the old age group, the incidence of actinic keratosis (AK) also increases. But there has been no comparative study between the clinical and histopathological margins. OBJECTIVE: The purpose of this study was to compare the clinical margin with histopathological margin of AK in Korean patients. METHOD: All cases of AK confirmed by biopsy from February 1, 1993 to May 31, 2003 were reviewed by hospital records and biopsy slides. Total 50 AK cases excised with 2mm surgical free margin were selected and analyzed clinically and histopathologically. RESULTS: 1. Histopathologically, hypertrophic type of AK was noted in 18 cases (36%), atrophic type in 8 cases (16%), bowenoid type in 5 cases (10%), acantholytic type in 3 cases (6%), pigmented type in 2 cases (4%), and combined form of hypertrophic and atrophic types was noted in 7 cases (14%), combined form of atrophic and pigmented types in 5 cases (10%), and combined form of acantholytic and pigmented types in 2 cases (4%). 2. The total proportion of surgical margin involvement was 44% (22/50): hypertrophic type in 55.5% (10/18), atrophic type in 87.5% (7/8), bowenoid type in 20% (1/5), acantholytic type in 33.3% (1/3), pigmented type in 0% (0/2), combined form of hypertrophic and atrophic types in 28.5% (2/7), combined form of atrophic and pigmented types in 20% (1/5), and combined form of acantholytic and pigmented types in 0% (0/2). CONCLUSION: In 50 cases of AK excised with 2mm surgical free margin, 22 cases (44%) showed tumor cells on the surgical margin. Especially hypertrophic and atrophic types showed significant proportion of marginal involvement. In respect that hypertrophic and atrophic types are more common than other subtypes of AK in Korean patients, skin biopsy and check-up for surgical margin are recommended in all AK.
Actins* ; Biopsy ; Hospital Records ; Humans ; Incidence ; Keratosis, Actinic* ; Skin

We examined the amyloid deposit in various malignant cutaneous epithelial tumors by using Dylon stain. Histochemically identifiable amyloid deposits associated with basal cell epitheliomas(BCEs), squamous cell carcinomas(SCCs) and Bowens diseases were studied with monoclonal cytokeratin antibodies and anti-amyloid P antibodies. The results were as follaws, l. Amyloid deposits were detected in 5 of 12 BCEs, 4 of 11 SCCs, 3 of 9 Bowens diseases and 1 of 8 actinic keratoses. Amyloid deposits were not detected in o keratoacanthomas, 2 verrucous carcinomas, 1. Pagets disease and 3 extramammary Pagets diseases. 2. Anti-keratin antibody 34BE12 and anti-amyloid P antibody reacted with amyloid deposits in 3 of 5 BCEs which showed abundant amyloid deposits by Dylon stain. 3. Of 4 SCCs which showed amyloid deposits by Dylon stain, anti-keratin ant.ibody 34pE12 reacted with amyloid deposits in 2 cases and anti-amyloid P antibody reacted with amyloid deposits in 3 cases. 4. Anti-amyloid P antibody reacted with arnyloid deposits in 3 of 3 Bowens diseases which showed arnyloid deposits by Dylon stain. Anti-keratin antibody 34pE12 reacted with amyloid deposits only 1 of them. These findings suggest that epidermal keratins are the percursor substance of amyloid in malignant cutaneous epithelial tumors. The difference of antikeratin staining pattern between BCE-associated amyloid and SCC or Bowens disease-associated amyloid may be the results of difference in development stage of cutaneous amyloids.
Amyloid* ; Antibodies ; Carcinoma, Verrucous ; Keratins ; Keratoacanthoma ; Keratosis, Actinic ; Plaque, Amyloid*