Author experienced 10 cases of keratitis which have been relatively good improved by subconjunctival injection of Tathion(50mg.), a glutathion preparation without any special complication. Previous case report for 5 cases of keratitis treated with Tathion was published by Rhee and Kim. (1972, June.)
Keratitis*

No abstract available.
Keratitis*

No abstract available.
Keratitis

No abstract available.
Keratitis* ; Korea*

Introduction: A hospital based case control study was conducted in government hospitals on contact lens patients diagnosed with microbial keratitis. Methods: The objective of this study is to determine the visual outcomes of contact lens related microbial keratitis. The visual outcomes which comprised of visual acuity, keratometry readings, corneal topography findings and contrast sensitivity examinations was determined after three months from the first presentation at the hospitals. Results: The mean LogMAR visual acuity during presentation was 0.96 ± 0.73 or a Snellen equivalent 6/60 (n=76) and mean LogMAR visual acuity after three months was 0.10 ± 0.48 or a Snellen equivalent 6/7.5 (n=76) with a significant difference (t=11.22, df=78, p=0.001). Best fit curve for the cases had a regression coefficient, r=0.350 ± 0.063 (95% CI = 0.224, 0.447, df=78, p=0.001. The visual acuity in cases and controls was 0.10 ± 0.48 and -0.10 ± 0.14 respectively (t= -3.61, df=154 p=0.001) after three months which showed improvement. There was a reduction in the corneal uniformity index and corneal asphericity in the cases. The Corneal Uniformity Index (CU index) in cases was 63.03 ± 26.38 (n=76) and in controls, 80.13 ± 11.30 (n=77), (t= -5.22, df=151, p=0.001). There was also a reduction in the contrast sensitivity function at all spatial frequencies in the cases which was significantly different. Conclusion: Microbial keratitis reduced the vision, corneal uniformity index, asphericity and contrast sensitivity after three months in eyes of patients diagnosed with the condition.
Keratitis ; Eye

Acyclovir is highly selective and relatively non-toxic anti-herpes agent. Thirt-y-seven patients with herpetic keratitis were treated with acyclovir. (23 patients with pure epithelial type, 4 patients with accompanying stromal keratitis, and 10 patients with accompanying keratouveitis). Acyclovir was very effective in 23 patients with pure epithelial herpetic keratitis. All epithelial defects healed in a mean healing time of 6.2 +/- 2.3 days. In 4 patients with stromal keratitis, 3 patients healed within 14 days and 1 patient healed on 27 days. In 10 patients with keratouveitis, 8 patients healed within 14 days, 1 patient healed on 21 days, and 1 patient was not healed even after one month. Four patients developed superficial punctate keratopathy during therapy, but no other serious adverse effects were seen.
Acyclovir* ; Humans ; Keratitis ; Keratitis, Herpetic*

Acyclovir is highly selective and relatively non-toxic anti-herpes agent. Thirt-y-seven patients with herpetic keratitis were treated with acyclovir. (23 patients with pure epithelial type, 4 patients with accompanying stromal keratitis, and 10 patients with accompanying keratouveitis). Acyclovir was very effective in 23 patients with pure epithelial herpetic keratitis. All epithelial defects healed in a mean healing time of 6.2 +/- 2.3 days. In 4 patients with stromal keratitis, 3 patients healed within 14 days and 1 patient healed on 27 days. In 10 patients with keratouveitis, 8 patients healed within 14 days, 1 patient healed on 21 days, and 1 patient was not healed even after one month. Four patients developed superficial punctate keratopathy during therapy, but no other serious adverse effects were seen.
Acyclovir* ; Humans ; Keratitis ; Keratitis, Herpetic*

This study was performed to observe the sequential charge of the morpholcgic characteristics in experimentally induced herpes simplex keratitis. Duration and morphology of corneal lesion following infection of rabbit cornea with the Kos strain of HSV-I were followed by a daily slit-lamp examination. Three types of virus inoculation methods were used such as scratching, deepithelialization, and intrastromal injection. Herpetic corneal lesions appeared 24 hours after inoculation with punctate and dendritic figures. They persisted up to 14 or 15 days. The characteristic finding in punctate herpetic keratitis was grouped, round-shaped, punctate lesion. When scratching method was emplyed, the most remarkable finding was the discontinuity of the lesion occurred along the scratching wound at relatively regular intervals. There was no difference in lesional morphology and duration between three inoculation methods.
Cornea ; Keratitis* ; Keratitis, Herpetic ; Wounds and Injuries

PURPOSE: To compare the corneal first surface higher-order aberrations (HOAs) of normal subjects and patients with dry eye using KR-1W(R) (Topcon Corp., Tokyo, Japan) and Pentacam(R) HR (Oculus Inc., Dutenhofen, Germany). We analyzed the relationship between the aberrations and the diagnostic parameters of dry eye. METHODS: We evaluated anterior corneal HOAs in 71 normal eyes and 71 dry eyes using KR-1W(R) and Pentacam(R). Dry eye patients were examined for fluorescein staining, tear break-up time (TBUT), and Schirmer I test. Ocular Surface Disease Index (OSDI) was used for assessment of subjective symptoms in dry eye patients. RESULTS: HOAs measured by both instruments were greater in the dry eye group than in the control group, although HOAs using KR-1W(R) only achieved statistical significance. The anterior corneal HOAs measured by the 2 instruments were significantly correlated with superficial punctate keratitis. Moreover, TBUT and the Shirmer I test negatively correlated, and OSDI positively correlated, with anterior corneal HOAs. CONCLUSIONS: The HOAs in patients with dry eye were significantly different from controls and tended to increase with disease severity. KR-1W(R) might be more useful than Pentacam(R) to detect tear film instabilities.
Fluorescein ; Humans ; Keratitis ; Tears

Authors experienced five different cases of keratitis such as metaherpetic keratitis, bullous keratitis, chemical keratitis and superficial punctate keratitis have been markedly improved by subconjunctival injection of Tathion (30-50mg), a glutathion prepartion. All cases showed remarkable improvement with better visual acuity following the treatment. Especially it was another choice of treatment in persisting case of metaherpetic keratitis with parenchymal infiltration. No side effects have been observed during this procedure.
Keratitis* ; Visual Acuity