Objective:To investigate the sleep quality of the people aged over 18-years-old in Hebei province and the impact of relative factors on it.Methods:Sum total of 20 716 random samples at ages over 18 were selected among the general population.The tools were Pittsburgh Sleep Quality Index(PSQI),Simplified Coping style Questionnaire(SCSQ).Results:The total prevalence of low sleep quality was 11.6 %(2411/20716).Female had higher standardized prevalence rate than male(6.8% vs.4.8%).Logistic analysis showed that risk factors to low sleep quality were ages over 70-years-old,remarriage,divorce,bereft,negative coping style(OR=1.776,1.515,2.046,1.254,1.097).On the other hand,factors to good sleep were the Han nationality,male,farmer,the family average annual income ranged 5001-10000 RMB,10001-20000 RMB,20001-40000 RMB,positive coping style(OR=0.839,0.703,0.732,0.750,0.660,0.573,0.936).Conclusion:Low sleep quality had high prevalence in Hebei.It should be recognized by medical workers.

Objective To research in death reason and corresponding nursing measures to provide evidence for clinical nursing and medical service through analysis of death data of mental disorder inpa-tients. Methods Data of 128 mental disorder inpatients died in hospital were reviewed and analyzed.Results Among death reasons of these patients:physical disease (50.8%)was the most common death rea-son,followed by accidents (19.5%) and sudden death (19.5%).Death happened on first admission was 91 cases (71.1%).Death happened within 10 days of hospitalization was 60 cases (46.9%).The occurrence of death was common on nighttime, after lunch and meals time. Conclusions Physical disease,accidents and sudden death were main death reasons of mental disorder inpatients.Medical workers should pay atten-tion to patients who were on first admission or within 10 days of hospitalization and strengthen nursing work on special time.

Objective: To investigate the status and influencing factors of substance-induced psychotic disorders in residents over 18 years old in Hebei Province, and to provide evidence for the prevention and control of substance-induced psychotic disorders. Methods: Using multi-stage stratified random sampling method, the permanent residents aged 18 years and over were selected from urban and rural areas in Hebei Province. The demographic data was collected, the 12-Item General Health Questionnaire ( GHQ-12 ) and eight risk factors about mental disorder questionnaire were used to find out mental disorders. The multivariate logistic regression model was conducted to analyze the influencing factor for substance-induced psychotic disorders. Results: A total of 23 675 questionnaires were sent out, 20 884 were valid ( 88.20% ).The weighted lifetime prevalence rates of substance-induced psychotic disorders, alcohol-related disorders, sedatives/hypnotics/anti-anxiety disorders and other substance-induced psychotic disorders were 6.20%, 5.93%, 0.24% and 0.04%, respectively. Multivariate logistic regression analysis showed that age ( 35-<45, OR=1.582, 95%CI: 1.091-2.292; 45-<60, OR=2.185, 95%CI: 1.524-3.132; ≥60, OR=2.061, 95%CI: 1.422-2.986 ), males ( OR=10.832, 95%CI: 8.265-14.196 ), urban area (OR=1.431, 95%CI: 1.202-1.703 ), non-poor family ( OR=2.291, 95%CI: 1.652-3.177 ), physical diseases ( OR=2.028, 95%CI: 1.678-2.452 ) and genetic history ( OR=1.574, 95%CI:1.181-2.098 ) were the influencing factors for substance-induced psychotic disorders. Conclusion The lifetime prevalence of substance-induced psychotic disorders among residents aged 18 years and over in Hebei Province is 6.20%, which is mainly related to age, gender, region, family economic situation, physical disease history and genetic history.

BACKGROUND: By detecting vasoactive substances of experimental rats with myocardial ischemia, pharmacological mechanism of xiongbitong was studied in this research.OBJECTIVE: To observe the effect of xiongbitong capsule on release of vasoactive substances of rats with myocardial ischemia.DESIGN: A completely randomized controlled study.SETTING: Department of Health, Weifang Medical College; Department of Physiology, Department of Immunity and Pathogenic Biology, Department of Internal Medicine, Weifang College of Traditional Chinese Medicine.MATERIALS: The experiment had been carried out in the Laboratory of Physiology of Weifang Medical College from January 2003 to June 2003.The cleansing grade 30 Wistar rats, 6-8 months, of either sex, were randomly divided into three groups:namely, normal control group, model control group and model group of treatment with xiongbitong capsule.METHODS: [1] At 12 hours before making model, rats of model treatment group were irrigated with xiongbitong capsule 2.5 g/kg (a capsule contents dried medicinal herbs 1 g), which consists of tuckahoe, rhizoma, immature bitter orange, exocarpium citri grandis, rhizoma acori tatarinowi, moxibustion, dalbergia wood, mongolian snakegourd, curcuma root, red sage root,root of donopsis pilosula, ilyturf root, ophiopogon, polygala root, date kernel etc., and dissolved in 4 mL physiological saline. AT ten hours after making model, they were irrigated with same dose once more. The rats of normal control group and model control group were irrigated with the same dose physiological saline at the same time. One hour after the first irrigation, the animal models of myocardial ischemia of rats of model control group and model treatment group were established by injecting vitriol isoprenaline according to 10 mg/kg subcutaneously. [2] Endothelin (ET), calcitonin generelates peptide (CGRP), 6-keto-prostaglandin Fl alpha (6-keto-PGF1α) and thromboxane B2 (TXB2) in the plasma of rats were detected according to the explanation of Institute of Beijing East Asia Immune Technique. [3] The analysis of variance and q test were used for comparing between groups.MAIN OUTCOME MEASURES: Contents of vasoactive substances in the plasma of rats in each experimental group.RESULTS: The date of all thirty rats was entered the final analysis. [1]The contents of (TXB2) and ET, TXB2/6-Keto-PGF1α, ET/CGRP: Compared with the model group, the normal control group and model treatment group reduced obviously (q=2.99-9.87, P ＜ 0.05-0.01). [2] The contents of 6-Ke-to-PGF1α and CGRP: Compared with the model group, the normal control group and model treatment group increased obviously [(603.3 ±90.6),(190.0±64.2) ng/L; (560.7±111.1), (174.9±41.4) ng/L; (380.4±705),(114.9±36.4) ng/L, q=3.88-7.64, P ＜ 0.05-0.01].CONCLUSION: Xiongbitong capsule may suppress unusual release of vasoactive material at myocardial ischemia area obviously, increase the content of expanding the blood vessel material, and correct out-of-balance of content of important TXB2, 6-keto-PGF1α, XTB and CGRP in the body.

Objective To explore the features of the parental rearing behavior in schizophrenics with a brilliant school records.Methods 51 schizophrenics in remission with brilliant records were tested by EMBU.36 healthy volunteers were randomized into the controls group.Result Subjects with schizophrenia had abnormal parental rearing behavior,such as overprotection, predilection over intervention and over punishment of parents.Most of them come from peasant family.Conclusion The factors such as abnormal parental rearing behavior probably influence the development of schizophrenics.

Background and purpose: AMP-activated protein kinase (AMPK) plays an important role in the regulation of cell metabolism and energy balance and is associated with cell proliferation, survival and multiple signaling pathways. Recent reports found that AMPK is involved in tumor suppression and drug resistance. The aim of this study was to explore the effect of AMPK on the anti-tumor effect of adriamycin and underlying mechanism in breast cancer MCF-7/adr cells. Methods:The anti-proliferative effects of adriamycin was detected by methyl thiazolyl tetrazolium (MTT) assay in MCF-7/adr, MCF-7/adr-vector and MCF-7/adr-AMPKαcells. The cell morphology in each group was stained with the lfuorescent dye Hoechst 33528, and the effects on apoptosis induction were examined by lfow cytometry (FCM). The intracellular concentration of adriamycin was detected by lfuorescence assay. The resis-tance-and apoptosis-related proteins were analyzed by Western blot. Results:The growth of breast cancer MCF-7/adr cells was inhibited by adriamycin in a dose-and time-dependent manner. The IC50 values at 24 and 48 h were (36.8±2.1) and (28.8±1.3) μg/mL, respectively. AMPKαover-expression enhanced the cytotoxic effect of adriamycin in MCF-7/adr-AMPKαcells in a dose-and time-dependent manner. Its IC50 values at 24 and 48 h were (16.0±0.7) and (4.2±0.2) μg/mL, respectively. Fluorescent morphological assay showed that AMPKαoverexpression contributed to adriamycin induced apoptosis in MCF-7/adr-AMPKαcells. After treatment with 1.0 μg/mL adriamycin for 48 h, the apoptosis rates of MCF-7/adr, MCF-7/adr-vector and MCF-7/adr-AMPKα cells were (12.0±1.4)%, (12.7±1.6)% and (32.0±4.2)%, respectively, indicating that overexpression of AMPKα enhanced the adriamycin-induced apoptosis in MCF-7/adr cells. Fluorescence microplate assay showed that over expression of AMPKαsigniifcantly increased the intracellular accumulation of adriamycin, in a concentration dependent manner. Western blot analysis showed that, compared with MCF-7/adr and MCF-7/adr-vector cells, the expressions of Bax, caspase-3 and cleaved PARP proteins were increased. Meanwhile, Bcl-2 and P-gp protein expressions were decreased in MCF-7/adr-AMPKαcells. Furthermore, the release of cytochrome c from mitochondria into the cytosol was also observed in MCF-7/adr-AMPKαcells. Conclusion:AMP-Kαoverexpression can enhance the chemosensitivity of breast cancer MCF-7/adr cells to adriamycin through inhibiting the drug effux transporter and regulating the expression of apoptosis-related proteins.

OBJECTIVE:To provide reference for rational use of antipsychotic drugs in schizophrenia patients. METHODS:The general information and antipsychotic treatment information,which were extracted from the database of prior drug investigation in Mental Health Center of Hebei Province in 2002,2006 and investigation data in 2012 of 5014 schizophrenia patients,were ana-lyzed. RESULTS:Over time,the frequency of the first generation antipsychotic drugs decreased(P<0.05),while that of the sec-ond generation antipsychotic drugs increased (P<0.01). The frequency of long-acting antipsychotic drugs were generally low among outpatients and inpatients in 2002,2006,2012,with statistical significance(P<0.01). There were no significant difference in the proportion of outpatients receiving antipsychotic drugs combination treatment and monotherapy (P>0.05). Over time,the proportion of inpatients receiving monotherapy decreased,while that of inpatients receiving combination treatment increased (χ2=18.682,P<0.01). CONCLUSIONS:The second generation antipsychotic drugs have gradually replaced the first generation antipsy-chotic drugs,and have became the leading drugs in the treatment of schizophrenia in Hebei province. The proportion of inpatients receiving combination treatment has increased,which is different from the domestic and foreign prevention and treatment guide-lines.

Objective To compare the differences of prescription pattern, adverse events, economic burden and drug-use adherence between preferred mood stabilizers and preferred antipsychotics in patients with bipolar disorder. Methods We investigated 240 cases of patients with bipolar disorder from 39 mental health institutions in 11 cities in Hebei province. The self-made questionnaire was used to investigate the demographic information, disease characteris-tics, prescription pattern and medical expense. The clinical global impression scale-severity of illness (CGI-SI) was used to assess the disease severity. The treatment emergent symptom scale (TESS) was used to assess the adverse drug reac-tions. The medication adherence rating scale (MARS) was used to assess drug therapy compliance in patients. Results One hundred fifty-two patients (63.3%) used antipsychotics as the first choice (antipsychotics group), 88 patients (36.7%) used mood stabilizers as the first choice (mood stabilizers group). The number of patients in-patient (90.1%vs. 76.1%), patients with psychotic symptom (27.0%vs. 11.4%), incidences of adverse events (46.1%vs. 31.8%), drug daily cost (me-dians 12.00 yuan vs. 8.37 yuan) and drug total cost (medians 344.61 yuan vs. 144.64 yuan) were larger in antipsychotics group than in mood stabilizers group (P<0.05). There was no significant difference between two groups in pattern of pre-scription, severity of adverse events and total scores of MARS (P>0.05). Conclusion The bipolar disorder patients more frequently use antipsychotics as the first choice in Hebei province. The use of antipsychotics does not alter the combina-tion medication pattern. In addition, antipsychotics cause a higher incidence of adverse events and heavier economic bur-den compared with mood stabilizers, suggesting that mood stabilizers should be the first choice to bipolar disorder.

Through the addition of discussion course associated with judicial expertise during the pre medical education, integration of true and typical forensic pathological cases into basic medical theory and experimental education, further addition of optional course of forensic medicine,and guiding the medical students applying the scientifically training projects about forensic pathology, students may improve their learning interesting and clinical thought, and are made early warning and increase the abilities of preventing and dealing with the suddenly medical tangles in the future, at the same time, the medical teachers also increase their professional levels and teaching qualities.These benefit the growing up of high quality medical doctors, decrease and even prevent the happening of medical tangles.

Objective To compare the efficacy and safety of tamsulosin with nifedipine for medical expulsive therapy (MET) in patients with lower ureteral stones (LUS).Methods Randomized controlled trials(RCTs) in comparison of tamsulosin and nifedipine in treatment of LUS published in Pubmed, Cochrane Library,Embase,CNKI,CBM, Wanfang and VIP from databases establishment to July 2015 were retrieved.According to Cochrane handbook, the quality of included RCTs were assessed, and the relevant data including the number of participants, stone size, stone expulsion rate, time to stone expulsion, drug-related side effect,the incidence of ESWL or ureteroscopy lithotripsy (URSL) after MET and analgesic dose were extracted by two reviewers independently.The statistical software RevMan 5.2 was used for meta-analysis with regard to the stone expulsion rate, the incidence of ESWL or URSL and adverse effects.This study lasted more than one month from June to July 2015.Results A total of 13 RCTs with 4 831 patients were eligible.The results showed that the stone expulsion rate and the incidence rate of ESWL or URSL after MET were 92％ (2 221/2 423) and 8％ (27/333) in the tamsulosin group,and 73％ (1 748/2 408) and 20％ (67/328) in the nifedipine group.There are statistically significant differences (RR =1.24,95 ％ CI 1.13-1.37, P ＜ 0.05;RR =0.40,95 ％ CI 0.27-0.60, P ＜ 0.05, respectively).The subgroup analysis indicated no statistically significant differences in drug-related adverse effects between tamsulosin and nifedipine with 5％ (99/1 804)and 7％ (117/1 796) minor adverse effects respectively and less than 1％ severe adverse effects in both groups (RR =0.85,95％ CI 0.65-1.10, P =0.21;RR =0.49,95 ％ CI 0.09-2.59, P =0.40).Conclusion Compared to nifedipine, tamsulosin has higher stone expulsion rate and lower incidence rates for ESWL or URSL.Since there was no obvious adverse effects, tamsulosin could be considered as a preferable option for patients with LUS.