Recently our intensive attention has been drawn to the effects of the air pollution on the respiratory organs. The authers have studied the vital capacity and timed vital capacity of the adults and children living in the Spa (hydrogen sulfide containing acid Spring Kusatsu) and the sulfur mine where the atomospheric air contains a small quantity of H₂S under 2ppm in spa and SO₂ under 1ppm in spa, and following results were obtained;
1. There was no significant difference in height and body weight among the children in the mine, the spa and the control district.
2. In the mine, many children complained of subjective symptoms concerning the respiratory organs.
3. Elevated vital capacity was found in the mine children.
4. There was no significant difference in the timed vital capacity between the control and the spa children.
5. In the control and the spa, the height showed the highest correlation to the vital capacity with men and the body weight to the vital capacity with women.
Concerning the partial correlation except the age factor, there was a higher correlation between the vital capacity and body weight than between the vital capacity and the height both with boys and girls.
6. Our results supported the Hewlett-Jackson's fomula in regression equation which can be used to predict the vital capacity.
7. There was no significant difference in the vital capacity of the residents between the two mines, which have different environmental and occupational conditions each other.
8. Concerning the timed vital capacity, there was no significant difference between these mines, but it was lower in the mine workers than in the office workers of the mine.
9. No significant difference in the timed vital capacity was proved between the smoker and non-smoker in the mine.

Manganese (Mn) intoxication is known to induce parkinsonism. Mn-induced parkinsonism preferentially affects the globus pallidus in contrast to idiopathic parkinsonism where the degeneration predominantly involves the nigral pars compacta. We present three patients who had been occupationally exposed to Mn and developed parkinsonism, and one patient who had been exposed to long-term Mn and was proven to have idiopathic parkinsonism. All the manganism patients had a particular propensity to fall in a backward gait and a prominent postural instability compared with the severity of other parkinsonian features. Case 1 also showed a cock walk and dystonic features, quite characteristic findings of manganism. The rigidity, another important parkinsonian sign, was not found in all three manganism patients. There was no sustained therapeutic response to levodopa. A [18F]6-fluoro-L-dopa (6FD) PET scan performed in case 1 was normal in contrast to a reduced uptake in the striatum of the patient with idiopathic parkinsonism. These cases indicate that Mn-induced parkinsonism can be differentiated from idiopathic parkinsonism in that the former has unique clinical features and a normal 6FD PET scan.
Gait ; Globus Pallidus ; Humans ; Levodopa ; Manganese* ; Occupations ; Parkinsonian Disorders* ; Positron-Emission Tomography

Background/Aims: Recent studies indicate that probiotics, which have attracted attention as a treatment for irritable bowel syndrome, affect intestinal homeostasis. In this study, we investigated whether Zygosaccharomyces sapae (strain I-6), a probiotic yeast isolated from miso (a traditional Japanese fermented food), could improve irritable bowel syndrome symptoms. Methods: Male Wistar rats were exposed to water avoidance stress (WAS). The number of defecations during WAS and the visceral hypersensitivity before and after WAS were evaluated using colorectal distension. Tight junction changes were assessed by Western blotting. Some rats were fed with strain I-6 or β-glucan from strain I-6. Changes in the intestinal microbiota were analyzed.The effect of fecal microbiota transplantation after WAS was evaluated similarly. Caco-2 cells were stimulated with interleukin-1β and tight junction changes were investigated after coculture with strain I-6. Results: The increased number of stool pellets and visceral hypersensitivity induced by WAS were suppressed by administering strain I-6. The decrease in tight junction protein occludin by WAS was reversed by the administration of strain I-6. β-Glucan from strain I-6 also suppressed those changes induced by WAS. In the rat intestinal microbiota, treatment with strain I-6 altered the β-diversity and induced changes in bacterial occupancy. Upon fecal microbiota transplantation, some symptoms caused by WAS were ameliorated. Conclusions These results suggest that traditional fermented foods such as miso in Japan are valuable sources of probiotic yeast candidates, which may be useful for preventing and treating stress-induced visceral hypersensitivity.

We report a case of a 64-year-old woman with a history of radiation therapy for breast cancer 27 years ago who developed malignant pericardial mesothelioma. Since 3 years ago, the recurrent bloody pericardial effusion was getting worse, which caused general edema and nocturnal dyspnea. She had a thickened pericardium and the right ventricular pressure curve showed a dip-and-plateau pattern. We diagnosed constrictive pericarditis and performed a pericardiectomy and waffle procedure on the thickened epicardium without cardiopulmonary bypass. The post-operative histology confirmed malignant pericardial mesothelioma and she died on the 17th postoperative day. Pericardial malignant mesothelioma is a rare disorder but very aggressive. This fatal disease may be considered in a patient with recurrent bloody pericardial effusion who has a history of thoracic radiation therapy.

We report the case of a 55-year-old man who received a hard blow to his chest from a liquid nitrogen hose that caused traumatic aortic dissection (Stanford type A, DeBakey type II). He did not have any other hemorrhagic injury ; therefore, we decided to perform an emergency surgery. The postoperative course was uneventful, and he was discharged on postoperative day 19. Pathological findings were compatible with traumatic aortic dissection. Blunt thoracic aortic injury is a potentially life-threatening injury ; therefore, it is worth remembering that relatively low-energy blunt trauma can cause aortic injury in patients with severe atherosclerosis. The optimal timing of intervention should be individualized in traumatic aortic injury with consideration of associated injuries.