1.Heterogeneity of non-cystic-fibrosis bronchiectasis in multiethnic Singapore: A prospective cohort study at a tertiary pulmonology centre.
Si Ling YOUNG ; Youxin PUAN ; Si Yuan CHEW ; Salahudeen Mohamed HAJA MOHIDEEN ; Pei Yee TIEW ; Gan Liang TAN ; Mariko Siyue KOH ; Ken Cheah Hooi LEE
Annals of the Academy of Medicine, Singapore 2021;50(7):556-565
INTRODUCTION:
Non-cystic fibrosis bronchiectasis (NCFB) is a highly heterogenous disease. We describe the clinical characteristics of NCFB patients and evaluate the performance of Bronchiectasis Severity Index (BSI) in predicting mortality.
METHODS:
Patients attending the bronchiectasis clinic between August 2015 and April 2020 with radiologically proven bronchiectasis on computed tomography were recruited. Clinical characteristics, spirometry, radiology, microbiology and clinical course over a median period of 2.4 years is presented.
RESULTS:
A total of 168 patients were enrolled in this prospective cohort study. They were predominantly women (67.8%), Chinese (87.5%) and never-smokers (76.9%). Median age of diagnosis was 64 years (interquartile range 56-71) and the most common aetiology was "idiopathic" bronchiectasis (44.6%). Thirty-nine percent had normal spirometries. Compared to female patients, there were more smokers among the male patients (53.8% versus 8.5%,
CONCLUSION
The NCFB cohort in Singapore has unique characteristics with sex differences. Over half the patients had a history of haemoptysis. The BSI score is a useful predictor of mortality in our population.
Aged
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Bronchiectasis/epidemiology*
;
Cohort Studies
;
Female
;
Fibrosis
;
Humans
;
Male
;
Middle Aged
;
Prospective Studies
;
Pulmonary Medicine
;
Severity of Illness Index
;
Singapore/epidemiology*