1.Clinical analysis of emergency coronary after interventional reperfusion arrhythmia
Kelan ZHA ; Yu ZENG ; Jiafu LI
Chongqing Medicine 2014;(7):798-800
Objective To explore the characteristics of the reperfusion arrhythmia after acute myocardial infarction (AMI) pa-tients underwent emergency coronary interventional therapy ,in order to reduce the incidence of serious arrhythmia ,and improve the prognosis and quality of life .Methods Clinical data of 147 patients from January 2009 to May 2012 with acute myocardial infarction occurrence reperfusion arrhythmia after underwent emergency coronary interventional treatment were analyzed .Results In 147 ca-ses ,62 cases of reperfusion arrhythmia occurred .Infarct-related artery for the left anterior descending branch (LAD) 33 patients (LAD group ) ,left circumflex artery (LCX) 7 cases (LCX group ) after surgery ,the right coronary artery(RCA) 22 cases (RCA group) .The tachyarrhythmia in LAD group was higher than RCA group(P<0 .05);the bradyarrhythmia in RCA group was higher than LAD group (P<0 .05) .Opening of the infarct-related artery<6 h arrhythmia had 43 cases occurred ,and >6 h arrhythmia had 19 cases occurred ;Arrhythmia after acute myocardial infarction occurred mainly in infarct related artery opened earlier .Conclusion AMI occurrence reperfusion arrhythmia after underwent emergency coronary interventional treatment have high incidence ,there is a correlation between the arrhythmia type and infarct-related artery ,also has a correlation between incidence and reperfusion time .
2.Transforming of the drug resistance plasmid from Staphylococcus aureus into Escherichia coli.
Wan-kelan LI ; Hong JIANG ; Yong-fen HUANG ; Xue-qin WAN
Journal of Southern Medical University 2010;30(11):2482-2484
OBJECTIVETo discuss the possible mechanism of drug resistance transmission between Staphylococcus and Escherichia coli.
METHODSThe chloramphenicol resistance plasmid of Staphylococcus aureus was extracted to transform the sensitive Escherichia coli, and the drug-resistant Escherichia coli were screened by drug sensitivity test.
RESULTSThe drug-resistant Escherichia coli were successfully obtained.
CONCLUSIONStaphylococcus may have a natural shuttle plasmid of drug resistance, which can transform Escherichia coli under specific conditions.
Drug Resistance, Bacterial ; genetics ; Escherichia coli ; drug effects ; genetics ; Plasmids ; Staphylococcus ; genetics ; Transformation, Bacterial
3.Isolation of a wild-type virulent phage of Helicobacter pylori and its simulated treatments of gastrointestinal Hp in vitro.
Xue-qin WAN ; Dong-sheng TANG ; Ai-ping LIU ; Shu-yi TAN ; Wan-kelan LI ; Jia KUANG ; Hong-ming LI
Journal of Southern Medical University 2011;31(2):304-307
OBJECTIVETo isolate the wild-type virulent phage of Helicobacter pylori (Hp) and simulate the treatments in vitro to investigate the methods for oral Hp-assisted penetration of the phage through the gastric barrier and offspring phage release for infection and treatment of gastrointestinal Hp.
METHODSThe Hp strain was cultured with the candle cylinder method and the virulent phage was isolated by single plate or double plate experiment. A simulated gastric juice was applied and the bactericidal effect of the phage was tested with double flats experiment.
RESULTSAfter a 1.5-h treatment in simulated gastric juice, the orally derived Hp-borne phage was still capable of forming plaques while the control phage was not.
CONCLUSIONThe oral Hp can help the phage resist the gastric juice and then infect the gastrointestinal Hp.
Bacteriophages ; isolation & purification ; physiology ; Gastrointestinal Tract ; microbiology ; Helicobacter Infections ; therapy ; Helicobacter pylori ; virology ; Humans ; Virulence
4.Study on the association of lecithin cholesterol acyltransferase gene polymorphisms with the lipid metabolism in coronary atherosclerotic heart disease.
Kelan ZHANG ; Sizhong ZHANG ; Keqin ZHENG ; Yong HE ; Li ZHANG ; Zhiguang SU ; Yan SUN ; Jiajun SHI ; Xiangdong KONG ; Yu TONG
Chinese Journal of Medical Genetics 2003;20(2):135-137
OBJECTIVETo examine the distribution of 3 polymorphisms of lecithin cholesterol acyltransferase gene in Chinese population and the association of these polymorphisms with lipid metabolism in patients with atherosclerotic heart disease (CHD).
METHODSGenotypes and frequencies of 3 sites were examined by PCR-restriction fragment length polymorphism technique in 209 unrelated normal control individuals and 203 CHD patients.
RESULTSThe observed allele frequencies conform well to Hardy-Weinberg equilibrium. The frequency of 608T allele was significantly higher in controls than that in patients (P=0.034). Compared with the CHD patients without 608T, the CHD patients with 608T exhibited a significant increase in plasma HDL-C concentration (P=0.015). 911T/C and 1188C/T polymorphisms were not found in either group.
CONCLUSION608T polymorphism of LCAT gene was associated with higher plasma HDL-C level in CHD patients, while 911T/C and 1188C/T polymorphisms maybe very rare in Chinese population.
Alleles ; China ; Cholesterol ; blood ; Cholesterol, HDL ; blood ; Cholesterol, LDL ; blood ; Cholesterol, VLDL ; blood ; Coronary Artery Disease ; enzymology ; genetics ; DNA ; genetics ; metabolism ; DNA Restriction Enzymes ; metabolism ; Female ; Gene Frequency ; Genotype ; Humans ; Lipid Metabolism ; Lipids ; blood ; Male ; Middle Aged ; Phosphatidylcholine-Sterol O-Acyltransferase ; genetics ; metabolism ; Polymorphism, Genetic ; Polymorphism, Restriction Fragment Length ; Triglycerides ; blood
5.Surgical management of minor salivary gland tumors.
Liang ZHOU ; Xiaoling CHEN ; Weiting HUANG ; Kelan LI ; Xiaotong ZHANG ; Wei WANG
Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2007;21(21):963-965
OBJECTIVE:
To study the clinical features of minor salivary gland tumors and to discuss the treatment modalities for these tumors.
METHOD:
Retrospective analysis of 54 cases with minor salivary gland tumor operated in our hospital from 1997 to 2004.
RESULT:
Among 54 cases with minor salivary gland tumors in this series, 16 patients lost of follow up. Among the remaining 38 patients, 2 patients with nasal cavity adenoid cystic carcinoma died of tumor recurrence 2 and 3 years after the surgery respectively, one patient with laryngeal myoepithelial carcinoma died of tumor recurrence 3 years after the surgery and one patient with paranasal sinus mucoepidermoid carcinoma died of recurrence 17 months after the surgery. Two patients with paranasal sinus adenoid cystic carcinoma recurred after the primary surgery and were survived without tumor after salvage surgery. The other patients survived with no tumor recurrence.
CONCLUSION
While different histopathology of minor salivary gland tumors were found in this group, malignant tumors were predominant, accounting for 81.4%. The choice of treatment for minor salivary gland tumors depends upon the location and the histopathology of the tumors. The treatment policy for benign tumors is simple tumor excision, while that for malignant tumors is surgery combined with pre- or post-operative radiation therapy. Complete surgical resection of tumor masses and tumor free margin is essential for successful treatment of malignant minor salivary gland tumors.
Adolescent
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Adult
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Aged
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Female
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Humans
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Male
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Middle Aged
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Retrospective Studies
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Salivary Gland Neoplasms
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surgery
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Salivary Glands, Minor
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surgery
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Treatment Outcome
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Young Adult