Objective To understand the spatial and temporal distribution of HIV/AIDS in Hubei province,and provide scientific evidence for the prevention and control of AIDS.Methods GeoDa software was used for autocorrelation analysis,SatScan 9.2 software was used for statistical analysis of spatial scanning,and finally geographic information system was used for visualization.Results A total of 6 952 HIV/AIDS cases were reported during 2010-2013 in Hubei,and the spatial autocorrelation analysis showed that Global Moran's I index was 0.266 (P＜0.05),indicating that there was a positive spatial autocorrelation of HIV/AIDS.Global Moran's I index increased year by year (P＜ 0.05),indicating that the increased spatial aggregation of HIV/AIDS during 2010-2013.The local Moran's I index showed that "high-high" clustering areas were in Wuhan,and the number of "high-high" clustering areas increased during 2010-2013.Moreover,the "high-high" clustering areas expanded from Wuhan to surrounding areas.Spatial and temporal scan analysis revealed that 19 counties in Wuhan,Huangshi,Ezhou,Xianning with a radius of 60.01 km (LLR=625.14,RR=3.23) were the main spatial and temporal clustering area during 2012-2013.Conclusion The spatial changes of HIV/AIDS seemed to be regular from 2010 to 2013 in Wuhan,spatial correlation at provincial level decreased and the "high-high" clustering areas gradually expanded from Wuhan to surrounding areas,indicating that it is necessary to strengthen the AIDS prevention and control in these areas in Hubei.