Objective To research the change rule of peripheral serum Th1/Th2/Th17 balance and relevant cytokines in atopic dermatitis(AD) and to further study its immunologic mechanism .Methods The levels of peripheral serum IFN‐γ,IL‐4 ,IL‐17 ,IL‐21 and IL‐23 in the patients with AD were detected by the flow immunofluorescence technology and the detection results were performed the statistical analysis ,thus the change rule of Th1/Th2/Th17 balance in AD was analyzed .Results The IL‐4 level in peripheral serum of the patients with AD was increased compared with the healthy control group (P<0 .05);the IFN‐γ/IL‐4 and IFN‐γ/IL‐17 in the AD group were significantly decreased compared with the control group (P<0 .01);IL‐17 was positively corre‐lation with SCORAD scores of AD severity (P<0 .05) .Conclusion Th1/Th2 and Th1/Th17 are decreased in the AD course .Th1/Th2/Th17 balance drift may be the important mechanism of AD pathogenesis .

Objective? To explore the application methods and effects of early postoperative activities on patients undergoing neurosurgery. Methods? Totally 101 postoperative patients from the Department of Neurosurgery of a Class Ⅲ Grade A hospital in Beijing between June and August 2018 were selected as a control group, while 110 postoperative patients between September and November 2018 were selected as an observation group by convenient sampling. Patients in the control group received routine postoperative care, while patients in the observation group did early post-operative activities. The effects of early off-bed activities such as the time of first early off-bed activity, the frequency of daily off-bed activities and the total time of off-bed activities every day as well as postoperative outcome indicators such as the interval from first off-bed activity to discharge, ability of daily living (ADL) at discharge and hospitalization expenses were compared between the two groups postoperatively. Results? For the effects of early off-bed activities, the time of first off-bed activity and the total time of off-bed activities every day in the observation group were better than those in the control group, and there were statistically significant differences between the two groups (Z/t=-3.300,2.418;P＜0.05). After care for early postoperative activities, the median of patients' time of early off-bed activities were reduced from 27.0 h to 24.0 h, and total time of off-bed activities every day were increased from (1.06±0.72) h to (1.27±0.70) h. In terms of patients' postoperative outcomes, the interval from first off-bed activity to discharge, ADL at discharge and hospitalization expenses, there were statistically significant differences between the two groups (Z/t=-3.356,4.428,-3.316;P＜0.05). The median of patients' interval from first off-bed activity to discharge were decreased from 55.0 h to 39.3 h. Conclusions? Early postoperative activities can improve the motor ability of neurosurgical patients, shorten their length of hospital stay, and reduce their hospitalization expenses,thus enabling the patients' quicker recovery.

Objective To investigate the effects of the third-generation mechanical chest compressor on outcomes of cardiopulmonary resuscitation in patients with out-of-hospital cardiac arrest.Methods The patients with out-of-hospital cardiac arrest from October 2015 to September 2017 in the Yuyao peoples' hospital were included and divided randomly into 2 groups:manual chest compression group and mechanical chest compression group.The duration of resuscitation,the rate of restoration of spontaneous circulation (ROSC),4-h survival rate and the rate of survival getting to hospital discharge with favorable neurological status of two groups were analyzed.Results A total of 95 patients with out-of-hospital cardiac arrest were included.The rate of ROSC and 4-h survival was significantly increased in the mechanical chest compression group compared with the manual chest compression group (P＜0.05).There was no remarkable difference in the duration of resuscitation and the rate of survival getting to hospital discharge with favorable neurological status between 2 groups.Conclusions The thirdgeneration mechanical chest compressor significantly improves the rate of ROSC and the shout-term survival in patients with out-of-hospital cardiac arrest.