Examination of feces and deworming were carried out five times every other month between May 1962 to February 1963 in 5 communities (a total of 202 households, 1, 050 inhabitants) of Urakawa, Sakumamachi, Shizuoka Prefecture. After about a year has elapsed, in which no countermeasures were taken, examination of feces was carried out again in January 1964 to study a change in the rate of positivity. Examination was carried out by the cellophane thick layer smear method (values obtained with two sheets).
(1) The rate of positivity for Ascaris eggs ranged from 13.7% to 55.1%, with an average of 28.0% in the initial examination. The rate was higher in two commnities in the mountainous district. By sex and age, the rate was high among infants, school boys and adult females.
(2) A study of the change in the rate of positivity during the two years has shown that the rates of reinfection and new infcction were higher in communities where the rate of positivity was higher in the initial examination, indicating how difficult it is to exterminate Ascaris infection. On the contrary, there was no substantial rise in the rate of positivity in communities where the rate of positivity in the initial examination was under 10%(3 out of 5 communities), even though no countermeasures were taken during the period of one year. This seems to show that it is not required to carry out deworming frequently.
It has been found that the rate of Ascaris infection was lower in communities where persons positive for unfertilized eggs alone accounted for higher percentages among the total of persons positive for Ascaris eggs, there being a marked inverse corelation between persons positive for unfertilized eggs alone and persons positive for all kinds of Ascaris eggs. There has been a marked tendency to familial concentration of Ascaris infection.
(3) The results of the present study have shown that, in taking measures to exterminate Ascaris infection, it is necessary to take into consideration the rate of positivity for Ascaris eggs, the ratio of persons positive for unfertilized Ascaris eggs to persons positive for all kinds of Ascaris eggs, and a tendency to familial concentration of infection in the community.

Since the discovery of the first strain in 1961 in England, MRSA, the most notorious multidrug-resistant hospital pathogen, has spread all over the world. MRSA repeatedly turned down the challenges by number of chemotherapeutics, the fruits of modern organic chemistry. Now, we are in short of effective therapeutic agents against MRSA prevailing among immuno-compromised patients in the hospital. On top of this, we recently became aware of the rise of diverse clones of MRSA, some of which have increased pathogenic potential compared to the classical hospital-associated MRSA, and the others from veterinary sources. They increased rapidly in the community, and started menacing otherwise healthy individuals by causing unexpected acute infection. This review is intended to provide a whole picture of MRSA based on its genetic makeup as a versatile pathogen and our tenacious colonizer.
Adenosine ; Chemistry, Organic ; Chromatography, Micellar Electrokinetic Capillary ; Clone Cells ; Colon ; England ; Fruit ; Humans ; Methicillin ; Methicillin Resistance ; Methicillin-Resistant Staphylococcus aureus ; Sprains and Strains ; Staphylococcus ; Staphylococcus aureus

The objective of this study is to examine the effect of low-magnitude, high-frequency (LMHF) loading, and anti-osteoporosis medications such as parathyroid hormone (PTH) and bisphosphonates on peri-implant bone healing in an osteoporosis model, and to assess their combined effects on these processes. Thirteen-week-old ovariectomized rats (n = 44) were divided into three groups: PTH, alendronate, and saline. After 3 weeks of drug administration, titanium implants were inserted into the tibiae. Each group was subdivided into two groups: with or without LMHF loading via whole-body vibration (50 Hz at 0.5 g, 15 min per day, 5 days per week). Rats were killed 4 weeks following implantation. Removal torque test, micro-CT analyses (relative gray (RG) value, water = 0, and implant = 100), and histomorphometric analyses (bone-to-implant contact (BIC) and peri-implant bone formation (bone volume/tissue volume (BV/TV))) were performed. Removal torque values and BIC were significantly differed by loading and drug administration (ANOVA). Post hoc analysis showed that PTH-treated groups were significantly higher than the other drug-treated groups. BV/TV was significantly enhanced by PTH administration. In cortical bone, RG values were significantly increased by loading. In trabecular bone, however, RG values were significantly increased by PTH administration. These findings suggest that LMHF loading and PTH can act locally and additively on the bone healing process, improving the condition of implant osseointegration.
Alendronate ; administration & dosage ; pharmacology ; Animals ; Dental Implantation, Endosseous ; methods ; Dental Implants ; Female ; Implants, Experimental ; Osseointegration ; drug effects ; Ovariectomy ; Parathyroid Hormone ; administration & dosage ; pharmacology ; Rats ; Tibia ; surgery ; Vibration ; Wound Healing ; drug effects