· Since 1975 the Morishita Worldwide Longevity Regions Research Delegation has conducted in the regions of Caucusus, Hunza and Vilcabamba several times per annum.
· In 1984, we designated Xinjiang Uygur as the world's fourth longevity region.
· In 1987, we named the regions of Caucusus, Middle Asia, on the periphery of Pamir plateau (including Hunza) and the area extends for 8, 000km from east to west in latitude about 40° N “The Silk Road Lon-gevity Region”. And we presented of the results of our research at the 16th Natural Medicine International Symposium.
· In 1991, we have conducted on the spot research of Pama of Guangxi district. In the process, we designated this area as the world's fifth longevity region.
We proved that most longevitists of more than 100 years live along the Silk Road and have a lot in com-mon. That is, they eat unpolished grains as a staple diet and do not live far from the place of their birth. And they also eat crops they cultivate themselves. Life energy, the healthy condition of the earth revealing morpho-logically interdependent life pattern found in their living, has cycled in the uncivilized longevities.

Objective: We previously showed that interstitial lung disease, pneumonia, abnormal liver function, and anaphylactic reactions were frequent adverse events, and we analyzed outcomes, suspected causative drugs, and the onset of adverse events using information derived from the “Japanese Adverse Drug Event Report” (JADER) database.  Here, we aimed to determine the status of actual adverse reactions to carbamazepine (CBZ) and lamotrigine (LTG) using national public databases.
Methods: Data from the “Information on Decision on Payment/non-payment of Adverse Reaction Relief Benefits” (IARRB; April 2012-March 2016) and JADER (April 2012-March 2016) databases were downloaded from the website of the Pharmaceuticals and Medical Devices Agency.  Information from the national database of the “Health Insurance Claims and Specific Health Checkups of Japan” (NDB) (April 2014-March 2015) was downloaded from the website of the Ministry of Health, Labour and Welfare.
Results: The numbers of females and males in the IARRB were 169 and 229, respectively, for CBZ and 135 and 56, respectively, for LTG.  Those in JADER were 1,152 and 1,352, respectively, for CBZ and 1,358 and 806, respectively, for LTG.  The respective ratios of males and females prescribed CBZ and LTG in the NDB were 46.2 and 53.8%, and 56.3 and 43.7%, respectively.  Both CBZ and LTG were identified as very high-risk drugs associated with extreme skin reactions such as drug-induced hypersensitivity syndrome (DIHS), toxic epidermal necrolysis (TEN), Stevens-Johnson syndrome (SJS), erythema multiforme type drug eruption (EM), and disseminated papuloerythematous drug eruption (DPE).  CBZ induced DIHS, EM, and DPE more frequently among elderly men (over 60 years old), whereas LTG induced these reactions in women of reproductive age.
Conclusions: Elderly men prescribed CBZ and women of reproductive age prescribed LTG should be advised about extreme adverse skin reactions.

The.progress in diagnosis and surgical treatment of gastric cancer contributes to the raised diagnosis rate and 5-year survival rate of gastric cancer patients in Japan. According to the clinical data of 273 142 Japanese gastric cancer patients from 1962 to 1991, the proportion of patients with stage I gastric cancer was increased from 22.5% to 58.1%, and the accumulative 5-year survival rate from 37.5% to 68.8%. The improvement of the accumulative 5-year survival rate was remarkable for patients with stage Ⅱ gastric cancer (from 47.7% to 70.3%) and stage Ⅲ gastric cancer (from 26.4% to 45.0%).

Thirteen female swimmers (ranging in age from 15 to 18 years) were selected as subjects and divided into two groups; group A (subjects of experiment) consisted of six subjects in whom low pressure was loaded and group B (subjects of control) consisted of seven in whom low pressure was not given.
During training, circuit weight training was performed in a low pressure environment and it was combined with conventional swimming training. We studied the effect of these types of training on their red-cell 2, 3-diphosphoglycerate, salivary cortisol, and plasma testosterone.
(1) The 2, 3-DPG level showed a greater increase after loading exercise than at the time of resting in both groups A and B. The increase was highly significant in group A. Additionally, 10 days after the removal of the loading, hemoglobin and hematocrit levels were significantly decreased in groups A and B, and a significant increase in 2, 3-DPG was observed in group A.
(2) Only after loading low pressure was the cortisol level higher in group A than in group B. However, there was no significant difference between the two groups in the amount of exercise loading when heart rate was used as the index.
(3) Testosterone tended to show a greater increase after exercise loading than on the first day of the experiment. However, neither an effect of exposure to low pressure on testosterone nor a significant difference between the two groups was observed.
According to the results, in swimming, an endurance contest, physical changes during training are almost the same in group A and B, but it is considered that a concurrent severe hypoxic condition as a result of low pressure loading brings about homeostasis in the living body and the homeostasis leads to an attempt to increase oxygen uptake by the tissues, yeilding increased staying power.

In April 2000, the nursing care insurance law was enforced in Japan. From April 1999 to March 2005, 162 residents including those receiving short-stay services in the Kamitsuga geriatic health services facility visited the hospital because of injuries resulting from falls. Thirty-one cases were diagnosed as fractures of femur, 13 as fractures of spine, 10 as fractures of upper extremities, 10 as fractures of rib and 3 as subdural hematomas. Fracture accounted for 48% of all cases, and femur accounted for 40% of all fracture cases. Annual hospital visits and hospitalization frequencies kept increasing up to 2001, then turned flat after 2002, and decreased in 2004. After 2002 we took the following measures, (1) individualized care, (2) small group care and (3) analysis of the behavior of inmates with an action chart for the first seven days. These measures resulted in the decrease of falls. After 2002 injuries to lower extremities decreased, but injuries to trunk increased. Generally Fractures of lower extremities prevails in the elderly of high-ADL (activity of daily life), and fractures of trunk prevails in the elderly of low-ADL. The above-mentioned three measures were effective for those of high-ADL, but ineffective for those of low-ADL. Other measures for those of low-ADL are necessary in the future.
Activities of Daily Living ; Fall, NOS ; Legal system ; Care given by nurses ; Insurance

Maoto has been reported to be effective in controlling fever caused by influenza. But Maoto's effects on respiratory complications of influenza have been unknown so far. We performed a comparative study on the respiratory complication (bronchitis, pneumonia, asthma attack) rates of pediatric cases of influenza after the administration of Maoto (n = 80), Oseltamivir or Zanamivir (n = 166). Rate of using other respiratory medication at the same time is higher in Oseltamivir/Zanamivir group (64/166 = 39%) than Maoto one (12/80 = 15%) (P < 0.01). Respiratory complication rates were equal between Maoto group (34/166 = 21%) and Oseltamivir/Zanamivir one (9/80 = 11%) (P = 0.07). In the patients who had not history of bronchial asthma, respiratory complication rate is higher in Oseltamivir/Zanamivir group (19/107 = 18%) than Maoto one (4/67 = 6%) (P = 0.045). In the patients who had history of bronchial asthma and age under10, respiratory complication rate is higher in Maoto group (4/5 = 80%) than Oseltamivir/Zanamivir one (15/57 = 26%) (P = 0.047).

A 50-year-old man had undergone an initial original Bentall operation 19 years previously and replacement of the descending thoracic aorta 3 years previously. Computed tomography and an angiogram revealed a distal arch aneurysm and an ascending aortic aneurysm, neither of which had been detected 3 years previously. Detached anastomosis of the distal site and both coronary ostia were confirmed in the operation. Redo aortic root replacement and total arch replacement were performed successfully. His postoperative course was excellent.