· Since 1975 the Morishita Worldwide Longevity Regions Research Delegation has conducted in the regions of Caucusus, Hunza and Vilcabamba several times per annum.
· In 1984, we designated Xinjiang Uygur as the world's fourth longevity region.
· In 1987, we named the regions of Caucusus, Middle Asia, on the periphery of Pamir plateau (including Hunza) and the area extends for 8, 000km from east to west in latitude about 40° N “The Silk Road Lon-gevity Region”. And we presented of the results of our research at the 16th Natural Medicine International Symposium.
· In 1991, we have conducted on the spot research of Pama of Guangxi district. In the process, we designated this area as the world's fifth longevity region.
We proved that most longevitists of more than 100 years live along the Silk Road and have a lot in com-mon. That is, they eat unpolished grains as a staple diet and do not live far from the place of their birth. And they also eat crops they cultivate themselves. Life energy, the healthy condition of the earth revealing morpho-logically interdependent life pattern found in their living, has cycled in the uncivilized longevities.

Objective: We previously showed that interstitial lung disease, pneumonia, abnormal liver function, and anaphylactic reactions were frequent adverse events, and we analyzed outcomes, suspected causative drugs, and the onset of adverse events using information derived from the “Japanese Adverse Drug Event Report” (JADER) database.  Here, we aimed to determine the status of actual adverse reactions to carbamazepine (CBZ) and lamotrigine (LTG) using national public databases.
Methods: Data from the “Information on Decision on Payment/non-payment of Adverse Reaction Relief Benefits” (IARRB; April 2012-March 2016) and JADER (April 2012-March 2016) databases were downloaded from the website of the Pharmaceuticals and Medical Devices Agency.  Information from the national database of the “Health Insurance Claims and Specific Health Checkups of Japan” (NDB) (April 2014-March 2015) was downloaded from the website of the Ministry of Health, Labour and Welfare.
Results: The numbers of females and males in the IARRB were 169 and 229, respectively, for CBZ and 135 and 56, respectively, for LTG.  Those in JADER were 1,152 and 1,352, respectively, for CBZ and 1,358 and 806, respectively, for LTG.  The respective ratios of males and females prescribed CBZ and LTG in the NDB were 46.2 and 53.8%, and 56.3 and 43.7%, respectively.  Both CBZ and LTG were identified as very high-risk drugs associated with extreme skin reactions such as drug-induced hypersensitivity syndrome (DIHS), toxic epidermal necrolysis (TEN), Stevens-Johnson syndrome (SJS), erythema multiforme type drug eruption (EM), and disseminated papuloerythematous drug eruption (DPE).  CBZ induced DIHS, EM, and DPE more frequently among elderly men (over 60 years old), whereas LTG induced these reactions in women of reproductive age.
Conclusions: Elderly men prescribed CBZ and women of reproductive age prescribed LTG should be advised about extreme adverse skin reactions.

The.progress in diagnosis and surgical treatment of gastric cancer contributes to the raised diagnosis rate and 5-year survival rate of gastric cancer patients in Japan. According to the clinical data of 273 142 Japanese gastric cancer patients from 1962 to 1991, the proportion of patients with stage I gastric cancer was increased from 22.5% to 58.1%, and the accumulative 5-year survival rate from 37.5% to 68.8%. The improvement of the accumulative 5-year survival rate was remarkable for patients with stage Ⅱ gastric cancer (from 47.7% to 70.3%) and stage Ⅲ gastric cancer (from 26.4% to 45.0%).

In 2011, we reported the usefulness of a database（DB）that was established by the members of a palliative care team（PCT）. Since then, we updated DB depending on the requests of PCT. We revised DB mentioned below. We developed a form for keeping a record of PCT members’care for patients, their family members or others, and a record of recommendation for each problem list. We also updated another form so that the evaluation of Support Team Assessment Schedule of Japan（STAS-J）had been showed sequentially, added an entry form of Palliative Prognostic Index, and extracted data required by Japan Society for Palliative Medicine in order to evaluate the activity of PCT. The database could be used by many hospitals, because it was created by the commercially available software.

[Objective]The purpose of this study was to clarify the current status of cooperation between acupuncturists and physicians providing palliative care at home care support clinics.
[Methods]We studied 297 home care support clinics that provide cancer palliative care in the home. We mailed a self-administered questionnaire to the physicians belonging to the clinics. The questionnaire was created to clarify the number of clinics that provide home palliative care, current status of cooperation with acupuncturists, and methods of information-sharing.
[Results]We received responses from 98 clinics (33.3%response rate). Of these, 14 clinics (14.3%) currently provide care for terminal cancer patients in cooperation with acupuncturists, 9clinics (9.2%) reported having done so in the past. Patient's conditions treated in cooperation with acupuncturists were things such as pain, hiccups, edema, ascites, and constipation. The benefits attributed to cooperation with acupuncturists included "relief of symptoms,""improved patient satisfaction,"and "improved patient motivation."Regarding the presence or absence of information-sharing with acupuncturists, 7clinics (50%) responded that they "always share," 7clinics (50%) responded that they "share depending on the situation,"and no clinic reported "does not share information."Regarding the prospect for cooperation with acupuncturists in providing home palliative care in the future, 9clinics (9.2%) responded that they "actively want to cooperate,"and 65 clinics (66.3%) stated that they would "think about cooperation in some circumstances."
[Conclusion]From this study, it was concluded that cooperation exists between acupuncturists and physicians in 14.3%of home care support clinics providing palliative care. In addition, the possibility that cooperative patient care provides not only symptom relief but also other benefits has been suggested. On the other hand, it is necessary for acupuncturists, as part of a healthcare team, to have access to patient information and the status of other treatments, so that the acupuncturists can be involved in the field of home palliative care. Furthermore, management should promote an environment for cooperating with professionals in other medical occupations, including physicians.

Thirteen female swimmers (ranging in age from 15 to 18 years) were selected as subjects and divided into two groups; group A (subjects of experiment) consisted of six subjects in whom low pressure was loaded and group B (subjects of control) consisted of seven in whom low pressure was not given.
During training, circuit weight training was performed in a low pressure environment and it was combined with conventional swimming training. We studied the effect of these types of training on their red-cell 2, 3-diphosphoglycerate, salivary cortisol, and plasma testosterone.
(1) The 2, 3-DPG level showed a greater increase after loading exercise than at the time of resting in both groups A and B. The increase was highly significant in group A. Additionally, 10 days after the removal of the loading, hemoglobin and hematocrit levels were significantly decreased in groups A and B, and a significant increase in 2, 3-DPG was observed in group A.
(2) Only after loading low pressure was the cortisol level higher in group A than in group B. However, there was no significant difference between the two groups in the amount of exercise loading when heart rate was used as the index.
(3) Testosterone tended to show a greater increase after exercise loading than on the first day of the experiment. However, neither an effect of exposure to low pressure on testosterone nor a significant difference between the two groups was observed.
According to the results, in swimming, an endurance contest, physical changes during training are almost the same in group A and B, but it is considered that a concurrent severe hypoxic condition as a result of low pressure loading brings about homeostasis in the living body and the homeostasis leads to an attempt to increase oxygen uptake by the tissues, yeilding increased staying power.