1. Association between high expression of intrahepatic programmed death-1 and liver inflammation in patients with autoimmune hepatitis
Kegong XIONG ; Kunyu KE ; Lifang CHEN ; Dahai WEI ; Xiaoqin LIN ; Li CHEN
Chinese Journal of Hepatology 2017;25(4):263-267
Objective:
To investigate the expression of programmed death-1 (PD-1) in liver tissue and its association with liver pathology in patients with autoimmune hepatitis (AIH).
Methods:
A total of 54 AIH patients (38 in the active stage and 16 in the remission stage) were enrolled, and 9 healthy volunteers were enrolled as control group. Immunohistochemistry combined with quantitative image analysis was used to measure the expression of PD-1 in liver tissue. The t-test, rank sum test, one-way analysis of variance, least significant difference t-test, Mann-Whitney U test, and Pearson relation analysis were used for statistical analysis of different types of data.
Results:
The AIH group had a significantly higher positive rate of PD-1 in liver tissue than the control group (13.57%±6.84% vs 2.22%±0.66%,