1.The History of Research in Vestibular Organ and Benign Paroxysmal Positional Vertigo
Korean Journal of Otolaryngology - Head and Neck Surgery 2021;64(7):457-466
Since B.C., vertigo had been described as a condition closely related to migraines or epilepsy. This perception remained during the 14th-16th century and vertigo was considered to be a symptom of brain disease. Until the 18th century, the perception remained that the vestibular organ would be in charge of hearing. However, during the 19th century, it was understood that the sense of equilibrium and vertigo might have been related to vestibular organs. Barany first mentioned positional vertigo and otolithic disease in 1921, and Dix and Hallpike defined their clinical characteristics in 1952. After studies from numerous otologists and neurologists, including Schuknecht and Epley, which identified benign paroxysmal positional vertigo (BPPV) has emerged as one of today’s most common diseases. The development of various test methods enabled more detailed diagnosis of BPPV. The treatment performance also improved significantly as various canalith repositioning procedures were introduced.
2.A Case of Cutaneous Horn-Like Cutaneous Focal Mucinosis.
Do Hyun LEE ; Baik Kee CHO ; Hyun Jeong PARK
Korean Journal of Dermatology 2012;50(11):1014-1015
No abstract available.
Mucinoses
3.Solitary Neurofibroma on the Lower Lip.
Do Hyun LEE ; Baik Kee CHO ; Hyun Jeong PARK
Korean Journal of Dermatology 2013;51(4):299-300
No abstract available.
Lip
;
Neurofibroma
4.Bilateral Congenital Curved Nail of the Fourth Toe.
Sewon HWANG ; Miri KIM ; Baik Kee CHO ; Hyun Jeong PARK
Korean Journal of Dermatology 2015;53(4):330-331
No abstract available.
Toes*
5.Bilateral Congenital Curved Nail of the Fourth Toe.
Sewon HWANG ; Miri KIM ; Baik Kee CHO ; Hyun Jeong PARK
Korean Journal of Dermatology 2015;53(4):330-331
No abstract available.
Toes*
6.Relationship between Vimentin Expression and Progression of Uterine Cervix Epithelial Neoplasms.
Sung Chul LIM ; Keun Hong KEE ; Hyun Jong PARK
Korean Journal of Pathology 1998;32(9):663-669
Vimentin is an intermediate filament protein normally expressed in mesenchymal cells, but the evidence of the aberrant expression of vimentin in epithelial cancer cells suggests that the vimentin expression might be related to local invasiveness and metastatic potential. There have been a few previous studies on the vimentin expression in human cervical carcinogenesis using in vivo and in vitro models. We examined the immunohistochemical vimentin expression in various squamous epithelial neoplasms of the uterine cervix, including the cervical intraepithelial neoplasia group (n=25), the microinvasive squamous cell carcinoma group (n=15), the invasive squamous cell carcinoma group (n=15) and the metastatic squamous cell carcinoma group (n=8). Vimentin positivity was significantly higher in the invasive than in the intraepithelial group, and in the cases with lymph node metastasis than in those without metastasis, suggesting a relationship between the vimentin expression and progression of the uterine cervical epithelial tumors.
Carcinogenesis
;
Carcinoma, Squamous Cell
;
Cervical Intraepithelial Neoplasia
;
Cervix Uteri*
;
Female
;
Humans
;
Intermediate Filaments
;
Lymph Nodes
;
Neoplasm Metastasis
;
Neoplasms, Glandular and Epithelial*
;
Vimentin*
7.Photoprotective Effect of Various Sunscreens Against Ultraviolet B - induced Chronic Skin Damage.
Hyun Joo CHOI ; Seung Kyung HANN ; Yoon Kee PARK
Korean Journal of Dermatology 1995;33(1):8-18
BACKGROUND: Chronic exposure to ultraviolet radiation(UVE) nduces photoaging characterized by dry, deeply wrinkled, inelastic, leathery, and irregulaity pigmented skin. UVR also induces solar keratosis and carcinoma, and is a contributing factor in melanoma. Sunscreens are used to prevent solar damage to skin and, if used on a daily lass should significantly reduce the incidence of the chronie photodamaging events. OBJECTIVE: We tried to evaulate the photoaging effects of UVR in the skin and the photoprotective effect of sunscreens. METHOD: We examined the gross and microscopic changes skin of albino hairless Skh : HR-1 mice exposed chronically to ultraviolet B(UVB) and suncreen-treated mice. RESULTS: The skin of the UVB-irradiated mouse shows chear, cteristic signs of photoaging, such as deep wrinkles across the back, and thickened and a hery skin. Histologically, the photoaged skin shows increased epidermal thickness, numeross fibroblasts and inflammatory cell infiltration in the upper dermis, and many enlarged keratering cysts in the lower dermis. By the 20th week, seven of the total of 9 mice(78%) in UVB irradiated mice developed at least one tumor. Histologically, the tumor is a papilloma, but the he are many dyskeratotic cells and loss of polarity in epidermis. Octyl methoxycinnamate or TiO ZnO Talc-treated mic show a significantly decreased wrinkling score, mimmal epidermal hyperplasia, slightly increased dermal cellularity, and lack of proliferation of cysts. The octyl dimethyl PABA-treatd mice shows significantly increased wrinkling score and marked inflammatory infiltration dermis. By the 20th week, only one mouse had developed a tumor in the octyl methoxy irmamate-treated group and no evidence of tumor was seen in the TiO ZnO Talc-treated group. In the octyl dimethyl PABA-treated group, five of 7 mice(71%) developed at least one tumor. CONCLUSION: The skin which is chronically exposed to UVB is subject to photoaging and photocarcinogenesis and regular use of an adequate sunscreen would prevent these photodamaging effects of UVB.
Animals
;
Dermis
;
Epidermis
;
Fibroblasts
;
Hyperplasia
;
Incidence
;
Keratosis
;
Melanoma
;
Mice
;
Mice, Hairless
;
Papilloma
;
Skin*
;
Sunscreening Agents*
8.Solitary Morphea Profunda with Incidental Acantholysis.
Young Min PARK ; Sang Hyun CHO ; Baik Kee CHO
Annals of Dermatology 1999;11(2):78-81
Solitary morphea profunda is a rare form of scleroderma, characterized clinically by a solitary sclerotic plaque, and histologically by marked dermal and subcutaneous fibrosis with an inflammatory infiltrate. We describe another case of this entity presented with an ulcerative, indurated plaque on the left iliac crest, which histologically revealed a focal incidental acantholysis in the overlying epidermis and a marked eosinophilic infiltration through the dermis to the sub-cutaneous tissue.
Acantholysis*
;
Dermis
;
Eosinophils
;
Epidermis
;
Fibrosis
;
Scleroderma, Localized*
;
Ulcer
9.A Case of Fabry ` s Disease with Generalized Anhidrosis.
Hyun Chul PARK ; Kee Chan MOON ; Soo Nam KIM
Korean Journal of Dermatology 1988;26(5):734-738
A 21-year-old male suffered from generalized anhidrosis and heat intolerance for about 15 years. Other clinical features included multiple angiokeratoma on the back, scrotum and extremities, together with ocular involvement. The electronmicroscopic studies of the skin demonstrated laminated intracytoplamic inclusions in the endothelial cells, pericytes of dermal vessels, fibroblasts and eccrine glandular cells. a Galactosidase assay of leukocytes from the patient and his uncle showed nearly absence of the activity,
Angiokeratoma
;
Endothelial Cells
;
Extremities
;
Fibroblasts
;
Galactosidases
;
Hot Temperature
;
Humans
;
Hypohidrosis*
;
Leukocytes
;
Male
;
Pericytes
;
Scrotum
;
Skin
;
Young Adult
10.A Study for A New Method for Evaluation of Phototoicity.
Hyun Chul PARK ; Kee Chan MOON ; Soo Nam KIM
Korean Journal of Dermatology 1988;26(5):629-635
The present study was carried out to find a simple and safe in. vitro test for phtotoxic drugs. Authors selected two strains of Salmonella typhimurium(TA98 and TA102) which have been used in Ames test for the detsction of mutagenecity af various chemical substances. Both strains are genuine products of genetic enzineering. The etrain TA98 should be highly vulnerable to ultraviolet radition because it lacks normal I)NA excision repair gene. The strain TA102 was chosen as control since it maintained the DNA repair gene. These strains were subjected to increasing dosea of UVA with or without pretreatment of 8 methoxypsoralsn(8-MOP) which is a prototype of photatoxic druge. The authors made use of a perforated stain-less steel template which provided a simple and eosy monitoring of ultraviolet irradiation effects i.e. clear zones due to inhibition of the atrains could be determined. By using this methad, the authors acquired the following results .' I. 8-MOP alone exerted no inhibition on both strains at concentration upto 100mg /ml. 2. UVA irradiation alone showed no growth inhibition at dose upto 5J/cm. 3. UVA irradiation after pretreatment with 8 MOP resulted varying growth inhibition in proportion to irradiation doses. 4. Authors found a suitable concentration of 8-MOP for this test is 10pg/ml. With this ccncentrstion, minimal phatatoxic dose of UVA were O.l J/cm for the strain TA98 and 1.0J/cm for the strain TA102 respectively.
Dermatitis, Phototoxic
;
DNA Repair
;
Methoxsalen
;
Salmonella
;
Steel