1.The effect of active pulmonary physiotherapy on postoperative pulmonary compliation.
Min Hwa CHONG ; Soon Chan HONG ; Woo Song HA ; Soon Tae PARK ; Ho Seong HAN ; Chung Kee LEE ; Jong Cheol KIM
Journal of the Korean Surgical Society 1992;43(3):354-363
No abstract available.
2.Arteriovenous fistula following lumbar laminectomy: a case.
Joong Hwan OH ; Chi Soon YOON ; Eun Kee KIM ; Chong Kook LEE ; Hae Yong LEE ; Keum Soo PARK ; Kyung Hoon CHOE
The Korean Journal of Thoracic and Cardiovascular Surgery 1991;24(6):605-609
No abstract available.
Arteriovenous Fistula*
;
Laminectomy*
3.The Isolation Arm Test for the Assessment of Neuromuscular Biockade ; Reevaluation of Injection Site Influencing to the Twitch Responses.
Sung Yell KIM ; Kyung Ho HWANG ; Sun Chong KIM ; Wook PARK ; Kee Ryang AHN ; Chun Sook KIM
Korean Journal of Anesthesiology 1992;25(4):755-759
The isolation arm test at upper limb for the study of muscle relaxants sensitivity of human muscle is described. In the healthy adults, succinylcholine 100ug/kg or vecuronium 5~6ug/kg combined with 20ml saline is given intravenously at various sites of injection while the circulation to the arm is occluded with upper arm pneumatic tournique. After injection of muscle relaxants, neuromuscular transmission is then studied by TOF stimulation to ulnar nerve with EMG monitor(ABM, Dates) and changes of twitch response in evoked muscle action potential amplitude from hypothenar muscle are recorded. In the results, twitch height is depressed weakly and slowly but incompletely after muscle relaxant is injected intravenously at cubital fossa, and declines further depression following recovery after the release of upper arm tourniquet occiuded systemic circulation(two stage response). There are not any changes of twitch response while muscle relaxants are given intravenously between upper arm and forearm pneumatic tourniquet. But twitch height is depressed rapidely and completely after muscle relaxants are given intravenously at doris hand under the upper arm or forearm pneumatic tourniquet. Conclusively, twitch response under the isolation arm test is influenced from the site of injection, and in order to obtain the correct assessment of neuromuscular blockade, muscle relaxants will be given intravenously at dorsi hand with forearm pneumatic tourniquet.
Action Potentials
;
Adult
;
Arm*
;
Depression
;
Forearm
;
Hand
;
Humans
;
Neuromuscular Blockade
;
Succinylcholine
;
Tourniquets
;
Ulnar Nerve
;
Upper Extremity
;
Vecuronium Bromide
4.Benefits of Bilateral Isolated Forearm Techinique to study the neuromuscular blockade.
Sung Yell KIM ; Kyung Ho HWANG ; Si Young OK ; Soon Im KIM ; Kee Ryang AHN ; Sun Chong KIM ; Wook PARK
Korean Journal of Anesthesiology 1994;27(3):246-250
This technique in the conscious volunteers to study the neuromuscular blockade was described in which two different muscle relaxants of ED95X10(-1) in 20ml 0.9% saline were injected simultaneously into one arm and the contralateral arm below the occlusion site of circulation with tourniquet, and then two different neuromuscular blockades were compared following tourniquet released after 80% twitch depression. The benefits of this technique were obtained as following; 1) Simplicity, saving and safety from easily to set up and using low dose of muscle relaxant. 2) Expected results from pure effects of muscle relaxant without any drug interactions. 3) Time shortening of experimental study. 4) Saving time and experiments from simultaneously comparison of control with study group in one experiment. 5) The study of pure receptor binding with muscle relaxant, since a presumed plasma concentration of muscle relaxants is near or actually zero after release of the tourniquet when fresh blood had flushed the limb. Conclusively bilateral isolated forearm technique is elegant method to study the biophase binding interacted of relaxants and cholinerceptor.
Arm
;
Depression
;
Drug Interactions
;
Extremities
;
Forearm*
;
Neuromuscular Blockade*
;
Neuromuscular Blocking Agents
;
Plasma
;
Tourniquets
;
Volunteers
5.A Case Of Rheumatoid Arthritis Accompanied By Severe Eosinophilia.
Chong Il SOHN ; Myeong Kon KIM ; Kee Chang LEE ; Sung Soo JUNG ; In Hong LEE ; Sang Cheol BAE ; Dae Hyun YOO ; Seong Yoon KIM ; Wha Soon CHUNG
The Journal of the Korean Rheumatism Association 1994;1(1):98-102
Eosinophilia is usually accompanied by parasite infestation, allergic condition, drug, collagen disease, and idiopathic hypereosinophilic syndrome. In about 10 to 40% of rheumatoid arthritis patients, peripheral blood reveals eosinophilia. Of the rheumatic disease, eosinophilia may occur in rheumatoid arthritis, sarcoidosis, polyarteritis nodosa and other vascultis. Patient with eosinophilia must be carefully followed up due to possibility of progression to eosinophilic leukemia or myeloproliferatire disease. We experienced a case of rheumatoid arthritis with severe eosinophilia for a period of more than one year in a 53 year-old female patient, eosinophil more than 85% in the peripheral blood, but in spite of careful laboratory study, there was no evidence of parasite infestation, allergic disease and malignant condition that may cause eosinophilia. Therefore we concluded that her severe eosinophilia was associated with rheumatoid arthritis itself, and now she is intensively followed up at the outpatient department. We have to look for any malignant transformation during her clinical course. Marked eosinophilia associated with rheumatoid arthritis is very rare, so we report this case with a review of literatures.
Arthritis, Rheumatoid*
;
Collagen Diseases
;
Eosinophilia*
;
Eosinophils
;
Female
;
Humans
;
Hypereosinophilic Syndrome
;
Middle Aged
;
Outpatients
;
Parasites
;
Polyarteritis Nodosa
;
Rheumatic Diseases
;
Sarcoidosis
6.Surfactant replacement therapy in neonates with respiratory distress syndrome: A collective evaluation of trials from 16 hospitals.
Chong Woo BAE ; Young Dae KWON ; Se Joong KO ; Kee Soo KIM ; Hang Mi KIM ; Won Soon PARK ; Sang Hyun BYUN ; Chang Sung SON ; Ho Sik AHN ; Sang Geel LEE ; Young Pyo CHANG ; Yoon Joo CHUNG
Journal of the Korean Pediatric Society 1993;36(2):244-265
Surfactant replacement therapy in neonates with respiratory distress syndrome (RDS) has been introduced in our country since May 1990. The purpose of this study was to assess the effect and short-term outcome of surfactant replacement for neonatal RDS using collective data of uncontrolled trials from different hospitals in Korea. For the period May 1990 to Dec. 1991, a total of 68 RDS neonates were treated with a reconstituted bovine surfactant (Surfactant-TA) at 17 hospitals. Data on 60 neonates were collected from 16 hospitals and were analyzed in this study. In order to examine the factors that might influence the mortality, we performed a stepwise discriminant analysis. RDS was diagnosed according to accepted clinical and radiographic criteria at each hospital. The mean gestational age of 60 neonates was 31+/-3 weeks (1 SD, range, 24~40 wk) and the mean birth weight was 1549+/-566 grams (range, 590~3300 gm). Surfactant treatment resulted in a significant improvement in ventilatory requirement during the subsequent clinical course. However, there were large variations in the instillation procedure (single vs repeated instillations), dose of surfactant, and respirator settings after surfactant treatment. The neonatal mortality was 40% in this group. When the effect of surfactant treatment was compared between survival and death group, the magnitude of improvement was significantly less in death group than that in survival group. Factors affecting the neonatal mortality include a poor response to surfactant, sepsis and/or DIC, decreasing gestational age and weight, acidosis before treatment and air-leaks. We conclude that treatment with Surfactant-TA has an impact on the clinical course of RDS. To optimize the effects of surfactant therapy, the following refinement will be needed: better initial stabilization with respect to blood pressure, blood gases and pH, instillation techniquse including pre-and post-surfactant ventilation, weaning guidelines, dose, dose schedule, as well as timing of treatment, management of infection, and prevention of severe birth asphyxia.
Acidosis
;
Appointments and Schedules
;
Asphyxia
;
Birth Weight
;
Blood Pressure
;
Dacarbazine
;
Gases
;
Gestational Age
;
Humans
;
Hydrogen-Ion Concentration
;
Infant
;
Infant Mortality
;
Infant, Newborn*
;
Korea
;
Mortality
;
Parturition
;
Sepsis
;
Ventilation
;
Ventilators, Mechanical
;
Weaning
7.In Vitro Amphotericin B Susceptibility of Korean Bloodstream Yeast Isolates Assessed by the CLSI Broth Microdilution Method, Etest, and Minimum Fungicidal Concentration Test.
Ji Young PARK ; Jong Hee SHIN ; Young UH ; Eui Chong KIM ; Seung Jung KEE ; Soo Hyun KIM ; Myung Geun SHIN ; Soon Pal SUH ; Dong Wook RYANG
The Korean Journal of Laboratory Medicine 2008;28(5):346-352
BACKGROUND: Although amphotericin B (AMB) has a wide spectrum of activity that encompasses the majority of yeast isolates, there have been recent reports suggesting that some yeast isolates exhibit decreased susceptibility to AMB. However, in vitro AMB susceptibility of yeast species isolates from blood cultures in Korea has not been fully surveyed. METHODS: A total of 92 bloodstream yeast isolates from four Korean hospitals, representing 10 Candida species (69 isolates) and 4 non-Candida yeast species (23 isolates) were evaluated. AMB minimum inhibitory concentrations (MICs) were determined by two methods: the CLSI method and Etest. AMB minimum fungicidal concentrations (MFCs) were also determined. RESULTS: For all 92 yeast isolates, the CLSI method generated a restricted range of MICs (0.125 to 4 microgram/mL) with 3.3% exhibiting MICs > or =2 microgram/mL, and the corresponding MFC values ranged from 0.25 to 8 microgram/mL with 26.1% showing MFCs > or =2 microgram/mL. Etest produced the widest distribution of MICs, ranging from 0.03 to 32 microgram/mL. High AMB MICs (> or =0.38 microgram/mL) by Etest was observed in 34.8% of the isolates: Candida krusei (100%), Candida rugosa (100%), Trichosporon asashii (100%), Candida glabrata (82%), and Yarrowia lipolytica (75%). Etest disclosed that all isolates of Candida guilliermondii, Candida lusitaniae, Candida pelliculosa and Kodamaea ohmeri were highly susceptible to AMB (MIC < or =0.19 microgram/mL). CONCLUSIONS: Our study showed that Etest may be more useful to discriminate yeast isolates with reduced susceptibility to AMB, and some isolates of less common yeast species from Korea may have decreased AMB susceptibilities.
Amphotericin B/*pharmacology
;
Antifungal Agents/*pharmacology
;
Candida/drug effects/isolation & purification
;
Candidiasis/microbiology
;
Culture Media
;
Humans
;
Korea
;
Microbial Sensitivity Tests
;
Reagent Kits, Diagnostic
;
Yeasts/*drug effects/isolation & purification
8.A Case Report of Autoimmune Hepatitis Associated with Choledochal Cyst and Pancreatitis.
Kyung Ran PARK ; Sun Young LEE ; Soon Young KIM ; Hyoung Shim CHANG ; Nam Sun BACK ; Chong Jai KIM ; Joong Gon KIM ; Jeong Kee SEO
Journal of the Korean Pediatric Society 1996;39(8):1146-1150
Autoimmune hepatitis in children is a rare and severe inflammatory disease of unknown etiology, and progress to cirrohosis and liver failure, generally is responsive to immunosuppressive therapy. It is more prevalent in women than men, and characterized by the presence of circulating autoantibodies, a high serum globulin. Extrahepatic manifestations such as thyroiditis, ulcerative colitis, glomerulonephritis and autoimmune hemolytic anemia, are associated. We report, to our knowledge, the first case of autoimmune hepatitis in conjunction with choledochal cyst and pancreatitis in 11-year-old female patient. At the time of diagnosis, she suffered from acute upper abdominal pain, jaundice, and pallor. Laboratory findings showed Cooms positive hemolytic anemia, hypergammaglobulinemia, hyperbilirubinemia, and high serum transaminases. Antinuclear antibody was of homogeneous type. In liver biopsy, cellular infiltrates largely lymphocytes were noted. Treatment with corticosteroids induced clinical, biochemical remission, but subsequent withdrawal leaded to relapse. Incidentally choledochal cyst were found and then acute pancreatitis developed. After management for acute pancreatitis, surgical resection of cyst with hepatojejunostomy was performed.
Abdominal Pain
;
Adrenal Cortex Hormones
;
Anemia, Hemolytic
;
Anemia, Hemolytic, Autoimmune
;
Antibodies, Antinuclear
;
Autoantibodies
;
Biopsy
;
Child
;
Choledochal Cyst*
;
Colitis, Ulcerative
;
Diagnosis
;
Female
;
Glomerulonephritis
;
Hepatitis, Autoimmune*
;
Humans
;
Hyperbilirubinemia
;
Hypergammaglobulinemia
;
Jaundice
;
Liver
;
Liver Failure
;
Lymphocytes
;
Male
;
Pallor
;
Pancreatitis*
;
Recurrence
;
Thyroid Gland
;
Thyroiditis
;
Transaminases
9.Chorea in Sporadic Creutzfeldt-Jakob Disease
Ai Huey TAN ; Tsun Haw TOH ; Soon Chai LOW ; Si Lei FONG ; Kah Kian CHONG ; Kee Wei LEE ; Khean Jin GOH ; Shen Yang LIM
Journal of Movement Disorders 2018;11(3):149-151
No abstract available.
Chorea
;
Creutzfeldt-Jakob Syndrome
10.Efficacy of Tacrolimus in Primary Kidney Transplant Patients: Multi-center, Open-label, Prospective Study.
Kiil PARK ; Chong Myung KANG ; Yong Bok KOH ; Jin Young KWAK ; Oh Jung KWON ; Sang Joon KIM ; Soon Il KIM ; Yong Soo KIM ; Yu Seun KIM ; In Sung MOON ; Jang Il MOON ; Byung Kee BANG ; Curie AHN
The Journal of the Korean Society for Transplantation 1999;13(2):195-202
Introduction of tacrolimus has been accepted as one of the major advance in the management of rejection following solid organ transplantation. This open-label, multi-center study is designed to confirm the efficacy of tacrolimus in primary kidney transplantation. A total of 64 renal transplant recipients were recruited from 4 medical centers, and received dual drug therapy consists of tacrolimus and low-dose corticosteroids after kidney transplantation. Tacrolimus was started 2 days prior to the transplantation with the dosage of 0.2 mg/kg/day. Daily dose of tacrolimus was modulated to maintain the trough blood level between 15 ng/ml and 20 ng/ml for the first 3 months and between 10 ng/ml and 15 ng/ml for the next 3 months after the transplantation. Steroid pulse therapy with methylprednisolone was used as a first line modality of acute rejection treatment. Steroid resistant rejection was treated with anti- lymphocyte agents. Post-transplant diabetes mellitus was defined as the cases when patients who had no history of glucose intolerance need the use of oral hypoglycemics and/or insulin for 30 days or longer to control their hyperglycemia after transplantation. There were 51 live donor and 13 cadaveric donor transplantations. Live donor transplantation consisted with 33 related (10 HLA identical, 23 HLA haplo- identical) and 18 unrelated pairs. Mean age of the patients was 39.4 9.6 (range; 22-58). There were 36 male and 28 female patients. There were 21 acute rejection episodes in 17 patients (26.6%) during the first 6 months after transplantation. Six patients were treated with anti-lymphocyte agents, and 4 patients showed complete response but 2 episodes (9.5%) showed partial rescue. Six-month patient and graft survivals were 100% and 98.4%, respectively. A total of 18 patients (28.1%) experienced glucose intolerance during the study period. Tacrolimus showed satisfactory efficacy in primary kidney transplantation. Long-term follow up is needed for further evaluation of efficacy and safety.
Adrenal Cortex Hormones
;
Cadaver
;
Diabetes Mellitus
;
Drug Therapy
;
Female
;
Follow-Up Studies
;
Glucose Intolerance
;
Graft Survival
;
Humans
;
Hyperglycemia
;
Hypoglycemic Agents
;
Insulin
;
Kidney Transplantation
;
Kidney*
;
Lymphocytes
;
Male
;
Methylprednisolone
;
Organ Transplantation
;
Prospective Studies*
;
Tacrolimus*
;
Tissue Donors
;
Transplantation
;
Transplants