Ultraviolet radiation of skin leads to a systemic alteratior tkat inhibits the normal pattern of immunologic tumor rejection., suppresses the contact hypersemisivity and transiently alters the morphology and the surface marker characteristics of Langerhans cells. Moreover, Ultraviolet radiation elaborates the ETAF, neuropeptides, proteins, and urocaicacid which may alter immunologic responses. But no other study about the effects of UVB irradiation on the systemic immunologic functions of the macrophages of internal organs was reported. The macrophages of the reticuloendothelial system (RES) play a central role in cell-mediated immunity, because they are involved both in the initiation of responses as antigen-presenting, cells, and in the effector phase as inflammatory, tumoricidal and microbicidal cells. The present study was intended to investigate the effects of UVB irradiation on the immunologic functions of mouse peritoneal macrophages. Normal 6-8-week-old BALB/c mice were exposed at the dose rate of 20mJ/cm and 40mJ/cm of UVB per day, 5 days per weeks for 2 weeks, 4 weeks and 8 weeks. Then the peritoneal macrophages were obtained from the mice and the changes of cell count, chemotactic index, phagocytic index, NBT reduction rate and superoxide (0) production were examined. The results were as follows : 1)the number of mouse peritoneal macrophages was decreased by UVB radiation, 2) the chemotactic index of mouse peritoneal macrophage was not altered by UVB radiation, 3) phagocytic activity of mouse pertoneal macrophage was significsntly decreased by UBV radiation, 4) NBT reduction rate in mouse aeritoneal macrophage after UVB radiation was sinificanily decreased in all experimental group, and 5) Superoxide (0) production in mouse peritoneal macrophage after UVB radiation was decreased in all experimental groups.
Animals ; Cell Count ; Immunity, Cellular ; Langerhans Cells ; Macrophages ; Macrophages, Peritoneal* ; Mice* ; Mononuclear Phagocyte System ; Neuropeptides ; Skin ; Superoxides

Forty one cases of patella fractures which were treated at the Department of Orthopaedic Surgery, Catholic Medical College during the period from January 1971 to March 1974 were presented. Most fractures encountered in man of 3rd and 4th decades, sixty percent of fracture was in the mid-pole of patella and thirty percent in the lower pole. Twenty nine(29%) fracture was induced by direct blow and remainders by indirect violence. When the knee joint was immobilized in 15 flexion with crlinder cast in certain period of time, early joint mobility was restored after the discontinuence of the cast. The tibial tubercle-plasty in association with fracture reduction to increase quadriceps power and to prevent late occureace of patellofemoral arthritis gave satisfactory result in two cases.
Arthritis ; Joints ; Knee Joint ; Patella ; Violence

Nowadays the clinical impression in Korea is that genu varum uncommon though there was high incidence of this deformity by vitamin D deficiency in the early 1900. Authors reviewed the case histories and x-ray of 18 patients treated for this condition at the Dept. of Orthopaedics, St. Mary's hospital for past 5 years: 17 patients were under 5 years of age. 12 patients had rachitic bowIeg and among them four had active ricket. Six patients had physiologic bowleg deformity. Classification in four grades according to severity of bowleg is attempted. Among the cases eleven patients having less than 10 degree of bowleg treated conservatively with good end result, but corrective osteotomy is routinely scheduled for seven patients having bowleg of knee over 10 degree and resist to treatment. Lasting it is stressed that physiologic bowleg shoud be distinguished from pathologic one. Diagnosis of bow leg can not be made before age of 2–3 years, that is, before transitional phase of development of knee angle.
Classification ; Congenital Abnormalities ; Diagnosis ; Genu Varum ; Humans ; Incidence ; Knee ; Korea ; Osteotomy ; Vitamin D Deficiency

No abstract available.
Animals ; Blastocyst* ; Embryonic Structures* ; Mice*

Although recently, there have been introduced many new diagnostic tools such as renal scanning and renogram, intravenous urogram remains to be one of the most useful method of urological diagnosis. Therefore it seems warranted to review 363 cases of intravenous urograms performed in the department of urology, St. Mary's hospital, Catholic Medical College during the period of January, 1962 to June, 1964. Among others, especial attention was paid to 60 cases of nonvisualizing kidneys. Of 60 nonvisualizing kidneys, renal tuberculosis occupied 27 cases(45%); ureteral and renal stones 13(21.6%); hydronephrosis 9(15%) (metastatic carcinoma 6(10%)and surgical manipulation 3(5%); Wilms' tumor 5 (8.3%) chronic atrophic pyelonephritis 3(5%) ; One case each of renal cell carcinoma, cystic kidney and thrombosis of the renal artery. Inasmuch as the present study revealed renal tuberculosis to be the most common cause of nonvisualizing kidneys, it is felt that one should always consider the possibility of tuberculosis in the diagnosis of nonvisualizing kidneys in Korea. This fact should be stressed because nontuberculous pathology such as chronic pyelonephritis has been implicated to be the most frequent cause of nonvisualizing kidneys by American authors.
Carcinoma, Renal Cell ; Diagnosis ; Hydronephrosis ; Kidney Diseases, Cystic ; Kidney* ; Korea ; Pathology ; Pyelonephritis ; Radiography* ; Renal Artery ; Thrombosis ; Tuberculosis ; Tuberculosis, Renal ; Ureter ; Urology ; Wilms Tumor

With the improvement of economic conditions and medical care, the average life span has increased, thus making geriatrics an important consideration in the medical field. Degenerative changes of the cervical spine in aged are not uncommon. Also it is well known tha subjects with radiologic features of cervical spondylosis may be symptom free. On the other hand, cervical myelopathy may occur in the presence of minimal spondylosis as shown radiologically. This discrepancy between symptoms and radiologic features seems to be attributed to the differences in the initial structure of the cervical spine. The authors surveyed at random the various radiographic measurements of 300 Koreans having normal cervical spines and 120 Koreans with cervical spondylosis. The results of the survey are as follows: 1. Osteophyte was noticed more frequently at the 3 rd, 4 th and 5 th cervical vertebrae. 2. Lordosis angle was greater in spondylosis group than in normal group, which might be attributed to paravertebral muscle spasm. 3. Normal sagittal diameter of the canal decreased between C3-C6 and the narrowest was at C4 level. The sagittal diameter, on the average, was 1.5 mm shorter than in European population and 1 mm longer than Japanese. This might be attributed to the difference in the body height. 4. In the normal spine group the average interpedicular distance was greatest at the 5 th, and 6 th cervical vertebra. In the cervical spondylosis group the average interpedicular distance was greater than in normal population it was greatest at the 5 th and 6 th cervical vertebra.
Animals ; Asian Continental Ancestry Group ; Body Height ; Cervical Vertebrae ; Female ; Geriatrics ; Hand ; Humans ; Lordosis ; Osteophyte ; Spasm ; Spinal Cord Diseases ; Spine ; Spondylosis

The bcl-2 oncoprotein confers a survival advantage to cells by blocking programmed cell death. Overexpression of bcl-2 probably plays a role in tumorigenesis, and the expression of the bcl-2 protein has been investigated in many kinds of tumors. However, there have been only a few reports on expression of bcl-2 in human gastric adenocarcinoma. The aim of this study was to investigate the relationship between the expression of bcl-2 protein and several clinical and pathological parameters such as age, tumor site, size, histological type, depth of invasion, Lauren's classification, and grade. Immunohistochemical staining using monoclonal bcl-2 protein antibody, clone 124, was performed on paraffin embedded specimens from 23 gastric adenomas and from 45 gastric adenocarcinomas. The results are as follows. 1. Variable intensity of epithelial staining was noted from case to case, although the lymphocytic component showed similar intensity in all examples. The staining was located at the gland and mucous neck region of non-neoplastic epithelium. 2. The more differentiated type of gastric adenocarcinoma showed the higher expression rate and intensity. 3. The relationship between the expression rates of bcl-2 protein and tumor grade (adenoma early gastric adenocarcinoma advanced gastric adenocarcinoma) was statistically significant. The reactivity in adenoma was somewhat stronger with a uniform pattern, while in adenocarcinoma it was much weaker with a heterogenous pattern. 4. Intestinal type carcinomas by Lauren's criteria showed a higher expression rate and intensity than diffuse type. These results suggest that the bcl-2 expression would be found in the early phase of gastric tumorigenesis, and the expression rate and intensity would decrease according to the tumor progression.
Adenocarcinoma* ; Adenoma* ; Carcinogenesis ; Cell Death ; Classification ; Clone Cells ; Epithelium ; Humans ; Neck ; Paraffin

BACKGROUND: Previous studies have shown that in vitro exposure to ultraviolet B(UVB) radiation resulted in a dose-dependent inhibition of natural killer activity(NK activity) of normal human peripheral blood mononuclear cella(PBMC), and that in vivo exposure to snlight also induced NK activity suppression. The precise meehanism of the UV-regulation on the riat iral killer system(NK system) is not established. Objective & METHOD: The purpose of this study is to examine whether the addition of interleukin-2(IL-2) and/or free oxygen radical scavengers, superoxide dismutas(SOD) or sodium azide(SA), is effective in reducing the UVJ3-induced suppression of NK activity of FBMC. RESULTS: The results are as follows 1. The suppressive effect of UVB radiat,ion on NK activity could successfully be prevented in the presence of SOD(100 and 1,000U/ml) during the radiation. 2. SA( LO and 10 M/ml) did not prevent the suppression of NK activity. 3. IL-2(100U/ml) markedly enhanced the NK activity of nonirradiated PBMC, but had no effect on irradiated PBMC. 4. Combination treatment with both IL-2 and free radical scavengers on UVB-irradiated PBMC resulted in no additive or synergistic effect on the prevention of the suppression of NK activity compared with a single treatment with either IL-2 or free radical scavengers. CONCLUSION: In the presserit study, we found that SOD providec a protective effect on NK activity during the UVB radiation and we suggest that superoxide anion(O ) might play a major role in the UV-regulatory mechanisms of the NK system.
Free Radical Scavengers ; Humans* ; Interleukin-2* ; Oxygen ; Sodium ; Superoxides

BACKGROUND: Topical 1% butenafine hydrochloride cream, a new benzylamine derivative, has been reported to have antimycotic effect. OBJECTIVE: An open trial as conducted to assess the efficacy and safety of 1% butenafine hydrochloride cream used once daily in the treatment of tinea pecis. METHODS: Of 45 patients with clinically and mycologically proertinea pedis from the department of dermatology at Kosin medical college hospital, 42 patient, who could be monitored to the end of this study were evaluated. They applied 1% butenafine hydrochloride cream once daily until clinical improvement became evident or for 4 weeks and the effects were evaluated clinically and mycologically. RESULTS: 1. From the mycological studies at the initial visit, causative organisms were isolated from 36 patients out of the 42 subjects and Trichophyton rubrum was most comnmon organism. 2. The negative conversion rate of the mycological study( negative microscopy and negative culture) was 90.5%(38/42) after 4 weeks of treatment. 3. The effective treatment vate at 4 weeks was 90.5%(38/42) 4. A adverse effects of using 1% butenafine hydrochloride cream was noted in 1 patient, who had a moderate degree of puritus, out of the 42 subjects. The presritus disappeared soon after the cessation of application of the cream. CONCLUSION: 1% butenafine lydrochloride cream is effective andafe in the treatment of tinea pedis.
Dermatology ; Humans ; Microscopy ; Tinea Pedis* ; Tinea* ; Trichophyton

Wilson disease gene (WND) locus is presumed to be located in chromosome 13q. There are studies on the clinical heterogeneities and variations between ethnic groups in Europe, North America, and the Middle East and it requires the study of another ethnic group, especially Asian population for the confirmation. This study was an anlysis of restriction fragment length polymorphism of the Wilson's disease with the probes on D13S26, D13S31, and D13S59, The subject was 34 persons of seven families. The serum ceruloplasmin and the serum copper were also measured. The results were as follows: 1) The Wilson disease gene was also presumed to be located in chromosome 13q area in Korean patients and D13S25, D13S26, D13S31 and D13S59 gene loci were also linked to Wilson disease of Koreans. The lod score of D13S25 was 1.45 (theta =0: D13S59, 1.13 (theta =0): D13S26, 247 (theta =0). 2) Three siblings of Wilson disease patients were diagnosed as carriers by the analysis of restriction fragment length polymorphism. 3) In Wilson disease patients, the serum ceruloplasmin and copper was 6.8+/1.8dl, and 64.7+/-38.6microg/dl respectively and it is 18.8+/-6.1 mg/dl and 65.3+/-10.6microg/dl respectively in heterozygotes.
Asian Continental Ancestry Group ; Ceruloplasmin ; Copper ; Ethnic Groups ; Europe ; Genetic Linkage* ; Hepatolenticular Degeneration* ; Heterozygote ; Humans ; Lod Score ; Middle East ; North America ; Polymorphism, Restriction Fragment Length ; Siblings