No abstract available.
Humans ; Siblings* ; Vesico-Ureteral Reflux*

To evaluate the diagnostic findings of salivary gland tumors, we reexamined aspiration cytology smears of 7 cases of pleomorphic adenoma, 3 cases of adenoid cystic carcinoma, and 3 cases of mucoepidermoid carcinoma, performed during April 1986 to March 1990, which were com?med by surgical excision and histologic diagnosis. The results obtained are summarized as follows ; 1. All cases of pleomorphic adenoma showed branching cellular clusters of epithelial and myoepithelial cells. Acellular elements including myxomatous and chondroid components were observed. There were no cellular pleomorphism and nucleoli. Keratinizing squamous epithelial cells and keratin pearls were noted. 2. The smears of adenoid cystic carcinoma showed cell balls or cell cords containing a central hyaline core. Nuclear atypism and the nucleoli were frequently observed. There were no keratinizing squamous epithelial cells. 3. The smears of mucoepidermoid carcinoma showed mainly sheets or clusters of intermediate cells and some mucin-producing cells. Some nuclear pleomorphism was observed. Mucinous material and many inflammatory cells were present in the background.
Adenoma, Pleomorphic ; Breast Neoplasms ; Carcinoma, Adenoid Cystic ; Carcinoma, Mucoepidermoid ; Diagnosis ; Epithelial Cells ; Hyalin ; Mucins ; Salivary Glands ; Vesico-Ureteral Reflux*

Angiotensin II plays an important role in the regulation of systemic and renal hemodynamics, and functions as a growth factor in various tissues. To determine whether ANG II are related to renal-specific stimulation of apoptosis, 36 adult male Sprague-Dawley rats were infused with ANG II at 50 ng/min(low ANG group), 100 ng/min(high ANG group), or vehicle(control group) for 1 week using osmotic minipump(Model 1007D, Alza Co, USA) inserted into the interscapular area of the back. Blood pressure and serum aldosterone level were measured. To detect apoptosis of the kidney, TUNEL(Terminal deoxynucleotidyl Transferase dUTP Nick End Labelling) technique was introduced. Cellular proliferation was detected with PCNA immune histochemical staining. To know the expression of Bcl-2 protein and mRNA, immune histochemical staining, Western blot assay and RT-PCR were done. Results were as follows: 1) There were no differences in body weight or organ weight/body weight among 3 groups. 2) Mean blood pressure between control and low ANG group were not changed throughtout the study. But mean blood pressure was increased at th day 3 and 7 in high ANG group(P<0.05). Serum aldosterone level increased at the day 7 in high ANG group only(P<0.05). 3) PCNA positive cells were increased significantly in the the low ANG groups compared with the control group(P<0.05) and they were decreased significantly in the .high ANG group compared with the the low ANG group(P<0.05). However, they were not different between control and high ANG groups. 4) Apoptosis of renal medulla was increased significantly in the low and high ANG groups compared with the control group(P<0.05). 5) Expression of bcl-2 protein was decreased significantly in the low and high ANG groups compared with the control group(P<0.05). In this study, ANG II infusion induced renal apoptosis and changed expression of PCNA but decreased expression of bcl-2 in the kidney of the Sprague-Dawley rat. In conclusion, histologic changes of the kidney may be controlled by ANG II regardless of systemic hypertension.
Adult ; Aldosterone ; Angiotensin II* ; Angiotensins* ; Animals ; Apoptosis* ; Blood Pressure ; Blotting, Western ; Body Weight ; Cell Proliferation ; DNA Nucleotidylexotransferase ; Hemodynamics ; Humans ; Hypertension ; Kidney ; Male ; Proliferating Cell Nuclear Antigen ; Rats ; Rats, Sprague-Dawley ; RNA, Messenger

No abstract available.
Aged* ; Humans ; Nursing Homes* ; Nursing*

To determine the types of metabolic a cidosis using anion gap in acute infantile diarrhea and to correlate it with clinical outcome, we examined 103 infants admitted with acute diarrhea. The serum electrolytes (sodium, potassium, chloride, phosphorus), creatinine, CO2 content and anion gap were measued on first admission day. They were classified group A with normal anion gap (8~16mEq/L) and group B with increased anion gap (>16mEq/L). The results were as follows. 1) The number of group A with normal anion gap (11.6+/-3.3mEq/L) was 62 and the number of group B with incresed anion gap(21.1+/-5.5mEq/L) was 38. 2) The duration of diarrhea was significantly prolonged in group B (9.0+/-2.5 days), compared with group A (5.9+/-1.1 days)(p<0.001). 3) The duration of admission was significantly prolonged in group B(5.6+/-2.2 days), compared with group A (4.+/-01.4days)(p<0.001). 4) Infants in group B, compared with group A, were significantly more severe dehydrated (p.
Acid-Base Equilibrium ; Acidosis* ; Creatinine ; Diarrhea ; Diarrhea, Infantile* ; Electrolytes ; Humans ; Infant ; Potassium

No abstract available.
Nephrotic Syndrome* ; T-Lymphocyte Subsets* ; T-Lymphocytes*

The uterine cervix is an uncommon site of primary non-Hodgkin's lymphoma (NHL). Although the cytologic findings of NHLs are well known, most cervicovaginal smear of uterine NHLs give lower diagnostic yield than common epithelial malignancy because abnormal cells do not appear in the sample in the absence of surface ulceration. Herein, we describe cytologic findings of a case of uterine cervical NHL which was initially diagnosed by cervicovaginal smear. The tumor cells were relatively uniform, isolated, large-sized with scanty cytoplasm and round or indented nuclei. The nuclei had stippled chromatin and small nucleoli. Histologically and immunohistochemically the tumor was proven to be large cell lymphoma of T-cell lineage.
Buttocks ; Cervix Uteri ; Chromatin ; Cytoplasm ; Epidermal Cyst ; Female ; Lymphoma ; Lymphoma, Non-Hodgkin ; Nephrotic Syndrome* ; T-Lymphocytes ; Ulcer

In 1930s, Mauriac described a syndrome in diabetic children consisting of stunted growth, hepatomegaly, and delayed puberty. This syndrome was related to poorly controlled diabetes of long duration. A 14-year-old girl, who had been diagnosed as insulin dependent diabetes mellitus three years ago but had not been well controlled for diabetes, visited to hospital because of short stature, delayed puberty, and visual disturbance. On physical exam her height was 146cm(<3 percentile) and her weight was 34kg(<3 percentile) and sexual maturation was delayed as Tanner stage I. The liver was 3FB palpable below the right subcostal margin. She had hyperglycemia and elevated plasma cortisol. She was diagnosed as Mauriac syndrome. On ophthalmologic examination, the cataracts were observed on both eyes and she had also peripheral neuropathy on lower extremities. Her blood glucose was controlled strictly by regular insulin during admission, and her weight was increased and hepatomegaly was improved at discharge, two months later. We report a case of Mauriac syndrome with a brief review and related literatures.
Adolescent ; Blood Glucose ; Cataract ; Child ; Diabetes Mellitus ; Female ; Hepatomegaly ; Humans ; Hydrocortisone ; Hyperglycemia ; Insulin ; Liver ; Lower Extremity ; Peripheral Nervous System Diseases ; Plasma ; Puberty, Delayed ; Sexual Maturation

No abstract available.
Mediastinal Emphysema*

The kidneys play a fundamental role in the long-term control of arterial pressure by regulating sodium balance and extracellular fluid volume. The renin-angiotensin system (RAS) is at the center of the regulation of hypertension and progressive renal injury. It has gradually become clear that not only systemic RAS, but also intrarenal RAS has specific effects in the pathogenesis and progression of hypertension and renal damage. All of the RAS components are exhibited in the kidney and intrarenal angiotensin II (Ang II) is formed by multiple mechanisms. The demonstration of much enhanced levels of Ang II within specific renal compartments points out selective local regulation of Ang II in the kidney, showing that intrarenal Ang II levels are regulated in a way different from circulating Ang II. The importance of the RAS in involving proper nephrogenesis is also well known, and suppression of the RAS during fetal development may play a key role in mediating the structural and physiological changes observed in models of fetal programming of hypertension.
Angiotensin II ; Arterial Pressure ; Blood Pressure ; Extracellular Fluid ; Fetal Development ; Hypertension ; Kidney ; Negotiating ; Renin-Angiotensin System ; Sodium