The authors observed one case of typical Kaposi's sarcoma who was 24 year old male. This patient complained of dark-brownish pigmented macules and oozing ulcer on the right knee joint area since at birth and the lesions were slowly growing and increased the number with pain. The skin lesions revealed 3*2.5cm sized dark-brownish colored macuIe, 2.5*3*1cm sized blood discharged nodule and 1* 1cm to l. 5* l. 5cm sized dark-brownish atrophic macules on the right inguinal area.Histopathologically, a biopsy was done on the right knee joint area, the finding showed angiomatous and fibrotic nature, I.e. the blood vessels in the dermis were dilated and increased in number. The endothelial cell was large and protrude into the lumen and showed small group of extravasated erythrocytes in granulation tissue, and showed extensive proliferation of spindle shaped cells that extended irregularly into various direction.
Biopsy ; Blood Vessels ; Dermis ; Endothelial Cells ; Erythrocytes ; Granulation Tissue ; Humans ; Knee Joint ; Male ; Parturition ; Sarcoma, Kaposi* ; Skin ; Ulcer ; Young Adult

Speckled lentiginous nevus is a clinical variant of nevus-cell nevus first described by Stewart et al. in 1978. It is characterized by small, dark hyperpigmentated speckles superimposed on a tannish-brown background. The speckled areas show varying histologic patterns ranging from nevus incipiens to junctional or compound nevus. The back ground shows histologic features of Ientigo simplex. Recently, we observed clinical and histological features of 5 cases of speckled lentiginous nevi. The age of onset ranges from birth to infancy, The locations are face, thigh, back and scapula. One has zosteriform distribution in upper extrernity, chest and back. Histologic features of speckles are junctional or compound nevus. We suggest that the origin of dark speckles may be from the tannish-brown background, lentigo simplex.
Age of Onset ; Lentigo ; Nevus* ; Parturition ; Scapula ; Thigh ; Thorax

Pseudoxanthoma. elasticum is a rare, heritable, systemic disease of connective tissue characterized by degeneration of elastic tissue and mainly affecting the skin, eyes and blood vessels. Recently, according to Pope (1974), it can be inherited as an autosomal dominant or recessive trait. We presented a study of 5 cases of pseudoxanthoma elasticum of autosomal recessive inheritance, which showed typical peau d'orange skin lesions. Two among the 5 cases were associated with angioid streaks, a case with myopia and broderline mental retardation, and 2 cases without any other systemic disturbances.
Angioid Streaks ; Blood Vessels ; Connective Tissue ; Drug-Induced Liver Injury* ; Elastic Tissue ; Intellectual Disability ; Myopia ; Pseudoxanthoma Elasticum ; Skin ; Stevens-Johnson Syndrome* ; Wills

Pseudoxanthoma. elasticum is a rare, heritable, systemic disease of connective tissue characterized by degeneration of elastic tissue and mainly affecting the skin, eyes and blood vessels. Recently, according to Pope (1974), it can be inherited as an autosomal dominant or recessive trait. We presented a study of 5 cases of pseudoxanthoma elasticum of autosomal recessive inheritance, which showed typical peau d'orange skin lesions. Two among the 5 cases were associated with angioid streaks, a case with myopia and broderline mental retardation, and 2 cases without any other systemic disturbances.
Angioid Streaks ; Blood Vessels ; Connective Tissue ; Elastic Tissue ; Intellectual Disability ; Myopia ; Pseudoxanthoma Elasticum ; Skin ; Wills

No abstract available.
Blister* ; Nevus* ; Rubber*

No abstract available.
Blister* ; Nevus* ; Rubber*

No abstract available.
Female ; Lymphoma* ; Ovary*

No abstract available.
Liver Transplantation* ; Liver*

Primary gallbladder cancer is a highly malignant tumor and is characterized by early metastasis and rapid progression of disease. Since the majority of patients have unresectable disease, laparotomy, instead of providing relief of symptoms, often adds to the morbidity and needs to be avoided in patients with advanced disease. Clinical features, peritoneoscopic findings, and comparison of peritoneoscopy with radiologic studies were reviewed in 29 patients, who underwent peritoneoscopy, with primary gallbladder cancer at Severaace Hospital, College of Medicine, Yonsei University between Aug. 1982 and Mar. 1994. (continue...)
Gallbladder Neoplasms* ; Gallbladder* ; Humans ; Laparoscopy* ; Laparotomy ; Neoplasm Metastasis

BACKGROUND: Bone marrow mesenchymal stem cells (MSC) inhibit the immune response of lymphocytes to specific antigens and dendritic cells (DC) are professional antigen- presenting cells whose function is to present antigen to naive T-lymphocytes with high efficiency and play a central role in the regulation of immune response. We studied the effects of MSC on DC to evaluate the relationship between MSC and DC in transplantation immunology. METHODS: MSC were expanded from the bone marrow and DC were cultured from peripheral blood mononuclear cells (PBMNC) of 6 myelogenous leukemia after achieving complete response. Responder cells isolated from PBMNC and lysates of autologous leukemic cells are used as tumor antigen. The effect of MSC on the DC was analyzed by immunophenotype properties of DC and by proliferative capacity and the amount of cytokine production with activated PBMNC against the allogeneic lymphocytes. Also, cytotoxicity tests against leukemic cells studied to evaluate the immunologic effect of MSC on the DC. RESULTS: MSC inhibit the CD83 and HLA- class II molecules of antigen-loaded DC. The proliferative capacity and the amount of INF-gamma production of lymphocytes to allogeneic lymphocytes were decreased in DC co-cultured with MSC. Also the cytotoxic activity of lymphocytes against leukemic cells was decreased in DC co-cultured with MSC. CONCLUSION: MSC inhibit the activation and immune response of DC induced by allogeneic or tumor antigen.
Bone Marrow ; Cell Culture Techniques* ; Dendritic Cells* ; Leukemia, Myeloid ; Lymphocytes ; Mesenchymal Stromal Cells* ; T-Lymphocytes ; Transplantation Immunology