Objective To compare the efficacy of sertraline hydrochloride combined with risperidone or quetiapine in the treatment of schizophrenia.Methods Eighty-six patients with schizophrenia in Ningbo Psychiatric Hospital were selected and divided into observation group and control group according to the order of admission.The observation group was treated with sertraline hydrochloride combined with quetiapine , and the control group was treated with sertraline hydrochloride combined with risperidone.The clinical symptoms score,clinical efficacy and adverse reactions were compared between the two groups.Results Before treatment,the negative symptoms,positive symptoms,psychopa-thology,total score between the two groups had no statistically significant differences (all P＞0.05).After treatment, the negative symptoms ,positive symptoms,psychopathology and total scores of the observation group were (13.43 ± 1.27)points,(11.26 ±1.05)points,(13.54 ±1.84)points and(46.48 ±4.52)points,respectively,which were significantly lower than those of the control group[(16.87 ±1.98)points,(15.48 ±1.63)points,(18.35 ±2.04)points, (58.25 ±5.76)points](t＝9.590,14.272,11.481,10.541,all P＜0.05).The total effective rate of the observation group was significantly higher than that of the control group [93.02%(40/43) vs.67.44%(29/43)](χ2＝8.871, P＜0.05).There was no statistically significant difference between the two groups in the incidence rate of adverse reactions (P＞0.05).Conclusion Sertraline hydrochloride combined with quetiapine in the treatment of schizophrenia can improve the clinical symptoms of patients ,the clinical efficacy is good ,with mild adverse reactions.