Objective To evaluate whether eight kinds of dosimeters satisfy the clinical mammography dose measurement through the comparison of energy response.Methods According to GB/T 19629-2005,the energy responses of eight available mammography dosimeters were determined for ten standard radiation qualities in the range 25-40 kVp at the SSDL using a refrence-class dosimeter.Results Except 2000S,the energy response factors of all the other dosimeters were consistent within ±5%.Conclusions The energy response of ionizing chamber type is better than other types of dosimeters.

Objective To fulfill the requirements for uncertainty of the calibration apparatus for dosimeters used in X-ray mammography through setting standard radiation quality at the SSDL and developing calibration procedures.Methods According to IEC 61267-2005 and IAEA TRS No 457 to recommend RQR-M and RQA-M series standard radiation quality,the calibration apparatus was evaluated for long term stability of the radiation field over 8 years from 2006 to 2014,including 10 response quantities,such as field homogeneity,change rate of mean air kerma and scatter radiation contributions and so on.In addition,the reference dose instrument was traced back to the PSDL of PTB in Germany by post during 2008 and 2012.Results The field homogeneity (φ 40 mm) relative error was ± 1.4％.The long term stability of the calibration apparatus was less than ± 2％ (limits of variation).The scatter radiation contributions at their points of test were below 0.12％.The calibration factors traced to PTB were 0.999-1.000.As a result of the calibration apparatus,the expanded uncertainty was ± 3％ (k =2,95％ confidence interval).Conclusions The calibration apparatus may meet the requirements of IEC 61267-2005 and IAEA TRS No 457 and has obtained the license of metrology from national regulatory authority.The laboratory now performs very well to calibrate dosimeters used in X-ray mammography.

Objective To put forward reasonable and feasible recommendations against the procedure with relative high risk during the high dose rate (HDR) afterloading radiotherapy,so as to enhance its clinical application safety,through studying the human reliability in the process of carrying out the HDR afterloading radiotherapy.Methods Basic data were collected by on-site investigation and process analysis as well as expert evaluation.Failure mode,effect and criticality analysis (FMECA) employed to study the human reliability in the execution of HDR afierloading radiotherapy.Results The FMECA model of human reliability for HDR afterloading radiotherapy was established,through which 25 procedures with relative high risk index were found,accounting for 14.1％ of total 177 procedures.Conclusions FMECA method in human reliability study for HDR afterloading radiotherapy is feasible.The countermeasures are put forward to reduce the human error,so as to provide important basis for enhancing clinical application safety of HDR afterloading radiotherapy.

Objective To explore the method for measuring and calculating both absorbed dose and effective dose received in organ and tissues of occupational workers by using TLDs for the implantation of 125Ⅰ seed sources.Methods The experiments with 60Co γ-rays were carried out for the stability.A group of TLD chips was exposed to 125Ⅰ seed sources to establish standard dose curve for air kerma.During the 125Ⅰ seed implantation, the TLD chips were pasted to 13 locations like thyroid inside and outside the lead aprons worn by occupational workers to measure average absorbed dose and calculate the absorbed doses and effectives to organs and tissues.Results For 3 cases of prostate cancers with implantation of 125Ⅰ seeds, the worker's organs and tissues received the absorbed dose 0.02 -3.80 μ Gy and effective dose 0.06- 1.81 μSv outside lead aprons and the highest absorbed dose 2.35 μ Gy and effective 0.02 μSv inside lead aprons, respectively, with more than 65.9% of rays shielded.For 3 cases of brain cancers with implantation of 125Ⅰ seeds, the workers received the absorbed dose 0.23 - 11.31 μGy and effective dose 0.88 - 4.07 μSv outside lead aprons and the highest absorbed dose 2.22 μ Gy and effective dose 0.09 μSv inside lead aprons, respectively, with more than 54.5% of rays shielded.For 3 cases of lung cancers with implantation of 125Ⅰ seeds, the workers received the absorbed dose 0.03 - 14.78 μGy and effective dose 0.35 -7.59 μSv outside lead aprons and the highest absorbed dose 4.09 μGy and effective 0.22 μSv inside lead aprons, respectively, with more than 58.4% of rays shielded.For 2 cases of mediastinum cancers with implantation of 125Ⅰseeds, the workers received the absorbed dose 0.06 - 74.91 μGy and effective dose 0.83 - 17.96 μSv outside lead aprons and the highest absorbed dose 10.29 μGy and effective 0.5 μSv inside lead aprons, respectively, with more than 85% of rays shielded.For one case of ovary cancer with implantation of 125Ⅰ seeds, the worker received the absorbed dose 0.09 - 14.29 μGy and effective dose 2.40 - 4.50 μSv outside lead aprons and the highest absorbed dose 7.77 μGy and effective 0.12 μSv inside lead aprons, respectively, with more than 34% of rays shielded.For one case of eye cancer with implantation of 125Ⅰ seeds, the workers received the absorbed dose 2.2 -39.84 μGy and effective dose 4.48 - 10.06 μSv outside aprons and the highest absorbed dose 5.19 μGy and effective 0.16 μSv inside aprons, respectively, with more than 54.6 % of rays shielded.Conclusions The method of using TLDs to measure the doses to the occupational workers in the course of the implantation of 125Ⅰ seed sources is simple and easy to operate.It would be an effective approach to protecting medical workers in the case of brachytherapy.

Objective To put forward reasonable and feasible recommendations aiming at enhancing the application safety of afterloading unit, through studying the human reliability in the emergency response against the source blockage of afterloading unit.Methods Based on the human cognition reliability model, ten operation errors during the emergency response against the source blockage of afterloading unit were analyzed and permissible time widow of emergency response operation were determined.The human error probability was calculated with the execution time of emergency response operation obtained through simulation, observation and recording.Results The operation action, relevant permissible time window and execution time were obtained with the corresponding human error probabilities in the range 0.04 - 0.27.Conclusions The human error model in emergency response against the source blockage of afterloading unit based on HCRmodel is feasible, and provides important reference basis to reduce the occurrence of potential exposure and mitigate the consequence of potential exposure.

Objective To study the angular dependence of four different mammographic dosimeters to monoenergetic X-ray beams and observe the variation tendency in angular dependence to different energy X-rays and to discuss the evaluation of average glandular dose(AGD)in digital breast tomosynthesis(DBT)system.Methods One ionization chamber and three semiconductor dosimeters were exposed by four kinds of beam quality.The signal of each dosimeter was tested over an angular range of 0° to 90°.The dosimeters were exposed for three times at each selected angular position.The measurement at each angle was normalized to the appropriate measurement at perpendicular incidence.Results The responses from all the dosimeters had a maximum at 0° and decreased with increasing angles.When the radiation incidence angle was 10°,the angular dependence were 0.99,0.99,0.96 and 0.96 for dosimeters A,B,C and D,respectively.And the angular dependence decreased to 0.96,1.00,0.78 and 0.52 when the incidence angle was up to 25°.For semiconductor dosimeters,no signal was recorded when incidence angle was beyond 45°.For ionization chamber,the magnitude of the angular dependence generally decreased with increasing energy.Conclusions All of the dosimeters will underestimate the dose if used in DBT.In order to minimize the error due to the rotation angle of X-ray tube,correction factor of mammography dosimeter should be used for the measurement of AGD in DBT systems.

Objective To study the dosimetric characteristics of two different radiochromic films used to estimate peak skin dose(PSD) of patients.The characteristics of these two films were investigated and compared after exposure to ionizing radiation in the diagnostic energy range,including post-exposure gray growth,sensitivity,energy dependence and dose response.Methods GafChromic XR-RV3 film and KODAK EDR2 film were exposed to air kerma 800 mGy free-in-air using five X-ray beam qualities (60,80,100,120 and 140 kVp) in a SSDL.The measurement for each energy was normalized to 80 kV to analyze energy dependence of films.The films were calibrated to different dose level (0.025-10 Gy) onphantom by 80 kV X-rays.The response curve were plotted to analyze sensitivity and dose response.The films were scanned with Epson V750 commercial flatbed scanner.Color channel analysis was performed.Results The post-exposure gray growth of XR-RV3 film was found to be fairly stable.The change were 2％,4％,6％ at 24 h,72 h and 6 weeks after exposure respectively.EDR2 film was found to be more sensitivity than XR-RV3 film in low dose.The energy response of the XR-RV3 film and EDR2 film were within 9％ and 23％ over the clinical diagnostic x-ray energies,respectively.In the dose range of 0.025-10 Gy,for the XR-RV3 film,the red channel with the dose response curve was most obvious.For EDR2 film,the pixel value of three color channels was coincident.The EDR2 film appeared to be saturated when receiving doses greater than 500 mGy.Conclusions The XR-RV3 film is superior to EDR2 film in gray growth,energy dependence,dose-response and other aspects.This film is very suitable for measuring and analyzing PSD of patients in interventional radiology procedures.

Objective To assess the feasibility of ESD measurements in the mammography by the comparative study of energy dependence of the three passive solid detectors on low energy X-ray.Methods Two thermoluminescent TL) detectors ( LiF(Mg,Ti) and LiF( Mg,Cu, P) and one optically stimulated luminescence (OSL) detector( Al2O3: C ) were irradiated for the same air kerma by ten kinds of beam quality between 25-40 kV in a Mo/Mo low energy X-ray generator,respectively. Results The energy dependences of TL and OSL were 25% and 11% between 25-40 kV, respectively. Conclusions considerable potential for OSL detector can be used in routine quality control and ESD measurements in the mammography.

Objective To identify the steps with potentially higher risk through the analysis of human factors in clinical PET application so as to provide the efficient measures to reduce the risk of potential exposures.Methods The basic data were obtained through field investigation, questionnaire,failure mode, risk identification, FMECA and expert's evaluation, with statistical analysis made.Comparison was made of the relative risk values of automatic encapsulation equipment and manual encapsulation ones.Results The 10 steps with potentially higher risks were identified through analyzing human factors of clinical PET application, of which 8 occurred in the phase of chemical synthesis.The measures to control risk were addressed for the steps with higher risk.The results show that the relative risk value of the clinical process with automatic encapsulation equipment was 2.28 ± 0.99 and the one with manual encapsulation equipment was 3.20 ± 2.01 ( t = 2.56, P ＜ 0.05 ), with the latter being 76% of the former.Conclusions Failure mode and FMECA are effective in risk evaluation of clinical PET application, which can provide important basis for risk control.

Objective To measure the peak skin dose (PSD) in two cardiovascular interventional procedures,including coronary angiography (CA) and percutaneous transluminal coronary angioplasty (PTCA) using radiochromic film.Methods Gafchromic XR-RV3 film was selected to measure PSD in two hospitals.The films were placed on the table underneath the patient during interventional surgery.The kV,mA,fluoroscopy time,dose-area product (DAP),and cumulative dose at reference point and other relevant information were recorded for all cases.Using the Epson V750 flatbed scanner for scanning and analyzing film,FilmQA software was chosen to analyze the pixel value of red,green and blue color channels.The PSD was determined using red channel data.The correlation and linear regression analysis between PSD and device-displayed parameters was carried out.Results PSD were measured using XR-RV3 film for 26 CA and 19 CA + PTCA procedures.For CA procedures,maximum fluoroscopy time,cumulative dose and DAP were 17.62 min,1 498.50 mGy and 109.68 Gy · cm2,respectively.The maximum PSD was 361.20 mGy.However,for CA + PTCA procedures,maximum fluoroscopy time,cumulative dose and DAP were 64.48 min,6 976.20 mGy and 5 336.00 Gy· cm2,respectively.One patient with CA + PTCA procedures was found to have received the PSD value more than 2 Gy,up to 2 195.70 mGy.DAP was found to be a good indicator (R2 =0.815,P ＜0.05) of PSD for CA procedure,and correlated with cumulative dose (R2 =0.916,P ＜ 0.05) for CA + PTCA procedures.Conclusions The PSD value of some patients in cardiac interventional procedures would exceed 2 Gy,the threshold of deterministic effects recommended by ICRP.The dose-related parameters value showed on DSA device can only used to estimate PSD roughly.Using XR-RV3 film accurate measurement of the PSD in interventional projects is a very fast and effective method.