China ; Humans ; Poisoning ; prevention & control ; Public Health ; Public Health Administration ; World Health Organization ; Wounds and Injuries ; prevention & control

With the reform and development of higher education in China,cultural quality education in universities has obtained great achievement through practice of more than ten years.In 21st century,universities' cultural quality education is faced with new situation and tasks.Based on the existing experience,the universities should enhance understanding of cultural quality education,strengthen theoretic research and improve the whole quality of teachers,which can promote the popularization and sustainable development of cultural quality education.

The Sprouty protein can inhibit cel proliferation and induce apoptosis by specific interventions in the signaling pathways of tumor cells, such as receptor tyrosine kinase signaling pathway. The Sprouty protein, which is often associated with abnormal cell proliferation and transformation, is down-regulated in many tumors, stimulating the initiation and progression of tumors. The Sprouty protein exhibits potential for developing effective treatment against cancer. This paper reviews research progress on Sprouty protein in tumor.

ObjectiveTo compare the difference effects on the proximal stomach in rapid(intake rate 100 mL/min) and slow(intake rate 15 mL/min) LNLT.Methods Forty healthy subjects received both the rapid and slow LNLTs.The caloric density of the nutrient was 1 kcal/mL. The TVDRI and MVDRI were recorded,and the corresponding TVPS and MVPS were measured by B-ultrasound.Results(1) There were positive correlation was identified between TVDRI and TVPS,and between MVDRI and MVPS in both slow and rapid LNLTs.(2) TVDRI and MVPS in slow LNLT were significantly smaller than those in rapid LNLT,but MVDRI was significantly larger in slow LNLT than that in rapid LNLT.(3) TVDRI was much closer to TVPS in slow LNLT than those in rapid LNLT.But MVDRI was much closer to MVPS in rapid LNLT than those in slow LNLT.Conclusion Both slow and rapid LNLTs could be used to evaluate the accommodation to a meal and visceral sensitivity of the proximal stomach.The visceral sensitivity is related to the accommodation function.TVDRI of slow LNLT is more sensitive in estimating the visceral sensitivity of the proximal stomach;MVDRI of rapid LNLT is more accurate in estimating the accommodation of the proximal stomach.

Gout is a metabolic inflammatory disease characterized by hyperuricemia. When serum uric acid concentration(sUA) is greater than 420 μmol/L, monosodium urate(MSU) crystals are formed and deposited in joints and connective tissues, resulting in acute gout arthritis. In addition to the concentration of urate, pH is also one of the factors affecting MSU deposition. Lowering pH can promote MSU crystallization. Urine alkalization can raise the pH to 6.2~6.9, which can increase the solubility of urate to prevent MSU deposition and the formation of uric acid stones. Commonly used clinical medications include citrate, bicarbonate, acetazolamide, tromethamine, etc. Among them, potassium citrate is the most commonly used alkali agent in clinical practice. However, due to adverse drug reactions, clinical medications need to be cautious. In addition to pharmacotherapy, dietary intervention has also become an important means of alkalizing urine. When sufficient attention is paid to the construction of a balanced diet, dietary intervention will become a safe and economical method for the treatment of gout, but the long-term efficacy has not been determined. This article discusses the advantages and disadvantages of urine alkalinization in the application of hyperuricemia and gout from aspects of pharmacological treatment and diet management, and provides a basis for proper medication use.

Objective: To observe the clinical efficacy of acupuncture plus auricular point sticking for tension-type headache (TTH). Methods: A total of 90 TTH patients were divided into an acupuncture group, an auricular point sticking group and an observation group by random number table method, with 30 cases in each group. Patients in the observation group received acupuncture plus auricular point sticking for treatment, while those in the acupuncture group only received acupuncture and those in the auricular point sticking group only received auricular point sticking for treatment. The headache attack frequency and the scores of visual analog scale (VAS), self-rating anxiety scale (SAS) and self-rating depression scale (SDS) were observed before treatment, after treatment and 3 months after treatment. The clinical efficacy was evaluated at the follow-up of 3 months after treatment. Results: At follow-up, there were significant differences in clinical efficacy among the three groups (P<0.01 or P<0.05), and the clinical efficacy ranking from high to low was the observation group, the acupuncture group and the auricular point sticking group. After treatment and at follow-up, the VAS score, headache attack frequency, SAS and SDS scores in the three groups were significantly lower than those before treatment (all P<0.01). The above four results in the observation group were lower than those in the acupuncture group and the auricular point sticking group at the same time point (all P<0.01); VAS score in the acupuncture group was lower than that in the auricular point sticking group (both P<0.05). At follow-up, the headache frequency in the acupuncture group was lower than that in the auricular point sticking group (P<0.05). Conclusion: Either using acupuncture and auricular point sticking together or separately can reduce the headache degree of TTH patients, reduce the number of headache attacks, and relieve anxiety and depression. The efficacy of acupuncture plus auricular point sticking is most significant.

Objective To investigate whether dobutamine could induce or worsen electromechanical activity synchronism in the patients with idiopathic dilated cardiomyopathy(DCM). Methods Eighteen patients with DCM[mean age ( 45.8 ? 13.9 ) years, NYHA class Ⅱ-Ⅲ, left ventricular ejection fraction(LVEF)

Periventricular leukomalacia (PVL) is the predominant form of brain injury and the main cause of cerebral palsy and cognitive deficits in premature infants. The number of low-birth-weight infants, who survive to demonstrate these neurologic deficits, is increasing. The factors of PVL are ischemia and inflammatory reaction which cause interaction of glutamate and free radicals. Pre-oligodendroglia is highly vulnerable to death caused by their interaction leading to neuropathologic hallmarks of PVL, and resulting in cerebral palsy. It is suggested that the preservation of occurrence and development of PVL is the key for depressing incidence rate of cerebral palsy. Pharmacologic interventions that target these toxic molecules will be useful in diminishing the severity of PVL accordingly to decreasing or lessening cerebral palsy in premature infants..

Sunitinib malate (SU11248 ,Sutent) is an orally available small-molecule multitargeted tyrosine kinase inhibitor that has potent anti-angiogenic and antitumour activities.In 2006 sunitinib was approved by FDA for imatinib intolerant gastrointestinal stromal tumors (GIST) patients or imatinib resistant GIST patients.This article review the molecular-based mechanism,the mechanism of resistance,the biomarker,the clinical trials and the adverse effects of sunitinib in the treatment of imatinib-resistant GIST.