1.Advances in clinical treatment of MALT lymphoma
Chinese Journal of Radiation Oncology 2017;26(8):956-960
Mucosa-associated lymphoid tissue (MALT) lymphoma often occurs in the stomach as well as the head and neck.This disease has characteristics of multi-site dissemination and indolent development,and about 80% of MALT lymphoma patients are in early stage.Helicobacter pylori (Hp) eradication is the main method for treating early-stage Hp-positive gastric MALT lymphoma.For patients with other types of early-stage MALT lymphoma and those with gastric MALT lymphoma who failed Hp eradication therapy,radiotherapy has a good clinical effect.In recent years,radiotherapy target volume has changed from the involved field to the involved site,and the dose has been decreased.This article provides a review of the above aspects.
2.Surgical treatment for eyelid basal cell carcinoma
Ophthalmology in China 2006;0(06):-
Objective To observe the curative effect of surgical treatment for eyelid basal cell carcinoma. Design Retrospective case series. Participants 33 cases with eyelid basal cell carcinoma. Methods 33 cases with eyelid basal cell carcinoma treated with surgery, standard excision in 17 case and Mohs micro excision in 16 cases were analyzed, postoperative appearance and function of re- eonstruetiiv eyelid, reeurence rate and survival rate were observed by follow-up survey. Main Outcome Measures Postoperative ap- pearance, function of reconstruetiiv eyelid, recurence rate and survival rate. Results After 6 month ~ 5 years follow-up survey with an average of 2.5 years, 28 of 29 cases obtained normal eyelid appearance, 1 case with lower eyelid gentle ectropium. 11 cases showed hy- perpigmentation in skin-grafting area in early stage, and became normal in half a year. Eyelid function of 29 cases were normal. Tumour relapse was seen in one case 2 years after standard resection,the cure rate was 94.12%. No tumor relapse was seen in group of mohs micro resection, the cure rate was 100%. Within five years postoperation, there was no death case caused by basal cell carcinoma re- lapse, except one dying from myocardial infarction and another dying of eerebrovaseular disease. Conclusions Operational excision is an effective approach for eyelid basal cell carcinoma. The effect of mohs micro resection is better than the one of standard resection. With dissociate skin grafting, fluctuate tarsal transmigration and dissociate skin grafting, eyelid appearance and function recover well.
3.Analysis on corneal spherical aberration in patients with cataract in Kaifeng area
International Eye Science 2016;16(11):2133-2135
AIM:To find out the mean corneal spherical aberration and its changes with age in Kaifeng population.
METHODS: A total of 466 eyes of 427 Kaifeng subjects with cataract, whose age ranged from 52 to 75 years old, were divided into three groups according to the age. All the subjects were included in measuring K-readings of cornea, the corneal anterior and posterior surfaces of the spherical aberration and the total corneal spherical aberration using Pentacam(Oculus, Germany) at the 6-mm optical zone.
RESULTS:The mean corneal spherical aberration( CSA) of the whole groups was 0. 339±0. 153μm. Patients from 50 to 60 years old had CSA of 0. 322±0. 137μm, 0. 326±0.157μm was the CSA of the patients from 60 to 70 years old, while those from 70 to 80 years old have a CSA of 0.401 ± 0. 182μm. The corneal K - readings had no correlation with the total corneal spherical aberration ( r=0. 034, P>0. 05), anterior surfaces CSA, posterior surfaces and total CSA were positively correlated with age ( r =0.253, 0. 327, 0. 233, all P<0. 01).
CONCLUSION:CSA is varied among the population and CSA of elderly in Kaifeng area are slightly higher than white people, and positively correlated with age.
4. Design and application of fiberoptic bronchoscopy training box
Academic Journal of Second Military Medical University 2010;29(6):691-693
Objective: To design and prepare a fiberoptic bronchoscopy training box and to study its primary application. Methods: According to the length of optical fiber, the height, the length and the width of the box were set at 400 mm, 200 mm and 200 mm. The box contained 6 layers from the top to the bottom: the top-layer, layer-A, layer-B, layer-C, layer D and the bottom layer, with the area of each layer being 200 mm × 200 mm and the distance between each 2 layers was about 80 mm. According to the diameter of optical fiber, the diameter of the holes was set at 6 mm. Except for the bottom-layer, the other 5 layers had different numbers of holes: the top-layer and layer-A only had a central hole(central hole in every layer was defined as hole-0), layer B had 5 holes(hole-0 to 4), layer C had 9 holes(hole-0 to 8), layer D had 17 holes(hole-0 to 16). The training started from the top-layer. The orders were given according to the layers and the numbers of the holes and the orders were executed, then the box was open to examine the outcome of the execution. Results: We successfully designed a fiberoptic bronchoscopy training box. If the training instruction order was A0-B2-C4-D7, the trainees should manipulate the optical fiber via the central hole in top-layer and layer-A, hole-2 in layer B, hole 4 in layer-C, and hole-7 in layer-D. The results of manipulation can be examined after opening the door. Conclusion: The fiberoptic bronchoscopy training box is a easy-to-operate and practical tool for training of fiberoptic bronchoscopy manipulation.
5.Influence of acute hypoxia on current of voltage-gated potassium channel in pulmonary artery smooth muscle cells of rats
Jinshan KE ; Yimei DU ; Qinmei KE ; Li TIAN ; Yuanzhou ZHU
Chinese Journal of cardiovascular Rehabilitation Medicine 2013;22(5):435-440
Objective: To study influence of acute hypoxia on the current of voltage-gated potassium channel (IK) in pulmonary artery smooth muscle cells (PASMC) of rats. Methods: A total of 20 male SD rats were randomly and equally divided into normoxic control group and acute hypoxia group. The rats in acute hypoxia group were kept in hypoxic chamber for 8 h before experiment. Whole cell patch-clamp technique was used to record IK in PASMC. Results: Acute hypoxia significantly decreased the IK density in PASMC of rats. During -60mV to -10mV of resting membrane potential(RMP), acute hypoxia did not significantly decrease peak IK density in PASMC of rats, P>0.05; At 0 mV, acute hypoxia significantly decreased the peak IK density in PASMC [from(38.1 ± 5.2) pA / pF decreased to(9.82 ± 2.1) pA / pF ,P<0.05], then along with RMP increase in PASMC, the decreasing amplitude of peak IK density in PASMC gradually increased(P<0.05); From + 30 mV to+ 60 mV, the decreasing amplitude of peak IK density in PASMC further significantly increased(P<0.01); At + 60 mV the peak IK density decreased from(38.1 ± 5.2) pA / pF to(9.82 ± 2.1) pA / pF , and the decreasing amplitude reached (46.8±3.3)%. Conclusion: Acute hypoxia can decrease Kv current in PASMC of rats, leading to hypoxic pulmonary vasoconstriction.
6.A new phenylpropanoid glycoside from Cirsium setosum.
Rui KE ; Enyuan ZHU ; Guixin CHOU
Acta Pharmaceutica Sinica 2010;45(7):879-82
To study the chemical constituents of Cirsium setosum (Willd.) MB., 70% ethanol extract of the aerial parts was subjected to column chromatography. One new phenylpropanoid glycoside, sinapyl alcohol 9-O-(E)-p-coumaroyl-4-O-beta-D-glucopyanoside (1) was isolated, along with three known compounds: lycoperodine-1 (2), apigenin-7-O-(6"-(E)-p-coumaroyl)-beta-D-galactopyranoside (3) and quercetin (4). The structures were elucidated on the basis of spectral and chemical evidence. Compound 2 was obtained from Cirsium genus for the first time, compounds 3 and 4 were obtained from this plant for the first time.
7.Association of resting heart rate with dyslipidemia
Hongmei XIAO ; Ke ZHU ; Xun FU
Clinical Medicine of China 2010;26(11):1155-1157
Objective To investigate the association between resting heart rate(RHR)and dyslipidemia. Methods A total of 772 subjects(average age:40. 1 ± 11.8 years;male:74. 7%)were recruited by random sampling method from medical checkup population. The survey data included resting heart rate,blood lipid and other metabolic parameters. The subjects were divided into three groups according to the RHR,as RHR < 70 bpm,70 bpm ≤ RHR < 80 bpm,RHR ≥ 80 bpm groups. Results RHR were positively correlated with triglyceides (TG),as well as total cholesterol(TC)(r = 0. 316 and r = 0. 110 respectively,all P value < 0. 05). Low RHR had no significant correlation with HDL-C or LDL-C. The prevalences of hypertriglyceridemia and hypercholesterolemia increased significantly with RHR elevation(χ2 = 7. 214 and 5. 285 respectively,all P value < 0. 05). By logistic regression analysis,adjusted for BMI,gender,serum creatinine,serum uric acid,fasting blood glucose and age,we found that compared with RHR < 70 bpm group,the odds ratio(OR)values for hypertriglyceridemia was 1. 540 (95%CI:1. 086-2. 185,P=0. 016)in 70 bpm≤RHR <80 bpm group and 1.640(95% CI:1.067 -2.523,P =0. 024)in 80 bpm ≤ RHR group,and the OR values for hypercholesterolemia was 1.197(95 % CI: 0.749 - 1.913,P=0.453)in70 bpm≤RHR <80 bpm group and 1.814(95% CI:1. 036-3. 177,P =0.037)in 80 bpm≤RHR group. Conclusions RHR is independently and positively correlated with the prevalence of hypertriglyceridemia and hypercholesterolemia and the blood levels of both lipid. RHR has no significant correlation with HDL-C or LDL-C level.
10.Clinical and imaging features of cerebral cortical vein thrombosis
Dan GUO ; Ke ZHU ; Dongxue ZHAO
International Journal of Cerebrovascular Diseases 2016;24(1):23-28
Objective To investigate the clinical and imaging features of cerebral cortical vein thrombosis (CoVT). Methods The clinical data of 13 inpatients with CoVT were enroled from September 2010 to September 2015. The etiology, clinical symptoms, imaging features, and differential diagnosis of CoVT w ere summarized and analyzed. Results Among the patients, there w ere 7 females (53.85%) and 6 males (46.15%). Their age ranged from 18 to 59 years (mean 34.23 ±12.08). The most common clinical manifestations were headache (9 patients) and seizures (9 patients). The 13 patients had cerebral parenchymal involvement and they al received anticoagulant therapy. Conclusions The clinical symptoms of CoVT are various. Seizures and headache are the most common symptoms. Most of patients are accompanied by brain parenchymal lesions and venous sinus thrombosis. When patients have headache and seizures, and head images suggest hemorrhagic infarction, imaging examination of the improvement of the cerebral venous system thrombosis is recommended.