Objective:To systematically evaluate the clinical efficacy and adverse effects of Janus kinase (JAK) inhibitors in the treatment of Coronavirus Disease 2019 (COVID-19).Methods:Meta-analysis of the clinical efficacy and adverse effects of Janus kinase inhibitors in the treatment of COVID-19 was performed on 19 papers that met the inclusion criteria, including tests for heterogeneity, relative risk ( RR), mean difference( MD) and publication bias. Results:For the Janus kinase inhibitor group compared with the control group in 19 studies, RR and 95% confidence interval (95% CI) were 0.52 (95% CI: 0.44-0.62), 0.45 (95% CI: 0.25-0.83), and 1.21 (95% CI: 1.03-1.43) for mortality, clinical deterioration and recovery rates, and the mean difference and 95% CI in recovery time was -0.96 (95% CI: -1.13--0.79); for adverse events (including serious adverse events, infections, embolism, deep vein thrombosis, pulmonary embolism, liver dysfunction, psychiatric disorders, renal and urinary disorders), only the P-value for serious adverse events was statistically significant, P=0.010, and the RR and 95% CI were 0.83 (95% CI: 0.72-0.97). Conclusions:JAK inhibitors help reduce mortality and improve clinical outcomes in patients hospitalized with COVID-19 without increasing the risk of adverse events.

Objective:To investigate the survival of 2019 novel coronavirus (2019-nCoV) on the surface of inanimate objects at different temperatures.Methods:CNKI, WanFang Database, VIP, PubMed, Web of Science, Cochrane Library and Embase were searched for articles published from January 1, 2020 to June 15, 2022 with "2019-nCoV, surface, inanimate, environments, environmental, matrices, factors, conditions, contact, personal protective equipment, transmission, stability, persistence, viability, survival, survivability, infectivity, transmission". The literature was screened according to the inclusion and exclusion criteria. After the data in the literature were extracted, the improved MINORS scale was used to evaluate the literature quality. RevMan5.4 software was used for meta analysis, and Stata17.0 software was used for Begg′s test and Egger′s test to evaluate the publication bias.Results:A total of 20 studies were included. Meta-analysis result showed that the survival ability of 2019-nCoV on the surface of non-porous objects (stainless steel, glass and plastic) was significantly different from that on the surface of porous objects (cloth, wood board, banknote, cotton, cardboard) ( Z=5.94, P<0.001; Z=17.85, P=0.004; Z=38.20, P<0.001). The result of subgroup analysis showed that there was no significant difference in the survival ability of the virus between banknotes and glass, plastic surfaces under the same conditions ( Z=0.81, P=0.420; Z=1.79, P=0.070). The half-life of the virus at 4 ℃ was significantly different from that at 25 ℃[ MD=47.49 h, 95% CI: 7.00~87.99, Z=2.30, P=0.020]; The half-life of the virus at 25 ℃ was also significantly different compared with that at 35 ℃[ MD=5.46 h, 95% CI: 0.13~10.78, Z=2.01, P=0.040]. Conclusions:Under the same conditions, the survival time of 2019-nCoV on the surface of nonporous objects was longer than that on the surface of porous objects, and the higher the temperature, the shorter the survival time.