China ; Humans ; Poisoning ; prevention & control ; Public Health ; Public Health Administration ; World Health Organization ; Wounds and Injuries ; prevention & control

With the reform and development of higher education in China,cultural quality education in universities has obtained great achievement through practice of more than ten years.In 21st century,universities' cultural quality education is faced with new situation and tasks.Based on the existing experience,the universities should enhance understanding of cultural quality education,strengthen theoretic research and improve the whole quality of teachers,which can promote the popularization and sustainable development of cultural quality education.

The Sprouty protein can inhibit cel proliferation and induce apoptosis by specific interventions in the signaling pathways of tumor cells, such as receptor tyrosine kinase signaling pathway. The Sprouty protein, which is often associated with abnormal cell proliferation and transformation, is down-regulated in many tumors, stimulating the initiation and progression of tumors. The Sprouty protein exhibits potential for developing effective treatment against cancer. This paper reviews research progress on Sprouty protein in tumor.

ObjectiveTo compare the difference effects on the proximal stomach in rapid(intake rate 100 mL/min) and slow(intake rate 15 mL/min) LNLT.Methods Forty healthy subjects received both the rapid and slow LNLTs.The caloric density of the nutrient was 1 kcal/mL. The TVDRI and MVDRI were recorded,and the corresponding TVPS and MVPS were measured by B-ultrasound.Results(1) There were positive correlation was identified between TVDRI and TVPS,and between MVDRI and MVPS in both slow and rapid LNLTs.(2) TVDRI and MVPS in slow LNLT were significantly smaller than those in rapid LNLT,but MVDRI was significantly larger in slow LNLT than that in rapid LNLT.(3) TVDRI was much closer to TVPS in slow LNLT than those in rapid LNLT.But MVDRI was much closer to MVPS in rapid LNLT than those in slow LNLT.Conclusion Both slow and rapid LNLTs could be used to evaluate the accommodation to a meal and visceral sensitivity of the proximal stomach.The visceral sensitivity is related to the accommodation function.TVDRI of slow LNLT is more sensitive in estimating the visceral sensitivity of the proximal stomach;MVDRI of rapid LNLT is more accurate in estimating the accommodation of the proximal stomach.

Objective To investigate the correlation of serum alpha-fetoprotein (AFP) with clinical pathological factors and prognosis of hepatocellular carcinoma ( HCC ).Methods Two hundred and twenty patients with HCC who hospitalized in our hospital from January 2007 to June 2009 were enrolled in this study.The relationship of AFP levels before operation to clinical pathological factors such as pathological grade,tumor size,tumor encapsulation,tumor numbers,portal vein tumor thrombus,TNM stage and postoperative recurrence were analyzed.Results Serum AFP concentration before operation were related with tumor size ( x2 =11.76,P ＜ 0.05 ),tumor encapsulation ( x2 =17.07,P ＜ 0.05 ),portal vein tumor thrombus ( x2 =8.944,P ＜ 0.05 ),higher TNM stage ( x2 =4.929,P ＜ 0.05 ) and early postoperative recurrence rate ( x2 =5.569,P ＜ 0.05 ).However,it had no correlation with pathological edmondson grade tumor numbers.Conclusion HCC patients with high serum AFP concentration often has greater tumor without encapsulation,high occurrence rate of portal vein tumor thrombus and higher TNM stage,they are more likely to early postoperative recurrence.Serum AFP before operation is useful not only for diagnosis,but also as a prognostic biomarker to predict prognosis and recurrence.

Sunitinib malate (SU11248 ,Sutent) is an orally available small-molecule multitargeted tyrosine kinase inhibitor that has potent anti-angiogenic and antitumour activities.In 2006 sunitinib was approved by FDA for imatinib intolerant gastrointestinal stromal tumors (GIST) patients or imatinib resistant GIST patients.This article review the molecular-based mechanism,the mechanism of resistance,the biomarker,the clinical trials and the adverse effects of sunitinib in the treatment of imatinib-resistant GIST.

Objective To evaluate atrial stunning after successful cardioversion in patients with atrial fibrillation by utilizing tissue Doppler imaging(TDI),M-mode echocardiography in left atria-ventricuhr annulus motion,together with pulsed Doppler echocardiography and apexcardiogram.Methods Thirtyeight patients with atrial fibrillation who in 1 hour after successfully underwent electrical or pharmacological cardioversion were involved.The peak motion velocity of mitral annulus during atrial contraction period(Am)and peak motion velocity during early diastolic period(Em) was detected by TDI.The biggest motion argument of mitral annulus during atrial contraction period(DAD)and biggest motion argument during early diastolic period(DED)was detected byM-mode echocardiography.The blood flow velocity of mitral during early diastole(E)and atrial contraction(A) was also measured by pulsed Dopphr echocardiography and pressure wave during atrial systole was recorded by apexcardiogram.The patients were divided into two groups according to whether they had atrial stunning(atrial stunning group and non-atrial stunning group).Results The incidence of atrial stunning occurred in left atrium was 28.9%(11/38)at 1 hour after successful cardioversion.There was no significant difference in cardioversion method between two groups(P>0.05).The patients in atrial stunning group had longer duration of atrial fibrillation and Larger left atrium(P<0.05).A,Am and DAD in the atrial systole period in atrial stunning group was 0.but in non-atrial stunning group was(43±34)cm/s,(6±4)cm/s,(0.27 ±0.18)cm,respectively,and there were significant difference between two groups(P<0.05).Conclusion Atrial stunning can happen in left atrium after successful cardioversion,and atrial stunning is related to the duration of atrial fibrillation and the dimension of left atrium.

Objective To explore the correlation between prethrombotic state (PTS)and chronic atrial fibrillation in elderly patients,and to analyze the risk factors.Methods A total of 142 elderly patients with chronic atrial fibrillation from May 2009 to May 2011 were selected.Patients were divided into the PTS group (n =90) and no-PTS group (n =52) by transesophageal echocardiography (TEE).The left atrial diameter (LAD),left ventricular ejection fraction (LVEF),levels of high-sensitivity c reactive protein (hs-CRP),D-Dimer (D-D),β-platelet globulin (β-TG),B type brain natriuretic peptide (BNP),P-select element (PS),endothelial damage/dysfunction mark (vWF) and platelet aggregation rate-AA (PAR-AA)were determined.The related factors of prethrombotic state in elderly patients with chronic atrial fibrillation were analyzed by the multiple regression analysis.Results There were significant differences in the time of atrial fibrillation,frequency of patients with mitral regurgitation,levels of hs-CRP,D-D,β-TG,BNP,PS,vWF and PAR-AA between the PTS group and the non-PTS group [(6.9±1.8)years vs.(4.7±1.3)years,39 cases (43.3％)vs.11 cases (21.2％),(7.8±1.0)mg/L vs.(2.7±0.4)mg/L,(706.6±38.1)μg/L vs.(270.4±28.5)μg/L,(147.2± 21.3) μg/L vs.(117.7±17.1)μg/L,(1075.4±31.2)ng/L vs.(222.6±26.0)ng/L,(88.5±13.9)μg/Lvs.(37.4±11.2)μg/L,(36.1±11.2) ×10-3U/L vs.(26.4±9.9)×10-3U/L,(27.4±12.6)％ vs.(19.7±5.7)％,t=4.52,11.18,15.31,31.20,4.89,166.46,22.59,14.06,5.45,respectively,all P＜0.01].Multivariate logistic regression analysis showed that the time of chronic atrial fibrillation,mitral regurgitation,levels of hs CRP,PS,vWF and PAR-AA were independent risk factors for PTS in elderly patients with atrial fibrillation (OR=3.57,2.19,2.91,3.28,2.37,1.98,respectively,all P＜0.05).Conclusions The time of atrial fibrillation,mitral regurgitation,levels of hsCRP,PS,vWf and PAR-AA are independent risk factors for PTS in elderly patients with chronic atrial fibrillation.

24 dogs for experiments were divided into 3 groups: total splenectomy, sham-operation and splenic autologous transplantation (SAT). Results of the study showed that in dogs the SAT (each splenic piece size 110.5 cm) into the omental pouch did survive well,and restore a part of function. The function of neutro-phil chemoluminescence and the phagocytosis rate of neutrophils, after splenectomy, in vitro, were lower than that of sham-operation group. The dogs of SAT could give some protective action, but the number of T-lymphocytes in splenic corpuscles and mononuclear phagocytes in splenic red pulps in regenerated splenic tissue were lower that of normal splenic tissue.

Objective To assess the effects of intraventricular conduction abnormality on left ventricular function in dilated cardiomyopathy. Methods The study composed of 3 groups,16 patients of dilated cardiomyopathy (DCM) without wide QRS complexes, 16 patients of DCM with complete left bundle branch block(CLBBB),and 16 age-matched healthy individuals,all showing sinus rhythm and being complicated with mitral regurgitation. Pre-ejection contraction time(PET), left ventricular ejection time(LVET), left ventricular filling time(LVFT), myocardial performance index(MPI), mitral regurgitation time(MRT), stroke volume(SV) were recorded with pulsed or continuous-wave Doppler. Pulse tissue Doppler imagining(TDI) was performed to measure the time dispersity of electromechanical motion of left ventricular in systole and diastole on the atrial-ventricular annulus with mapping techniques. Results Time dispersity of electromechanical motion of adjacent left ventricular segments in systole[((77.9)?(13.6))ms vs ((52.1)?(13.2))ms vs ((28.3)?(7.2))ms, P