Objective To investigate the effect and safety of Batroxobin (DF-521) combined with Aspirin (ASA) in the treatment of acute cerebral infarction. Methods 102 patients with acute cerebral infarction were enrolled in the study and all the patients were divided into three groups: ASA group (n=23), Batroxobin group (n=35) and ASA combined with Batroxobin group (n=44). Platelet count, blood viscosity, platelet aggregation test (PAgT), fibrinogen, coagulation studies (PT, APTT, INR), TXB2, imaging, National Institutes of Health Stroke Scale (NIHSS) and Modified Barthel Index (MBI) were measured or assessed before and after treatment, respectively. Hemorrhage rate (including brain and other organs) as one of complication was also investigated.Results After treatments, ASA combined with Batroxobin group showed the strongest inhibition of platelet aggregation among the three groups (all P0.05). A follow up of 3 months showed that the scores of NIHSS and MBI in ASA combined with Batroxobin group were better than those in the other two groups (all P

Objectives:According to the present structural characteristics, the safety and the functional states of the old hyperbaric oxygen cabin used in our hospital for about 30 years, new techniques were rationally used in the reformation of the old cabin. And to keep the cabin in the first level in the country for its advancement, preeminence and technical contents in the safety and utility. Methods:Correctly understand the present national standards and regulations, carefully design the reformation plan after a thorough investigation, research and proof. And the reformation construction unit was chosen by public bidding after approved by the competent authorities of the local state. The local competent authorities and the specialized personnel in the hospital were invited during the reformation construction to exam and supervise on the spot. After the accomplishment of the reformation construction, the provincial and city competent authorities and the corresponding experts in this specialized field were invited to check and accept. Results:The check and acceptance report showed that the reformation construction was meticulous in the design and construction, the technological level was high, and several new advanced techniques had been used. The hyperbaric oxygen cabin after the reformation had a high safety and comfort. Some of the indexes had exceeded the present national standards, and achieved the national advanced standards for large medical hyperbaric oxygen cabins. Conclusions:Old cabins can be fully reformed into first level cabins in technical advancement and safety.

Objective To test the reliability of the Chinese version of tridimensional personality questionnaire(TPQ) and to explore three-dimentional personality characteristics of heroin dependence. Methods Personality characteristics of 358 heroin dependers,114 male smoker and 200 normal controls were investigated using the TPQ. 78 heroin depender were examined 10 days later to test the reliability of TPQ.Results (1) Retest reliabilities of the three higher-order dimensions of the novelty seeking(NS),reward dependence(RD) and harm avoidance(HA) were all good( r =0.87,P <0.01;r =0.84,P <0.01,r =0.64,P <0.01).The dimension's Alpha split of NS or HA were 0.72 and 0.71,respectively. While RD's Alpha split was just 0.29. (2) NS was higher but not significantly in the heroin-dependenc group than normal controls(P =0.09),but the former had significantly higher HA and lower RD [(15.25±5.95) vs (13.22±6.27),t =13.65,P <0.01;(17.08±3.28) vs(18.29±3.83),t =15.07,P <0.01]. (3)There were significantly sex differences in all the three higher-order dimensions of TPQ in the heroin-dependence group( P <0.01). Male heroin dependers had significantly higher NS ,higher HA and lower RD than male controls[(16.99±4.76) vs(15.29±4.60), P =0.002;(14.46±6.01) vs (12.31±6.00),P =0.002],and male heroin dependers had significantly higher NS,lower RD than male smokers( P <0.001).Compared with female controls,female heroin dependers only had significantly higher HA.Conclusion Reliability of the TPQ is good. Sex difference in personality characteristics of heroin depender exits. Male heroin depender have high NS,high HA,and low RD,which can provide scientific data for early intervention of heroin dependence.

Cochlear Implantation ; adverse effects ; methods ; rehabilitation ; Hearing Tests ; Humans

AIM: To evaluate the effects of different doses of valsartan alone or with concomitant benazepril on blood pressure, left ventricular hypertrophy, RAAS function and endoxin level in spontaneously hypertensive rats (SHR). METHODS: Thirty SHR (fourteen-week-old, male) were divided into five groups (six rats in each group ): SHR control group: fed with normal saline; benazepril group: fed with 1 mg?kg -1 ?d -1 benazepril); low dose valsartan group: fed with 8 mg?kg -1 ?d -1 valsartan ; high dose valsartan group: fed with 24 mg?kg -1 ?d -1 valsartan ; combination drug therapy group: fed with valsartan (8 mg?kg -1 ?d -1 ) and benazepril (1 mg?kg -1 ?d -1 ), all for 8 weeks. WKY control group (n=6):fed with normal saline for 8 weeks.RESULTS: SBP, LVM/BW,TDM of SHR were remarkably lower than those of control after drug intervene, and effect on SBP was most remarkable in high dose valsartan group and in the combination drug therapy group; effect on LVM/BW,TDM were most remarkable in combination drug therapy group. Renin activities in plasma and myocardium were remarkably increased in drug intervene groups. The levels of Ang Ⅱ in plasma and myocardium were remarkably increased in two different dose of valsartan treating group, and the larger dose of valsartan were, the higher levels of Ang Ⅱ in plasma and myocardium were; decreased in benazepril treating group and combination drug therapy group. Na +-K +-ATPase activities in myocardium were remarkably increased and the level of endoxin in myocardium were remarkably decreased as SBP decreased after drug intervene. CONCLUSION: Different dose of valsartan alone or combined with benazepril can decrease SBP of SHR, have the effect of inhibiting progression of ventricular hypertrophy. The effect of combination drug therapy group was most remarkable among five groups and can avoid the side effect of high AngⅡ in plasma and myocardium during long-term use of valsartan alone.

Cardiomyopathy, Dilated ; diagnosis ; therapy ; Europe ; Humans ; United States

Objective To study the effect of Yinxingdamo (compound of ginkgo biloba extract) on hemodynamics of cerebral circulation in patients with acute cerebral infarction (ACI). Methods Sixty patients with first ACI of carotid artery system were randomly divided into a treatment group (30 cases) and a control group (30 cases), and treated with the drug Yinxingdamo plus therapeutic exercise and therapeutic exercise, respectively. The cerebrovascular dynamics indexes (CVDI) of both groups were investigated before and after the treatment. Results The Vmin and Qmin of carotid artery in the two groups were increased after treatment and the cerebrovascular resistance (R) was decreased (P

Cardiac Catheterization ; standards ; Heart Defects, Congenital ; therapy ; Humans

Objective To detect the change and clinical significance of homocysteine (Hcy),hypersensitivity C response protein (hs-CRP) and hypersensitivity troponin I (hs-TnI) in patients with acute myocardial infarction (AMI).Methods Ninety-six cases of AMI were selected as the research group and 60 cases of coronary heart disease without AMI were enrolled in the control group.Blood samples were collected to measure the contents of serum Hcy,hs-CRP and hs-TnI.ROC curve was drawn and Logistic regression model was established to analyze the role of each index alone and combined detection in the diagnosis of AMI.Results The levels of Hcy,hs-CRP and hs-TnI in the research group were significantly higher than those in the control group (Hcy: (29.29±7.65) mol/L vs.(17.23±4.68) mol/L;hs-CRP: (15.47±5.01) mg/L vs.(9.21±3.15) mg/L;hs-TnI: (40.88±9.18) ng/mL vs.(7.34±2.12) ng/mL,t=2.78,8.66,34.36,P<0.05).The area under the ROC curve of Hcy,hs-CRP,hs-TnI were 0.802 (95%CI(0.729~0.874)),0.71(95%CI(0.62~0.792)),0.929 (95%CI(0.891~0.967)),respectively.The area under the combine detection curve was 0.971 (95%CI,0.950~0.992).The sensitivity of Hcy,hs-CRP and hs-TnI in the diagnosis of AMI were 79%,57%,87%,respectively,the specificity of the three groups were 72%,70%,90%,the sensitivity and specificity of combined detection were 96% and 88%.Conclusion Combined detection of Hcy,hs-CRP and hs-TnI plays a better role in the diagnosis of AMI than that of Hcy,hs-CRP,hs-TnI alone and has a high specificity and sensitivity in the diagnosis of AMI.