Sepsis is one of the leading causes of death in intensive care unit(ICU)patients,typically resulting from excessive inflammation induced by infection,leading to multiple organ dysfunction syndrome and life-threatening complications.Exosomes are a type of extracellular vesicle that are lipid bilayered nanoparticles secreted by cells.In recent years,numerous studies have demonstrated their involvement in the occurrence and development of sepsis.The various molecular substances carried by exosomes have been shown to regulate sepsis-related inflammation and organ damage.In particular,different types of exosomes hold promise as diagnostic biomarkers for sepsis patients,and also provide new therapeutic targets for improving patient outcomes.This review was conducted on the research progress concerning the relationship between exosomes and sepsis,sepsis associated-acute lung injury(SA-ALI),sepsis associated encephalopathy(SAE),sepsis associated-acute kidney injury(SA-AKI),sepsis associated cardiomyopathy(SIC),and other organ injuries related to sepsis.This study aims to assist in guiding clinical diagnosis and treatment.