In order to testify the hypothesis that sex and age of a patient should be influential factors in the process of selecting the KANPO medicine (Chinese medicine), we statistically analyzed the KANPO prescriptions (4, 848 times in total) which had been given to the outpatients (3, 156 in total number) on the lst visit at the Japanese KANPO Medicine Research center's Shibuya Clinic from the lst of Dec. 1981 through the 30th of Nov. 1982.
The ranking of the medicines, from the most frequently used, was as follows: (1) Males; (1) Shoseiryu-to, (2) Hachimi-gan, (3) Saikokeishi-to, (4) Shosaiko-to, (5) Saikokaryukotsuborei-to, (2) Fermales; (1) Kamishoyo-san, (2) Tokishakuyaku-san, (3) Keishibukuryo-gan, (4) Shoseiryu-to, (5) Keishikajutsubu-to. The difference by sex is apparent.
The distribution of age of the patients were not even in number. So, after correcting this unevenness by a certain calculation, it was studied about each medicine (above mentioned), if there might be some relationship between age and the number of how many times the medicine was prescribed for the patients of corresponding age. As the result, the frequencies of using a certain medicine seemed to be changed in relation to age. Every medicine seemed to have its own pattern in this point of view.
For example, Shoseiryu-to was most often used among the younger patients of both males and females. To the contrary, Hachimi-gan was most often used among the older male. Kamishoyo-san had its peak of usage among 40s' and 50s' female.
These facts seem to justify our hypohesis. We also discussed this problem from the historial view.

This is a case report of primary hyperthyroidism, treated by Shakanzo-To (a herbal medicine) alone, without any other medical intervention. Effects of Shakanzo-To was proved by the measurement of serum thyroid hormone levels.
The patient was 32 y. o. female. Struma and exophthalmus were apparent. Weight loss was also noticable (-10kg/2 years). Serum thyroid hormone levels were abnormally high (T₃=421ng/dl, T₄=36.0μg/dl, TSH=1.0μU/ml). Thyroid scintigram showed diffuse uptake. ¹³¹I uptake ratio was 71.5%/24 hours. She was diagnosed as primary hyperthyroidism. According to the “Sho” (the diagnostic approach of oriental medicine, KANPO), Shakanzo-To (water-boiled) was prescribed. Six weeks afterwards, the hormone levels decreased (T₃=291, T₄=17.3). From that time, we used the same “Shakanzo-To” medicine, but in the form of chemically-extractedgranules. After four weeks, the hormone levels increased again (T₃=291, T₄=24.7). So, we used again the former Shakanzo-To (water-boiled). Then the hormone levels decreased once again six weeks later (T₃=210, T₄=17.3). TSH levels remained less than 1.25μU/ml.
We believe it important that effects of Shakanzo-To seem to be demonstrated by the improvement of the thyroid hormone levels.

Headache is one of patients' major complaints at medical examination. And in Kampo medicine, we select prescriptions for them by taking not only headache, but also other symptoms into consideration.We present five patients with headache, whose symptoms were improved with tokishakuyakusan. Four patients (cases 1 to 4) had a background of menopausal symptoms and one (case 5), menstrual pain. Besides headache, other symptoms, such as vertigo, edema, and numbness of the fingers, were improved with tokishakuyakusan. Goshuyuto was not effective for headache in case 4, though it was effective to some extent in case 5, except for headache during her menstrual period. Headache during the ovulatory phase and/or pre- and early menstrual period disappeared when tokishakuyakusan was added to goshuyuto.Eleven cases of headache treated with toshakuyakusan, including these five cases, revealed that tokishakuyakusan was efficacious against migraine-type headache, which becomes worse during the menstrual period, and coldness. Although tokishakuyakusan should sometimes be distinguished from goreisan or hangebyakujyutsutenmato, it may be effective in patients with so-called “blood pattern” headache, associated with menstrual period and menopausal symptoms, and in patients with a heavy feeling of the head and vertigo.

It is important to treat patients with spleen qi deficiency not only with formulations for their deficiency, but also with formulations to improve qi stagnation.Rikkunshito plus Cyperi Rhizoma, Amomi Semen and Agastache rugosa, which improve qi circulation, was effective in cases 1 and 2 herein.We examined when and how to prescribe kososan with formulations for spleen qi deficiency, with reference to kosharikkunshito. Kososan and rikkunshito were effective in cases 3 and 4.Based on rikkunshito indication, a patient with weaker constitution was prescribed shikunshito (case 8), a patient with diarrhea and vertigo was prescribed shinbuto (cases 5 and 6), and a patient with severe coldness was prescribed ninjinto (case 7).Kososan played a supplementary role in treatment, and can be prescribed with other medicines.Not only gastrointestinal symptoms, but also various other complaints were improved by adding kososan to prescriptions for spleen qi deficiency.

Teian Azai classically described that summer heat was caused by humidity in addition to hot weather. It may occur after becoming chilled while asleep, enjoying the evening cool, and taking cold foods and drinks. Humidity and high temperature prevent qi circulation in the stomach. Therefore, he insisted that goreisan, a formula improving water circulation, could be applied for diverse symptoms caused by summer heat. We present two cases of patients with epigastralgia caused by cold foods and drinks in air-conditioned environments, whose symptoms were improved by goreisan. In prior treatment, anchusan in case1, and rikkunshito in case 2 were not effective for their epigastralgia. Nineteen cases of epigastralgia after taking cold foods and drinks in summer, including these two cases, revealed that goreisan was efficacious against summer epigastralgia with white fur on the tongue and a stuck feeling in the pit of the stomach. Abdominal fluid congestion is a major abdominal sign for an indication of goreisan, but a stuck feeling in the pit of the stomach presented in some effective cases with goreisan. We concluded that epigastralgia caused by cold foods and drinks with white fur on the tongue and a stuck feeling in the pit of the stomach could be a target for the application for goreisan.

Introduction : We evaluated the efficacy of keishito and maobushisaishinto with reference to keikyososooshinbuto, for patients feeling cold, by means of multiple regression analysis.
Case reports : We reported a patient with an upset stomach whose severe coldness was improved as the stomach condition was cured by adding keishito to maobushisaishinto. Moreover, the combination of keishito and maobushisaishinto was effective for a patient feeling cold, with appetite loss, general fatigue and stiffness of the joints (case 1), a patient feeling cold, with chill, general fatigue, heavy feeling in the stomach, and prone to catch colds (case 2), and a patient feeling extremely cold, with general fatigue and menstrual pain (case 3).
Subjects and Methods : In this study, the subjects were 43 patients who reported feeling cold. They were treated with keishito and maobushisaishinto according to their Sho for more than one month. The relationships between the improvement of cold sensation and 52 other factors, such as symptoms noted at their first medical examination, were evaluated by means of multi-dimensional cross-sectional analysis.
Results : The factors of chilly or unpleasant wind and coldness of the whole body were significant.
Discussion : The factors of coldness in the whole body with chill, and headache without diarrhea were important for improvement of cold feeling with keishito and maobushisaishinto.

In Kampo, “lung medicines” are usually used to treat patients with bronchial asthma, according to the type of cough and sputum, and the degree of dyspnea which presents. However, it is also important to exclude exacerbating factors. In Kampo, the lungs and large intestine are thought to have a close relationship. We report three bronchial asthma patients whose cough and dyspnea were ameliorated by improving bowel movements. We discuss the types of bronchial asthma patients who might be effectively treated by controlling their defecation. We suggest that, when patients with mild bronchial asthma who have not previously had trouble with their bowel movements complain of respiratory distress with abnormal bowel movement, it might be effective to apply “large intestine medicines” to relieve their respiratory problems. (122 words)
Asthma ; Respiratory ; Bowel action ; Defecation ; Cases

Introduction : We evaluated the efficacy of daisaikoto for patients with generalized fatigability or easy fatigability by multiple regression analysis.Subject and Methods : The subjects were fifty-three patients with generalized fatigability or easy fatigability, consisting of 6 males and 47 females, mean age 38 y/o (range 23-72), who were treated with daisaikoto according to Sho for more than one month. The relationships between the improvement of generalized fatigability or easy fatigability and 46 factors, including age, sex, height, body weight, hypertension and other symptoms noted at the first medical examination, were examined by multi-dimensional cross-sectional analysis.Results : The factors of sweating, hot flushes, sensation of something stuck in the throat, and feeling of fullness in the chest were significant. Improvement of objective tenderness on the sides of the abdomen and sweating formed the best subset of explanatory variables.Discussions : The sensation of something stuck in the throat and feeling of fullness of the chest often occur under Ki stagnation. The improvement rather than the existence of objective tenderness on the sides of the abdomen is assumed to be more important factor.

Only a few years have passed by since the national health insurance began to be applied to the KANPO treatments. In order to grasp the patients profile of KANPO treatments, 3, 156 patients who consulted Shibuya Clinic from the lst of December in 1981 through the 30th of November in 1982, were analyzed. As the result; (1) in the respect of sex-age distribution in number, middle-aged female were most frequent. (2) the classification of chief complaints associated with the sex-age distribution seemed to suggest that the symptoms might change by aging from those of the upper respiratory tract or the skin lesion to arthralgia or lumbago, from the surface to the deep, or from the upper to the lower part of the body. we also tried to compare the result with this kind of reports of the others.