Aside from myocardial infarction, coronary spastic angina, and air embolism of the coronary arteries, Takotsubo cardiomyopathy is a rare cause of ST elevation during the perioperative period of cardiovascular surgery. Here we report a case of Takotsubo cardiomyopathy that developed with ST elevation during total arch replacement. A 71-year-old man was found to have an abnormality on chest X-ray. A thoracic aortic aneurysm with a maximum diameter of 68 mm was diagnosed on CT, and surgical intervention was indicated. Preoperative ECG showed no abnormality. Transthoracic echocardiography showed normal left ventricular wall motion. No valvular disease was observed. Coronary angiography showed a 50% stenotic lesion in the right coronary artery, but it was not considered significant. Total arch replacement was performed under moderate hypothermic circulatory arrest with anterograde selective cerebral perfusion. After retrograde terminal warm blood cardioplegia and aortic declamping while removing air from the root cannula, ST elevation in the II, III, and chest leads was noted and transesophageal echo showed impaired left ventricular wall motion. However, the right ventricular wall motion appeared normal under direct vision. While cardiopulmonary bypass was maintained with total perfusion, the ST level gradually improved. He was weaned from cardiopulmonary bypass 62 min after aortic declamping. ST elevation was observed again during sternal closure, so the patient was taken to the cardiac catheterization room immediately after the operation. Coronary angiography showed no significant change from before surgery. Left ventriculography revealed hypokinesia of the apex, leading to a diagnosis of Takotsubo cardiomyopathy. Inotropic agents and coronary dilators were discontinued. After confirming the stability of hemodynamics and the improvement of ST elevation on ECG, the patient was extubated on the first day after surgery and left the intensive care unit on the third day. On the 15th day, he was discharged from the hospital. This case shows that, if the right ventricular wall motion is normal despite ST elevation in the II and III leads intraoperatively, Takotsubo cardiomyopathy is a potential cause of the left ventricular dysfunction that might be considered in the differential diagnosis.

Background and Purpose : Patients who undergo cardiac and thoracic vascular surgery are known to have a high risk of developing acute kidney injury (AKI). The incidence of post-operative acute renal failure and the utility of continuous hemodiafiltration (CHDF) for acute renal failure following cardiovascular surgery was determined. Subjects and Methods : Of the 321 subjects who underwent cardiac and thoracic vascular surgery accompanied by an open thoracotomy from January 2014 to August 2017, 303 patients were included in this study after excluding those who received maintenance dialysis and those treated with PCPS. Patients were grouped based on the GFR classification of CKD severity (preoperative eGFR values : G1 : ≥90, G2 : <90, G3a : <60, G3b : <45, G4 : <30, G5 : <15) and patient records were retrospectively examined. Results : The total incidence of AKI was 30.7%. In comparison with G1 and G2, the AKI incidence rate was significantly higher (p<0.01) in G3a, G3b, G4, and G5 patients who displayed preoperative renal dysfunction. Upon multivariate analysis, preoperative eGFR values were shown to be a predictor of post-operative AKI avoidance with a cutoff value of 56 ml/min/1.73 m2 (odds ratio = 4.104, AUC = 0.6954). The post-operative CHDF introduction rate was 3.6%. After introduction of CHDF, patient urine volume and body blood pressure significantly increased (p < 0.01). In 2 cases, a rapid increase of urine volume (2.5 ml/kg/h, 1.8 ml/kg/h) was observed within 1 h after the induction of CHDF. Conclusions : A high rate of post-operative AKI onset occurs in cardiac and thoracic surgery cases. Upon early introduction of post-operative CHDF, prompt recovery of renal function and stabilization of circulatory dynamics can be expected.

The case concerns a seventy-one-year old male patient on maintenance dialysis. He experienced chest discomfort and called for emergency conveyance. He was diagnosed with acute Stanford type A aortic dissection with open false lumen and expanded hematoma around the aorta using computed tomography (CT). The patient was referred to our hospital for emergent surgical intervention. At the time of admission to our hospital, cerebral hemorrhage in the left thalamus and right head of caudate nucleus was revealed on a CT head scan. On neurologic examination, a slight drop in exercise ability was demonstrated in the right arm. We shared the images offline with a neurosurgeon in a neighboring hospital. After the consultation, surgery for the acute aortic dissociation was canceled due to concerns about cerebral hemorrhage aggravation with the use of an intraoperative anticoagulant. Although there was no indication for surgical intervention for the cerebral hemorrhage at that point, he was placed under careful observation. Hemodialysis using nafamostat mesilate was restarted ; fortunately, there was no exacerbation in the cerebral hemorrhage. However, a CT scan revealed expansion of the false cavity of the ascending aorta on the fifth day post-diagnosis. After confirming no exacerbation of cerebral hemorrhage on CT on the fifth, sixth, and seventh days, graft replacement of the ascending aorta and concomitant aortic valve replacement for aortic valve stenosis were performed on the eighth day. He was extubated on the first postoperative day. He left the ICU on the sixth postoperative day. Neither increase of hematoma on the postoperative CT, nor any exacerbation of the neurologic symptoms was observed. On the forty-seventh postoperative day, he was shifted back to the referring hospital for rehabilitation.Acute aortic dissection with simultaneous onset of cerebral hemorrhage is very rare. Though both conditions are critical, there are no guidelines for treatment, and decisions on the treatment strategy are unclear. In this case of acute Stanford type A aortic dissection, there was a concern about the exacerbation of cerebral hemorrhage with the use of an intraoperative anticoagulant. We report the successful surgical repair of acute aortic dissection one week after onset as a viable therapeutic option in cases where emergency intervention is not possible due to associated complications.