1.Characteristics of Hemorrhagic Peptic Ulcers in Patients Receiving Antithrombotic/Nonsteroidal Antiinflammatory Drug Therapy.
Kazuhiko NAKAMURA ; Kazuya AKAHOSHI ; Toshiaki OCHIAI ; Keishi KOMORI ; Kazuhiro HARAGUCHI ; Munehiro TANAKA ; Norimoto NAKAMURA ; Yoshimasa TANAKA ; Kana KAKIGAO ; Haruei OGINO ; Eikichi IHARA ; Hirotada AKIHO ; Yasuaki MOTOMURA ; Teppei KABEMURA ; Naohiko HARADA ; Yoshiharu CHIJIIWA ; Tetsuhide ITO ; Ryoichi TAKAYANAGI
Gut and Liver 2012;6(4):423-426
BACKGROUND/AIMS: Antithrombotic/nonsteroidal antiinflammatory drug (NSAID) therapies increase the incidence of upper gastrointestinal bleeding. The features of hemorrhagic peptic ulcer disease in patients receiving antithrombotic/NSAID therapies were investigated. METHODS: We investigated the medical records of 485 consecutive patients who underwent esophagogastroduodenoscopy and were diagnosed with hemorrhagic gastroduodenal ulcers. The patients treated with antithrombotic agents/NSAIDs were categorized as the antithrombotic therapy (AT) group (n=213). The patients who were not treated with antithrombotics/NSAIDs were categorized as the control (C) group (n=263). The clinical characteristics were compared between the groups. RESULTS: The patients in the AT group were significantly older than those in the C group (p<0.0001). The hemoglobin levels before/without transfusion were significantly lower in the AT group (8.24+/-2.41 g/dL) than in the C group (9.44+/-2.95 g/dL) (p<0.0001). After adjusting for age, the difference in the hemoglobin levels between the two groups remained significant (p=0.0334). The transfusion rates were significantly higher in the AT group than in the C group (p=0.0002). However, the outcome of endoscopic hemostasis was similar in the AT and C groups. CONCLUSIONS: Patients with hemorrhagic peptic ulcers receiving antithrombotic/NSAID therapies were exposed to a greater risk of severe bleeding that required transfusion but were still treatable by endoscopy.
Anti-Inflammatory Agents, Non-Steroidal
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Endoscopy
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Endoscopy, Digestive System
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Hemoglobins
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Hemorrhage
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Hemostasis, Endoscopic
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Humans
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Incidence
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Medical Records
;
Peptic Ulcer
Result Analysis
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