After being stimulated by the application of electroacupuncture (EA) to “KOTAN” leg point (bilaterally), chickens became sedated and showed and showed analgesia with little response to skin clamping. Following the observation of M waves of Motor nerves and evoked responses of Sensory nerves, it was found that while efferent information was temporarily inhibited during EA stimulation, afferent information was depressed during EA and the effect continued for several hours after termination of EA. It is suggested that these phenomena may be controled by neurohumoral mechanisms.

We experienced a case of infantile hydrocele with operation indication successfully treated with therapy based on Kampo diagnosis. The case was 4 years-old boy who was advised about an operation with the diagnosis of left hydrocele. At first, goreisan extract was administered, which resulted in a reduction of his hydrocele. However, the condition had worsened after his entrance into preschool. So, we changed the formulation to shokenchuto extract, which resulted in the disappearance of the hydrocele. Up to now, there has been no recurrence. We suggest that it is worthwhile to treat infantile hydrocele patients with Kampo medicine for a certain period of time, if their family gives consent. Moreover, shokenchuto or similar formulations might be practicable for such hydrocele, in addition to formulae which regulate body fluids.
Medicine, Kampo ; Therapeutic procedure ; Diagnostic ; Treated with ; Infantile

We investigated prescriptions and drug costs at admission and discharge for 35 patients hospitalized in Department of Japanese Oriental (Kampo) Medicine, Chiba University Hospital from September 2006 to October 2008. They recovered after Kampo therapy from various non-acute diseases. The number of western drugs decreased from 3.7 at admission to 2.7 at discharge, thus their drug costs per day significantly decreased from302.1yen to 227.6 yen. The cost of Kampo medicines themselves, on the other hand, did not decrease significantly. Total drug costs, however, were significantly reduced from 437.8 yen at admission to 348.0 yen at discharge, so patients' overall costs were reduced by 20%. These results indicated that the proper use of Kampo medicine for various diseases would reduce drug costs and the impact of treatment expenses on medical economics, with improvement in disease outcomes.

We experienced a case of erythema nodosum of unknown etiology successfully treated with therapy based on Kampo diagnosis. The case was 44 year-old woman who had erythema nodosum over her bilateral leg extensors several times a month, became cold easily and had stomatitis. At first, we administered seinetsuhokito, which resulted in the disappearance of her stomatitis. However, she still had a recurrence of her erythema nodosum. Because of a condition of interior heat and qi counterflow, we considered her situation heibyo. We administered seinetsuhokito and byakkokakeishito every other day, which resulted in the disappearance of both her stomatitis and erythema nodosum. Therefore, we suggest that it is worthy to think about heibyo situations, when treating patients with complications.
Erythema Nodosum ; Stomatitis ; Treated with ; Medicine, Kampo ; month

Laryngeal granulomas which grow in the rear of the vocal cords can be a refractory and recurrent condition, because of various pathogeneses and a lack of established treatment guidelines. We experienced a laryngeal granuloma case which recurred repeatedly, and was resistant to modern medicinal treatment. The laryngeal granuloma recurred after microlaryngosurgery. And though a second microlaryngosurgery and laser cauterization was done, followed by prescription of lansoprazole, tranilast, chlarithromycin and inhalation of fluticasone propionate, the laryngeal granuloma recurred once more. Thus, we tried Kampo medicines at the this time. Hangekobokuto, saishakurikkunshito and keikyososooushimbuto were stopped due to lack of efficacy on the ganuloma, and the Kampo formulation was changed to kairosan. Three weeks after changing formulation, the granuloma was no longer seen with laryngeal fiberscopy. And to-date, recurrence of the granuloma has not been confirmed. This case suggests that fatigue, body weight loss, bilateral Kyokyo-kuman (discomfort of the hypochondrium), bilateral excessive strain of abdominal muscles, pulsation of both the upper and lower navel, and tympanitic sound in upper abdomen may be clinical indications for kairosan.
Granuloma ; recur ; Red color ; Granuloma, Laryngeal ; Medicine, Kampo

The source of reitakutsukito, which has been described in only one case, is the text “Ranshitsu-hizo.” We recently experienced a 65-year old male suffering from refractory chronic headache for forty years, and a 38-year old female suffering from bronchial asthma resistant to tokishigyakukagoshuyushokyoto, whose symptoms were successfully treated with reitakutsukito by adding shin'i which has the action of dispersing pathogenic wind factor and opening orifice. Although reduction of underlying disease was not obtained, we also experienced clear improvement of oxygen saturation peripherally, and the subjective symptoms of a 40-year old male suffering from bronchial amyloidosis with reitakutsukitokashin'i. We report these three cases including documented considerations.
Asthma ; Amyloidosis ; Cases ; Bronchial brand of guaifenesin-theophylline ; symptoms <1>

Wells' syndrome (eosinophilic cellulitis), whose etiology is idiopathic, is clinically characterized by solitary or multiple cellulitis-like eruptions which occur on the extremities and trunk. Corticosteroids are usually used for palliative treatment, but relapses are often observed. We observed an 8 year-old patient with Wells' syndrome successfully treated with Kampo medicines. In 2001, skin eruptions appeared on his extremities. In 2002, a histopathologic examination determined his disease to be Wells' syndrome, and corticosteroids were subsequently used for treatment. In January 2007, his skin eruptions worsened, and he first visited our outpatient clinic in May. After oral administration with keigairengyoto, his skin eruptions were slightly improved, but afterwards, they again worsened. In June, jumihaidokuto was administered instead of the former prescription, and the skin conditions had begun to improve. Because dry skin appeared in November, keigairengyoto was again added. With these treatments, his skin eruptions stably improved. In previous reports, Kampo medicines had not been used for the treatment of Wells' syndrome. This case, however, suggests that Kampo medicines are a candidate for the treatment of Wells' syndrome.

We experienced four cases of urticaria (two patients with cholinergic urticaria, one patient with chronic idiopathic urticaria and one patient with cold urticaria) successfully treated with Kampo therapy. The factors for outbreak or aggravation of urticaria were stress of looking after the father in law and hysterectomy in the first case, psychological stress due to familial trouble in the second case, panic disorder like episode in the third case, and solicitude and anxiety for family in the fourth case. The effective Kampo formulae that improved the dermatological symptom were keishibukuryogan, hangekobokuto, yokukansankachimpihange and kamishoyosan, respectively. It was helpful that to clarify the psychological background affecting the dermatological symptom in the determination of Kampo formulae. It would be useful that careful and repetitious question and answer about psychological background in the treatment of intractable urticaria.

The source of Jiinshihoto, which has been used for patients troubled by chronic cough with Ki obstruction, is Wanbinhuichun. We report on 8 cases with various chronic inflammatory diseases in the airway successfully treated with Jiinshihoto. They had similar symptoms, i. e., chronic coughing both dry and moist, and the abnormal sensations in the throat. Our experience with these cases suggests that tympanitic sound on right half side of the abdomen increase the accuracy of Jiinshihoto usage.

We report on 3 patients who presented with symptoms of Ki obstruction, Ki deficiency, and disorder of the body's fluid metabolism, successfully treated with bukuryoingohangekobokuto. In our experience, bukuryoingohangekobokuto has been effective in 25 of the 30 patients (6 men and 24 women) to whom is has been administered, who also presented with Ki obstructions, Ki deficiencies and disorders of the body's fluid metabolism as mentioned above. The most common subjective symptom in all these effectively-treated patients was hot flashes. Other signs were epigastric pain or discomfort accompanied by chest signs and symptoms, such as palpitations, heartburn, chest oppression or dyspnea. The most common objective findings in these effectively-treated patients were pulsation at the pit of the stomach and navel, and a fluid sound in the stomach upon palpation. Based on our experiences, we believe that prescription of bukuryoingohangekobokuto is best indicated when the presence of the above-mentioned symptoms and findings has been confirmed.
symptoms <1> ; Liquid substance ; Cases ; seconds ; findings