1.Experimental Study for the Effects of Free Physeal Transplantation to Regain Bone Grwoth after Partial Physeal Injury
Kwang Zin RHEE ; Sang Yeon RHA ; Kap Yop LEE
The Journal of the Korean Orthopaedic Association 1985;20(5):743-752
This study is performed to investigate whether free transplanted iliac physis can grow in the resected epiphyseal plate and prevent growth arrest secondary to an injury of epiphyseal plate. Growth arrest, angulation and regeneration of epiphyseal plate after free physeal transplantation from iliac crest in the partial resection of epiphyseal plate on the lateral aspect of the distal femoral epiphysis were analysed in process of time and compared with those of the simple partial resection of epiphyseal plate of distal femur. Seventy-six skeletally immature, three month-old rabbits with an initial weight of about 1200 to 1400gm were used for this study. The following experimental groups were made after partial resection of epiphyseal plate on lateral aspect of distal femoral epiphysis(2×7×3mm). Group A: partial resection alone(19 rabbits); Group B: muscle piece interposition(19 rabbits); Group C: free autogenous iliac crest physeal transplantation (38 rabbits). The opposite side of the leg was used as a control. Animals were killed and examined at the following time-intervals(14, 21, 30, 60 and 90 days after operation). The following results were obtained. 1. In the group of partial resections alone, the bone-brige formation between the femoral epiphysis and metaphysis revealed as early as 14 days, and this bridging was found consistently in all anlmals, which led to the growth arrest and valgus deformity. 2. In the group of muscle piece interpositions, the interposition materials were found temporarily effective for the prevention of epiphysiometaphyseal bone-bridge formation, but the effect was not significant to regain bone growth. 3. Histological studies showed that the grafted physis united with the residual part of the original femoral physis at 14 days after transplantation, and regained its columnar arrangement. The physeal graft appeared to be viable and contribute endochondral bone formation in following section (60, 90 days). 4. In the grodp of free autogenous iliaccrest physeal transplantations, the transplanted physis prevented or minimized the formation of a bone brige, growth arrest, and valgus deformity in most animals. Although not all of the physeal transplants were successful, physeal grafts would be most suceessful method regaining bone growth after focal injury of epiphyseal plate.
Animals
;
Bone Development
;
Congenital Abnormalities
;
Epiphyses
;
Femur
;
Growth Plate
;
Leg
;
Methods
;
Osteogenesis
;
Rabbits
;
Regeneration
;
Transplants
2.Pure Epithelioid Malignant Schwanoma: A case report.
Hye Yeon KIM ; Kyu Bum LEE ; In Sun KIM ; Kap No LEE ; Seung Yong PAIK
Korean Journal of Pathology 1986;20(4):496-502
The pure epithelioid malignant schwanoma is a rare form of malignant schwanoma and differs from the ordinary epithelioid malignant schwanoma because of the absence of a spindle cell component. We present a case of purely epithelioid malignant schwanoma arising in the parapharyngeal area from vagus nerve without difinite evidence of von Recklinghausen's disease. The patient was a 28-year-old man with palpable right neck mass and swallowing difficulty during 2 years. The mass was an ovoid encapsulated tumor and measured 5x3x3 cm in dimension. The cut surface showed brownish tan homogeneous nodular appearance with partly myxoid area. Microscopically the tumor showed nodular pattern composed of epitheliod cells which were arranged in both tight clusters and stringy cords. The cells were ovoid in shape and had vesicular nuclei with single prominent eosinophilic nucleolei and sometimes abundant intracytoplasmic mucin. Mitoses were infrequent. Ultrastructural study showed rudimentary cell junction and degenerated cytoplasmic organelles including scattered mitochondriae, short segments of rough endoplasmic reticulum and lipid droplets. There were no definite basement membrane and melanosome. Immunohistochemical study showed the cells being positive for S100 protein, neuron specific enolase and myelin basic protein and negative for cytokeratin.
Male
;
Humans
3.Gastrointestinal Tumors Associated with von Recklinghausen's Neurofibromatosis: A report of two cases.
Mee Ja PARK ; Hye Yeon KIM ; Nam Hee WON ; In Sun KIM ; Kap No LEE ; Seung Yong PAIK
Korean Journal of Pathology 1985;19(3):345-349
Neurofibromatosis, first clearly described by von Recklinghausen in 1882, is a dominantly inherited mesodermal and ectodermal dysplasia with a broad spectrum of clinical findings. Most common is the classical neurofibromatosis, which has three major features: (1) multiple neural tumors dispersed anywhere on or in the body; (2) numerous pigmented skin lesions, some of which are "cafe au lait" spots; and (3) pigmented iris hamartomas also called Lisch nodules. Other lesions sometimes seen in patients with von Recklinghausen's disease include congenital malformations of various types, vascular lesions, neurilemoma meningioma and other intracranial neoplasms, pheochromocytoma, medullary carcinoma of thyroid gland, neuroblastoma, ganglioneuroma and Wilms' tumor. Approximately 10% of the patients with neurofibromatosis have the gastrointestinal tract tumors as neurofibroma, ganglioneuroma and leiomyoma. Some of them show evidence of malignancy. Increased activity of the protein "nerve growth factor" in the sera of the patients with disseminated neurofibromatosis has been reported. We would like to report here two cases of von Recklinghausen's neurofibromatosis with involvement of the gastrointestinal tract.
Hamartoma
;
Meningioma
4.Endometrial Carcinoma Associated with Stein-Leventhal Syndrome: Two cases report.
Hye Yeon KIM ; Insun KIM ; Hye Rim PARK ; Kap No LEE ; Seung Yong PAIK
Korean Journal of Pathology 1986;20(3):374-377
Stein-Leventhal syndrome is a clinicopathological entity characterized by chronic anovulation and sclerotic ovaries. Clinically, the affected patients typically present their third decade with a history of premenarchal obesity and postmenarchal onset of oligomenorrhea or amenorrhea, infertility, and clinical evidence of increased androgen production. In some patients, there are estrogenic phenomena such as menometrorrhagia with or without endometrial hyperplasia or carcinoma. Several studies have indicated that there may be an increased incidence of ovarian neoplasia in polycystic ovaries. Recently, we experienced two cases of polycystic ovaries assotiated with endometrial carcinoma in premenopausal women, who had clinical characteristics of Stein-Leventhal syndrome; one of the cases had additional serous cystandenofibroma.
Female
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Humans
;
Incidence
5.Sturge-Weber Syndrome: Report of an incomplete form.
Hye Yeon KIM ; Kap No LEE ; Seung Young PAIK ; Ki Chan LEE ; Chang Soo LIM ; Suck Ho NAM ; Je G CHI
Korean Journal of Pathology 1985;19(2):226-230
The Sturge Weber syndrome is an uncommon disorder characterized by port-wine nevus of the face with angiomatosis of the ipsilateral cerebral leptomeninges and extensive calcification in the underlying cerebral cortex. Associated with this syndrome are mental retardation, choroidal angioma, buphthalmus or glaucoma, seizure and hemiplegia. We studied a case of incomplete form of Sturage Weber syndrome in a 12 year-old boy, who had generalized seizure, a homonymous hemianopsia, intracranial calcification and leptomeningeal angiomatosis. There are no characteristic facial nevus, mental retardation, occular changes and hemiplegia.
6.Structure and Function Analysis of alpha-MSH Analogues.
Sung Kil LIM ; Song Chul LEE ; Won Tae LEE ; Jung Hoon LEE ; Soo Yeon NAM ; Kyung Rae KIM ; Hyun Chul LEE ; Kap Bum HUH
Journal of Korean Society of Endocrinology 1999;14(1):18-26
No abstract available.
alpha-MSH*
;
Obesity
7.A Study Food Habits, Food Behaviors and Nutrition Knowledge among Obese Children in Changwon (I).
Eun Sil HER ; Kyung Hea LEE ; Dong Su JANG ; Kap Yeon LEE ; Ju Hee LEE ; Jeong JU ; Sang Yeun YOON
Journal of the Korean Dietetic Association 1999;5(2):153-163
The purpose of this study was to obtain basic data of nutrition education for obese children and to examine food habits, food behaviors, and nutrition knowledge. A convenience sample of 84(male:62, female:22) obese children was selected from "98 Children Nutrition Camp". The survey design employed a structured questionnaire. The results of this study were summarized as follows. 1. The percentage of the subjects who overestimated their body weight was higher in female compared to male. Only 35.9% of highly-obese subjects considered them as 'very fat'. The experience of weight control was higher in female than in male, and it was also higher moderately- or highly-obese subjects compared to mildly obese. 2. 64.3% of subjects reported that they regularly eat breakfast. The percentage of the subjects who indicated that they eat at regular meal time or they eat very irregularly was highest in the highly-obese subjects. 3. 34.5% of subjects reported that they eat very fast. The eating speed was slower in female compared to male, and in obese subjects. 55.4% of subjects reported that didn't eating out. 4. 80.9% of subjects had snacks, and most of them had snack between lunch and dinner. The reason the subjects eat snack was hunger. The most favorite snack was cookies. 5. The most preferred and distasteful food was meats(32.1%) and vegetables(67.1%), respectively. 6. The score of food behaviors was relatively low in most subjects. 7. The level of nutrition knowledge was in order of fair(83.1%), poor(9.6%), excellent(7.3%), and was higher in male compared to female. Consequently the results of this study showed to disagreement among food habits, food behaviors and nutrition knowledge, and feel keenly the necessity of education connecting of these. This education had to be practical education to change food behaviors.
Body Weight
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Breakfast
;
Child*
;
Eating
;
Education
;
Female
;
Food Habits*
;
Gyeongsangnam-do*
;
Humans
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Hunger
;
Lunch
;
Male
;
Meals
;
Surveys and Questionnaires
;
Snacks
8.A Case of Dup (3q) Syndrome.
Yo Seop PAHN ; Mi Yeon CHOI ; Young Ah LEE ; Woo Kap CHUNG ; Keun Young LEE ; Sook Kyoung OH
Journal of the Korean Pediatric Society 1997;40(3):408-412
We have experienced a case of dup (3q) syndrome in the neonate who had a multiple congenital anomalies of hypertrichosis, hypertelorism, upslanting palpaberal fissures, anteverted nostrils, long philtrum, micrognathia, downturned corners of the mouth, highly arched palate, short, webbed neck, clinodactyly, rocker-bottom feet, dermal sinus. Cytogenetic studies showed a duplication 3q21-->qter regions. Chromosome study of relatives is extremely important for counseling because only 25% of cases represented de novo duplications. We reported the case with the review of the associated literatures.
Counseling
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Cytogenetics
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Foot
;
Humans
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Hypertelorism
;
Hypertrichosis
;
Infant, Newborn
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Lip
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Mouth
;
Neck
;
Palate
;
Spina Bifida Occulta
9.A Clinical Study of Single Umbilical Artery.
Mi Yeon CHOI ; Young Jun KIM ; Young Ah LEE ; Ha Joo CHOI ; Woo Kap CHUNG ; Keun Young LEE
Journal of the Korean Pediatric Society 1998;41(4):498-504
PURPOSE: Single umbilical artery (SUA), the most common malformation of the umbilical cord, has long been of interest because of its association with congenital malformations. This retrospective study was aimed to evaluate the incidence of SUA and its associated malformations. METHOD: The study population was inborn neonates of Kang-Nam Sacred Heart Hospital of Hallym University. We reviewed retrospectively the medical records of 15 infants with SUA, including 1 infant identified in prenatal ultrasonography. RESULTS: The incidence of SUA was 0.2% (15/9,351 cases). The mean birth weight was 2,658 gram (ranged from 1,060 to 3,700gram), and the mean gestational age was 38 weeks (ranged from 32 to 40 + 3weeks). Six cases (40%) of 15 cases with SUA were associated with congenital malformations : urogenital malformations in 4 cases, cardiovascular malformations in 3 cases, and musculoskeletal malformations in 3 cases. Only 1 case had abmormal karyotype, trisomy 18. CONCLUSION: Because SUA is highly associated with congenital malformations newborns with SUA should have a thorough and complete physical examination at birth and physicians should also be alert to the possibility of congenital malformations not evident at initial examination. Furthermore, prenatal detection of SUA has potential importance, since it may indicate that further work is necessary to rule out associated malformations and to help determine whether management should beltered.
Birth Weight
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Gestational Age
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Heart
;
Humans
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Incidence
;
Infant
;
Infant, Newborn
;
Karyotype
;
Medical Records
;
Parturition
;
Physical Examination
;
Retrospective Studies
;
Single Umbilical Artery*
;
Trisomy
;
Ultrasonography, Prenatal
;
Umbilical Cord
10.The Benificial Effects of Growth Hormone Therapy with Diet Restriction in Obese Adults.
Sung Kil LIM ; Bong Soo CHA ; Young Duk SONG ; Hyun Chul LEE ; Kap Bum HUH ; Eun Sook KIM ; Jae Ho SHIN ; Kyung Rae KIM ; Soo Yeon NAM
Journal of Korean Society of Endocrinology 1997;12(4):571-583
BACKGROUND: Carolic restriction as a treatment for obesity causes catabolism of body protein stores and produces negative nitrogen balance. GH administration causes acceleration of lipolysis and promotion of nitrogen conservation. We evaluated the effects of GH treatment and caloric restriction on lipolysis, anabolic effects and body composition in obese subjects. METHODS: 24 obese (20% over IBW) subjects (22 women and 2 men; 22-46yr old) were fed a diet of 25kcal/kg IBW with 1.2g protein/kg IBW daily during treatment. The subjects were assigned at random to either treatment with recombinent human GH (n=12, 0.06U/kg IBW every other day) or placebo (n 12, vehicle injection) for 12 weeks. Body fat was assessed by impedence and abdominal fat, visceral fat area at the umbilicus level and muscle area of mid thigh level were measured using computed tomography. RESULTS: Fraction of body weight lost as fat lost was significantly greater in GH treatment than in placebo group (1.21+-0.48%/kg, vs 0.52+-0.28%/kg, p0.05). GH treatment caused significant decrease in visceral fat area (35.3% vs 28.5%, p<0.05). In placebo group, there were significant loss of muscle area (-4.8 +-2.6cm ) and lean body mass (-2.62 +-1.51kg) after treatment. In contrast, GH treatment group had more increase in muscle area (3.5+-2.3cm ) and lean body mass (1.13 +-1.04kg) and positive nitrogen balance (1.81+-4.06g/day). GH injections cuased a 1.6-fold increase in IGF-I, despite caloric restriction. GH responses to L-dopa stimulation were blunted in all subjects and GH responses were increased after treatment. Both group showed hyperinsulinemia during oral glucose tolerance test (OGTT), and after treatment, they had decreased in insulin secretion. However, GH treatmnent group had not significant decrease, because GH might induce insulin resistance. FFA response areas during OGTT markedly decreased after treatment in both group. In GH treatment group, more decrease of FFA responses might result from the antilipolytic effect by higher level of insulin or more decrease in amount of fat. CONCLUSION: This study has demonstrated that in obese subjects fed hypocaloric diet, GH accelerates body fat loss and exerts anabolic effects.
Abdominal Fat
;
Acceleration
;
Adipose Tissue
;
Adult*
;
Anabolic Agents
;
Body Composition
;
Body Weight
;
Caloric Restriction
;
Diet*
;
Female
;
Glucose Tolerance Test
;
Growth Hormone*
;
Humans
;
Hyperinsulinism
;
Insulin
;
Insulin Resistance
;
Insulin-Like Growth Factor I
;
Intra-Abdominal Fat
;
Levodopa
;
Lipolysis
;
Male
;
Metabolism
;
Nitrogen
;
Obesity
;
Thigh
;
Umbilicus