No abstract available.
Epidermolysis Bullosa* ; Hand Deformities* ; Hand*

BACKGROUND: The insulin resistance is common in the patients with essential hypertension, even in the absence of non-insulin-dependent diabetes mellitus(NIDDM) or hyperlipidemia. It is well known that the offspring of patients with NIDDM have shown less insulin sensitivity compared with that of normal parents. But it is not yet known whether the insulin resistance is common in the offspring of patients with essential hypertension in Korea, who have no hypertension, NIDDM and hyperlipidemia. The aims of this study were to find out whether the insulin resistance exist in the middle aged normal offspring of the patients with essential hypertension and whether the insulin resistance is dependent on the metabolic abnormalities such as the body mass index(BMI), obesity and hyperlipidemia. METHODS: The serum lipid profiles and oral glucose tolerance test were performed. The anthropometrical measurement was done. The abdominal CT scan at umbilicus level and thigh CT was performed in the 11 offspring of parents with essential hypertension(group I;male : 7, female : 4)and 24 offspring of parents without essential hypertension, NIDDM, ischemic heart disease and hyperlipidemia(group II; male : 9, female : 15). RESULTS: The average age of group I was 44.1+/-6.9 years, and that of the group II was 47.5+/-9.5 years. There were no significant differences in the blood pressure, weight, BMI, waist to hip ratio, waist to thigh ratio. And there were no significant differences in the serum cholesterol, triglyceride, HDL-cholesterol, serum Na, and plasma renin activities between both groups. Fasting plasma insulin and 2 hour insulin after 75gm glucose ingestion were significantly higher in group I than in group II(8.5+/-3.0mU/mL versus 5.0+/-1.8mU/mL, 61.6+/-31.7mU/mL versus 33.3+/-16.8mU/mL, p<0.05). The insulin sensitivity index was significantly lower in group I than in group II(355.1+/-92.6 versus 451.8+/-88.1, p<0.05). The visceral fat area was wider in group I than in group II(102.0+/-30.7cm2 versus 64.5+/-28.5cm2, p<0.05). The multiple regression analysis with the fasting plasma insulin and insulin sensitivity index as the dependent variables and family history of essential hypertension, visceral fat area and BMI as the predictor variables revealed that only the family history was associated with the fasting plasma insulin and insulin sensitivity index. CONCLUSIONS: The offspring of the parents with essential hypertension showed the insulin resistance with increased visceral fat area in comparison with the offspring of the parents without essential hypertension.
Blood Pressure ; Cholesterol ; Diabetes Mellitus, Type 2 ; Eating ; Fasting ; Female ; Glucose ; Glucose Tolerance Test ; Humans ; Hyperlipidemias ; Hypertension ; Insulin Resistance* ; Insulin* ; Intra-Abdominal Fat ; Korea* ; Male ; Middle Aged* ; Myocardial Ischemia ; Obesity ; Parents* ; Plasma ; Renin ; Thigh ; Tomography, X-Ray Computed ; Triglycerides ; Umbilicus ; Waist-Hip Ratio

BACKGROUNDS: The Rh antigens are important m clinical practice. The classification of Rh phenotype is usually based on the antigen detection done by conventional serologic method, but it has many limitation such as delicate grading of antigen expression. Recently, Flowcytometry has been introduced in immunohematology to detect and quantitate cell bound immunoglobulins to assess blood cell antigens and related antibodies. So, we tried these method to detect Rh(D) antigen and measure its density and evaluated the possibility of clinical usage. MATERIALS AND METHODS: We performed a flowcytometric analysis for the expression of D antigen in D-positive, negative and weak D group in indirect immune fluorescence assay by using polyclonal antibodies. We measured the intensity of immunofluorescence as a degree of antigen density and analysed the difference of mean channel fluorescence value(MCF) among these groups. RESULTS: Weak D groups had the lower fluorescence than D-positive group, while D-negative sample showed the same fluorecence as negative ntrol. The difference of fluorescence intensity of D antigen between that of C antigen were not observed and were statistically insignificant. CONCLUSION: Flowcytometry appear to be a good tool for antigen density measurement in immunohematologic areas and shows the possibility of application to other aspect.
Antibodies ; Blood Cells ; Classification ; Fluorescence ; Fluorescent Antibody Technique ; Immunoglobulins ; Phenotype

The exact analysis of urinary stones is very important to the study of the etiology of stone formation, prevention of recurrence and medical treatment. We Have analyzed 260 urinary stones obtained form 260 patients by X-ray diffraction method and studied the relationships of stone compositions to stone sites, patient age, sex and stone weight. The following results were obtained : 1. In this study 7 crystalline compositions of urinary stones were observed : Calcium oxalate monohydrate, Calcium oxalate dihydrate, Magnesium ammonium phosphate, Calcium magnesium phosphate, calcium phosphate, Uric acid and cystine. 2. Single composition stones were slightly more in number than mixed composition stones. Of 260 stones, 192(74%) were mainly composed of calcium oxalate, 38(14.4%) of magnesium ammonium phosphate, 19(7.3%) of calcium oxalate and calcium phosphate, 10(3.9%) of uric acid and 1(0.4%) of cystine. 3. Calcium oxalate stones was the most common of all the urinary stones and that comprised 80.7%(96) of all renal stones, 93.5%(86) of all ureteral stones, 46.2%(18) of all bladder stones and 100%(9) of all urethral stones. 4. Of 181 patients, ranged 30 to 59 years old who comprised 70% of all patients, 149(82.3 % of 181 patients) had calcium oxalate stones. 5. The ratio of the occurrence of magnesium ammonium phosphate to all renal or bladder stones from females was higher than that from males. 6 Of 27 stones weighed more than 10gm, 14(52%) were mainly composed of magnesium ammonium phosphate, and 10(37%) of calcium oxalate.
Ammonium Compounds ; Calcium ; Calcium Oxalate ; Crystallins ; Cystine ; Female ; Humans ; Magnesium ; Male ; Middle Aged ; Recurrence ; Ureter ; Uric Acid ; Urinary Bladder Calculi ; Urinary Calculi* ; X-Ray Diffraction

The basic technique for total reconstruction of the microtia was established by Tanzer, who utilized autologous rib cartilages for constructing the auricular framework. In order to decrease the number of surgical stages and to achieve maximal convolution, we employed a surgical procedure with simultaneous three layered costal cartilage grafting for the high profiled auricle, concha formation and lobule rotation. However, we performed ear elevation as an additional procedure for some patients who had decreased helical height due to absorption of cartilage framework or postoperative trauma and who had wanted to wear the spectacles or to have more natural appearance of auriculocephalic sulcus. From August 1988 to October 1997 we had performed surgeries for the ear elevation of 58 patients in 177 patients with total ear reconstruction, using various elevation methods; skin graft, local flap, and local with costal cartilage block. When the ear elevation was performed with skin graft, postoperative contraction of the grafted skin was inevitable. In cases with two skin flaps, it was difficult to stabilize and maintain the correct projection of the constructed ear. So we elevated the reconstructed ear by utilizing a costal cartilage block, two skin flaps to cover the posterior region and skin graft. We conclude that the local flap with costal cartilage block is one of the most favorable methods in ear elevation which can maintain the adequate projection and make natural looking auriculocephalic sulcus.
Absorption ; Cartilage ; Ear* ; Eyeglasses ; Humans ; Ribs ; Skin ; Transplants

Renal cell carcinoma in children is extremely rare as compared with Wilms` tumor. A case of renal cell carcinoma in an 8-year-old boy is presented with a brief review of literature.
Carcinoma, Renal Cell* ; Child ; Humans ; Male

We have studied 20 neurosurgical patients who had clear consciousness with Thalamonal- N2O-O2 anesthesia. Induction of anesthesia consisted of the intravenous injection of Thalamonal (one ml injection of Thalamonal at one to two minute intervals), and administration of N2O-O2 (4: 2 L/min) in a semiclosed circle absorber system, and maintaining anesthesia with intermittent injections of Thalamonal and N2O-O2 (2:1 L/min) inhalation. At the end of operation, we observed the change of respiratoty parameters after reversal of Thalamonal effect with nalorphine by Wright spirometer. The results were as follows; 1) Average induction dose of Thalamonal was l. 23 ml/10 kg, and average dose of Thalamonal for maintenance of anesthesia was 0. 125 ml/10 kg/30 min. (mean anesthetic time: 3 hours 29 minutes) 2) During induction, change of blood pressure was significant (P<0.05), and change of pulse rate was insignificant (P>0.05). 3) Woody chest (4 cases among 20) and hypotension (1 case among 20) were observed during induction. 4) After reversal of Thalamonal effect with nalorphine, changes of respiratory rate (P <0. 01) and minute volume (P <0. 05) were significant, but change of tidal volume was insignificant (P>0.05) 5) After discontinuation of N2O, seventeen cases among 20 recovered promptly, and the recovery was delayed in the remainder. Most delayed case recovered about 6 hours after the end of operation was due to overdose. Therefore Thalamonal is a suitable anesthetic agent for neurosurgical patients.
Anesthesia* ; Blood Pressure ; Consciousness ; Heart Rate ; Humans ; Hypotension ; Inhalation ; Injections, Intravenous ; Nalorphine ; Respiratory Rate ; Thorax ; Tidal Volume

No abstract available.
Anaphylaxis* ; Immunoglobulin G*

Tanzer reported microtia reconstruction using autogenous costal cartilage, thereafter so many plastic surgeons have tried various modification to get further refinement of reconstructed auricle. But the multiple stages of ear reconstruction required prolonged hospitalization and cost. In order to decrease the number of surgical stages and for the maximal convolution, we have employed a surgical procedure with three layered costal cartilage graft for the high profile auricle, concha formation and lobule transposition at the same time. However, it has still been difficult to reconstruct the tragus in cases of microtia that lack such component. We reconstructed the tragus using part of the microtic ear in addition to our above procedure simultaneously. This procedure is started with transposition of the lower two-thirds of the microtic ear to make lobule and then the upper third of the microtic ear is elevated as a chondrocutanenous flap which is then transposed 120-180degree C downwards to reposition at the area anterior to the conchal cavity. Using this technique, we have reconstructed 28 microtic ears. Adequate positioning of the auricle and tragus have been achieved and a more natural auricle obtained.
Cartilage ; Ear ; Hospitalization ; Transplants

No abstract available.
Thyroglobulin* ; Thyroid Gland*