No abstract available.
Korea*

No abstract available.
Korea*

No abstract available.
Korea*

No abstract available.
DNA Nucleotidylexotransferase*

We analyzed the predonation tests and the characteristics of plateletpheresis of the candidates and donors during 18 month at Korea University Guro Hospital from 1993 to 1995. Among the 810 candidates tested for predonation tests, 115(14.2%) candidates were deferred due to incompatible factors. The most common incompatible factor is elevated alanine aminotransferase(4.6%, ALT > 64 Iu) followed by incompatible ABO discrepancy (4.1%), positive HBsAg(3.3%), low platelet count(2.2%). 43.1 percent of the platelet donation candidates were processed plateletpheresis. 43(18%) of prospectively reviewed 240 plateletpheresis donors were relatives of the recipients. The percent of redonation was only 14% and its mean interval was 11.4 days. The result showed the plateletpheresis candidates have the relatively safety compared to that of the directed donation, social support of plateletpheresis donation program is strongly needed because of low redonation rate and characteristics of plateletpheresis donation.
Alanine ; Blood Platelets ; Directed Tissue Donation ; Fibrinogen ; Humans ; Korea ; Plateletpheresis* ; Prospective Studies ; Tissue Donors*

BACKGROUND: Korea university Gyro Hospital has run the KULAB system successfully since 1985, the increasing amount of hospital information made us the need for new system with larger capacity. We began to transform the KULAB, LIS only to the wly developed KUMNET-LAB, OCS system and we report our experience. METHODS: We used 5290 (Sequent, USA) with main memory of 128 megabyte and hard disk of 6.3 gigabyte as main completer, ORAGLE 7.2 (Oracle, USA) as database, fifteen 486 PCs, eight printers and seven barcode printers in the laboratory. A LAN was built. Pro-C was used in interface between the outpatient cashier and LIS. The Power builder (PentaKorea, USA) and Forms (Oracle, USA) and visual basic were used in interface between LIS and autoanalyzer. It took one month to analyse laboratory work flow and 2 months to programming by 2 programmers from the commercial vendor, ICM (Information & Communication Management Inc.). All laboratorian had taken part in job analyses and evaluations. RESULTS: Our laboratory information system was successfuly implemented without any major problem. The specimen type and emergency status were added to the test code. And the field indicating the sequential position on screen was added to the master to control the position of the test codes on screen. Bar code system was introduced to ample identification as well as specifically assigned specimen number. CONCLUSION: The KULAB system had been used from 1985 through 1995 was successfully transfered to the more efficient new LIS, KUMNET-LAB which is one of the basis of the OCS system (KUMNET).
Automatic Data Processing ; Clinical Laboratory Information Systems ; Commerce ; Emergencies ; Humans ; Korea* ; Local Area Networks ; Memory ; Outpatients ; Workflow

This pathology laboratory data management system is developed at the department of pathology and laboratory medicine, College of Medicine, Korea University, as an extension of Korea University laboratory Data managment and communication system. This is built in hospital computer for business, with the connection to the hospital business information system by software. The pathology department is only using terminals and printers, which enables us to maintain the lowest cost to maintain and operate the system. It has been written in COBO1 and utilized TOTAL Data Base and SNOMED (microglossary for surgical pathology). The input keys include patient hospital registration number, laboratory test code and SNOMED code or direct English written diagnostic words through dual masters of SNOMED.

OBJECTIVE: A cytogenetic survey of the mentally retarded children in Seoul City Welfare Center for the Mentally Retarded and St Peter school has been undertaken. METHODS: The chromosome analysis was carried out in 92 males and in 66 females as a total of 158 cases. RESULTS: Abnormal karyotypes were observed in 22.2% of the total cases (35/158). Autosome and sex chromosome anomaly were observed in 20.3%(32/158) and 1.9%(3/158) respectively. Of 35 cases of anomaly, 91.4%(32/35) was autosome anomaly and 8.6%(3/35), sex chromosome anomaly. CONCLUSION: Down syndrome karyotype was the most frequent anomaly among autosome anomalies which was 62.5%(20/32) and other autosome anomalies were observed in 37.5%(12/32).
Abnormal Karyotype ; Child* ; Cytogenetics* ; Down Syndrome ; Female ; Humans ; Karyotype ; Male ; Mentally Disabled Persons* ; Seoul ; Sex Chromosomes

In 41 cases of breast cancers, the aneuploidy measured by Image Analyzer was compared with that of flow cytometric analysis, and estrogen and progesterone receptor(ER/PR) and Her-2/neu oncoprotein were immunohistochemically stained and measured by Image Analyzer. In ER/PR, the positive nuclear area(PNA, %) was measured, and in Her-2/neu, the content of oncoprotein was expressed as pg/cell. To assess the usefulness of these parameters as a prognostic factor, the author evaluated the results in relation with tumor size, nuclear grade and lymph node metastasis. The obtained results are summarized as follows: 1) The detection rate (90%) of aneuploidy by image analysis was higher than that (70%) of flow cytometric analysis. The concordance rate of both method was 80%. 2) The positivity of ER was 73% and PR was 34%, and the high PNA of ER and PR was related with high nuclear grade. There was an inverse correlation of the ER PNA with tumor size and PR PNA with negative lymph node. 3) Her-2/neu oncoprotein overexpression was found in only 2 cases and another two showed borderline overexpression. All four cases had DNA tetraploidy. From the above results, it was concluded that the image analyzer could be used in DNA analysis and in quantitation of immunostained ER/PR and Her-2/neu oncoprotein, providing the important information in the management of the breast cancer patients.
Breast Neoplasms

This study was conducted by the Dept. of Preventive Medicine, Kyung-Hee University, School of Medicine as a preliminay test for the effects of Fluorine Compounds to the Plants from April through August, 1971. Fluorine was measured with Zirconium-Alizarine method and the following findings could be obtained : 1. Most high densities (25.7pptm) was found around the industrial areas and lowest (19.3pptm) around residential sections in Seoul. 2. Average density of Fluorine in the atmosphere of Seoul City was 22.3 pptm which can damage such plants as Pine, Strawberry, Peach and Grapes. 3. Fluorine contests (22.3pptm) in Seoul area atmosphere of shows about 4 times more than that of Cincinnati, Ohio, U.S.A.
Air Pollutants* ; Atmosphere ; Fluorine Compounds* ; Fluorine* ; Fragaria ; Humans ; Ohio ; Preventive Medicine ; Prunus persica ; Seoul ; Vitis