Objective To study the change and significance of bilateral frontal magnetic resonance spectroscopy (1H-MRS) in patients with Parkinson's disease depression (DPD).Methods 1H-MRS for bilateral frontal lobe was performed in 20 patients with DPD,23 patients with PD and 20 healthy controls.The metabolite ratios of N-acetylaspartate (NAA)/Creatine(Cr) and Choline (Cho)/Cr in patients with PD and DPD and control group were compared.Results The NAA/Cr values of the first frontal lobe of patients with DPD were significantly lower than those of PD patients (P<0.05),while Cho/Cr values were significantly higher than those of PD patients (P<0.05).There were no significant differences of NAA/Cr and Cho/Cr values between DPD and PD patients.Conclusion 1H-MRS can detect the metabolic changes of frontal lobe in patients with DPD,and it can contribute to the diagnosis and risk prediction of DPD.

Objective To study the change and significance of bilateral frontal magnetic resonance spectroscopy (1H-MRS) in patients with Parkinson's disease depression (DPD).Methods 1H-MRS for bilateral frontal lobe was performed in 20 patients with DPD,23 patients with PD and 20 healthy controls.The metabolite ratios of N-acetylaspartate (NAA)/Creatine(Cr) and Choline (Cho)/Cr in patients with PD and DPD and control group were compared.Results The NAA/Cr values of the first frontal lobe of patients with DPD were significantly lower than those of PD patients (P<0.05),while Cho/Cr values were significantly higher than those of PD patients (P<0.05).There were no significant differences of NAA/Cr and Cho/Cr values between DPD and PD patients.Conclusion 1H-MRS can detect the metabolic changes of frontal lobe in patients with DPD,and it can contribute to the diagnosis and risk prediction of DPD.