Objective To assess the accuracy of clinical criteria for assessing coronary artery recanalization after intravenous thrombolytic treatment.Methods Coronary angiography was performed to comparatively evaluate clinical parameters. One hundred patients were involved in this study.Results Clinical determinants showed a 70.6%sensitivity, 91.8% specificity and 81% predictive accuracy for coronary recanalization.Conclusion This result indicates that these clinical parameters are strongly correlated to the coronary angiography and are strongly predictive for patency of an infarct-related vessel. Of all these parameters, the early peak of cardiac enzymes levels had the highest specificity. T-wave inversion within one hour after thrombolytic therapy can be used alone as an earlier sign of coronary recanalization.