Objective This study aimed to investigate the clinical effect of long-snake moxibustion combined with modified Duhuo Jisheng Decoction in the treatment of the liver-kidney deficiency pattern of lumbar disc herniation. Methods All patients with liver-kidney deficiency pattern of lumbar disc herniation admitted to Nanchang Hongdu Hospital of Traditional Chinese Medicine from March 2021 to April 2023 were assigned the control group and the experimental group by random number table method,with 68 cases in each group. The control group was treated with conventional Western medicine,and the experimental group was treated with long-snake moxibustion combined with modified Duhuo Jisheng Decoction based on the control group for four consecutive weeks. Observe the clinical efficacy,the Japanese Orthopedic Association (JOA) score,and traditional Chinese medicine syndrome score of two groups of patients. Detect the serum levels of prostaglandin E2 (PGE2),transforming growth factor-β 1 (TGF-β1),interleukin-1β (IL-1β),matrix metalloproteinase-2 (MMP-2),and hypoxia-inducible factor-1α (HIF-1α) in two groups of patients. Results Compared with the control group (79.41％),the clinical efficaly of experimental group (94.12％) was increased (P<0.05). Compared with before treatment,TCM syndrome score of 2 groups was decreased,JOA score was increased,serum PGE2,TGF-β1,MMP-2,HIF-1α,and IL-1β were decreased after treatment (P<0.05). After treatment,compared with control group,TCM syndrome score of experimental group was decreased,JOA score was increased,serum PGE2,TGF-β1,MMP-2,HIF-1α,and IL-1β were decreased (P<0.05). Conclusion Long-snake moxibustion combined with modified Duhuo Jisheng Decoction can significantly reduce the inflammatory response of patients with liver-kidney deficiency pattern of lumbar disc herniation,inhibit the secretion of pain mediators,improve lumbar function,and thus improve clinical efficacy.