OBJECTIVETo observe the clinical therapeutic effect of acupuncture combined with western medicine for treatment of essential tremor.

METHODSSixty cases of essential tremor were randomly divided into two groups, 30 cases in each group. The combined acupuncture and medication group was treated with acupuncture at Baihui (GV 20), Sishencong (EX-HN 1), Taixi (KI 3), etc. and oral administration of Propranolol; the medication group was treated with oral administration of Propranolol only. The comprehensive effects and the scores of tremor were observed after 30 days of treatment in the two groups.

RESULTSThe total effective rate of 90.0% (27/30) in the combined acupuncture and medication group was obviously higher than that of 56.7% (17/30) in the medication group (P < 0.01), the tremor score of the combined acupuncture and medication group was obviously better than that of the medication group (P < 0.05).

CONCLUSIONAcupuncture combined with oral administration of Propranolol has better therapeutic effect on essential tremor than that of oral administration of Propranolol only.

Acupuncture Points ; Acupuncture Therapy ; Aged ; Combined Modality Therapy ; Essential Tremor ; drug therapy ; therapy ; Female ; Humans ; Male ; Middle Aged ; Propranolol ; therapeutic use ; Treatment Outcome

The neuroimaging results of drug-resistant epilepsy patients play an important role in the surgery decision and prognosis. The aim of this study was to evaluate the impact of these results on the efficacy of epilepay surgery, and then to explore surgical benefit for epilepsy patients with negative magnetic resonance (MR) images. Twenty-four subgroups describing the outcomes of 1475 epilepsy patients with positive-neuroimaging results and 696 patients with negative-neuroimaging results were involved in the meta-analysis. Overall, the odds of postoperational seizure-free rate were 2.03 times higher in magnetic resonance imaging-positive (MRI-positive) patients than in MRI-negative patients [odds ratio (OR)=2.03, 95% CI (1.67, 2.47), P<0.00001]. For patients with temporal lobe epilepsy (TLE), the odds were 1.76 times higher in those with MRI-positive results than in those with MRI-negative results [OR=1.76, 95% CI (1.34, 2.32), P<0.0001]. For patients with extra-temporal lobe epilepsy (extra-TLE), the odds were 2.88 times higher in MRI-positive patients than in MRI-negative patients [OR=2.88, 95% CI (1.53, 5.43), P=0.001]. It was concluded that the seizure-free rate of MRI-positive patients after surgery was higher than that of MRI-negative patients. For patients with negative results, an appropriate surgery should be concerned for TLE.
China ; epidemiology ; Epilepsy ; diagnosis ; epidemiology ; surgery ; Humans ; Magnetic Resonance Imaging ; statistics & numerical data ; Neurosurgical Procedures ; statistics & numerical data ; Prevalence ; Prognosis ; Reproducibility of Results ; Sensitivity and Specificity ; Surgery, Computer-Assisted ; statistics & numerical data ; Treatment Outcome

BACKGROUNDRecently, new anti-epileptic drugs (AEDs) have been more frequently selected to treat epilepsy. In the present study, we evaluated the dynamic changes of efficacy and safety of three newer AEDs for treating partial epilepsy in China.

METHODSPatients were collected sequentially and were divided into three groups which accepted oxcarbazepine (OXC), lamotrigine (LTG) or topiramate (TPM) therapy. Each group included monotherapy and add-on therapy subgroups. We followed all patients for one year and recorded the indexes of efficacy and safety in detail.

RESULTSA total of 909 patients finished the follow-up observation. No significant difference was found in proportion of patients with > or = 50% reduction, > or = 75% reduction and 100% seizure reduction in the LTG and OXC groups between the first and the second six months. In the TPM group there was a statistical difference between the first and the second six months in proportion of patients with > or = 50% reduction (P = 0.002), > or = 75% reduction (P < 0.0001) and 100% seizure reduction (P = 0.009) in the monotherapy subgroup, and about > or = 75% reduction and 100% seizure reduction in the add-on therapy subgroup (P < 0.0001). The efficacy between the add-on and monotherapy subgroups showed a statistical difference. The safety of the three newer AEDs was good.

CONCLUSIONSThe three newer AEDs all showed good efficacy and tolerability for partial epilepsy. And the efficacy can be maintained for at least one year.

Anticonvulsants ; therapeutic use ; Carbamazepine ; analogs & derivatives ; therapeutic use ; China ; Epilepsies, Partial ; drug therapy ; Follow-Up Studies ; Fructose ; analogs & derivatives ; therapeutic use ; Humans ; Treatment Outcome ; Triazines ; therapeutic use

Objective:To investigate the current situation of suicidal self-injurious behavior in teenagers and analyze its influencing factors. Methods:From January to November 2020， a stratified sampling method was used to investigate 707 teenagers in Guangdong. The “questionnaire of health-related behaviors of Chinese teenagers” compiled by the Chinese Center for Disease Control and Prevention was used anonymously to investigate the current situation of suicidal self-injurious behavior of the teenagers. The chi-square test was used for univariate analysis， and logistic regression was used for multivariate analysis. Results:The incidence rate of suicidal self-injurious behavior was 14.57% （103/707）. It was 13.31% （45/338） in males， 15.72% （58/369） in females， 13.83% （48/347） in junior high school students and 15.28% （55/360） in senior high school students. There was no statistical significance in the incidence of suicidal self-injurious behavior of teenagers between different genders， different learning stages， smoking or not， asexual behavior or not， gambling or not， and fighting or not （all P>0.05）. The incidence of suicidal self-injurious behaviors in teenagers from single parent family， drunkenness， runaway， loneliness， under great study pressure， lovelorn， and mobile phone addiction was significantly higher （χ²=13.809， 10.852， 14.279， 11.451， 12.893， 22.905， 19.473， respectively. All P<0.001）. Logistic regression analysis showed that the following were main risk factors affecting the incidence of suicidal self-injurious behavior in teenagers： single parent family （OR=3.826， 95%CI： 1.402-7.501）， drunkenness （OR=3.903， 95%CI： 1.512-7.368）， runaway （OR=3.447， 95%CI： 1.669-7.715）， loneliness （OR=3.613， 95%CI： 1.504-7.697）， great study pressure （OR=3.712， 95%CI： 1.387-7.604）， lovelorn（OR=4.125， 95%CI： 1.516-8.117） and mobile phone addiction（OR=4.027， 95%CI： 1.499-7.984 （all P<0.001）. Conclusion:The incidence of suicidal self-injurious behavior in teenagers is not low in Guangdong， and targeted measures should be developed to screen and intervene based on the influencing factors.