2.COX-2 induced angiogenesis and peritoneal adhesion
International Journal of Surgery 2008;35(8):524-528
Postoperative peritoneal adhesion represents a major complication of surgery. Recently, the angiogenesis which cyclooxygenase-2 enzyme induced was found to play an important role in the adhesion synthesis. This review summarized the relationship between COX-2 induced angiogenesis and peritoneal ad- hesion.
3.EFFECT OF TAURINE ON MODULATING CALCIUM OF CARDIAC MUSCLES IN RATS
Yi KANG ; Ping LI ; Guoxiang WANG
Chinese Pharmacological Bulletin 1986;0(04):-
The effect of Taurine ( Tau)on 45Ca influx of isolated left ventricular muscles in rats has been investigated. The 45Ca influx of the preparations untreated with Tau, are affected by the concentrations of calcium in KH solution. when the concentration of calcium is 0.62; 1.25; and 1.87mmol/L respectively, the 45Ca influx is 1.02? 0.25; 1.37?0.14 and 1.45?0.14 ?mol/g wet tissue, respectively. After adding Tau, the situations above were changed significantly. It was shown that is 1.11 ? 0.11, 1.45?0.12, and 1.48 ? 0.09 ?mol/g wet tissue in low Ca2?; 1.19?0.07, 1.14 ? 0.23, and 0.97?0.24 ?mol/g wet tissue in normal Ca2?; and 1.12?0.05,0.58?0.18 and 0.53?0.10 ?mol/g wet tissue in high Ca2? treated with Tau 10, 20, and 40 mmol/L, respectively. The results show that the varied ,Ca2? concentrations in KH solution can affect 45Ca influx of cardiac muscles, but Taurine has a bisphasic modulation o,f calcium influx in the same tissue. The effects of modulating calcium may play an important role for anti-arrhythmic mechanism of Taurine.
4.DSM-IV and ICD-10: A Comparison of Clinical Features of Attention Deficit-Hyperactivity Disorder and Hyperkinetic Disorder
Chuanyuan KANG ; Yufeng WANG ; Li YANG
Chinese Mental Health Journal 1989;0(03):-
Objective: To examine the differences on clinical features between DSM-Ⅳ ADHD and ICD-10 HKD patients. Methods:516 children referred to psychiatric clinic because of overactivity, inattention, and impulsivity symptoms were divided into two groups: Children meeting both criteria ( HKD-ADHD group, n=199), and children meeting only DSM-Ⅳ ADHD criteria (ADHD group, n=317). Diagnoses were confirmed by structured interview with parents using Clinical Diagnostic Interview Scale. Results: Whereas the combined type is predominant in HKD-ADHD group (75.4%), predominately inattentive type take account of the majority in ADHD group (67.2%). Compared to ADHD group, HKD-ADHD group includes the patients with younger referral age(9.6?2.2 vs 10.7?2.6) and earlier onset of age(4.6?1.9 vs 5.9?2.5), more opposite defiant disorder comorbidity (41.2% vs 26.2%), more disturbed behaviors, and higher sensory integrative dysfunction prevalence (72.6% vs 56.9% ). However, among the patients not older than 9-year-old there is higher prevalence of learning disability in ADHD group (26.7% vs 14.8%).Conclusion: ICD-10 criteria identified a severe group of patients than those identified by DSM-Ⅳ.However, the patients satisfied only DSM-Ⅳcriteria has exhibited more academic difficulty and behavioral disturbance compared with normal children, so we recommend DSM-Ⅳ as clinical diagnostic tool so that earlier interventions could be possible.
5.Epinephrine inhibited AQP1 expression in cultured bovine trabecular meshwork cells
Li ZHAO ; Fengying KANG ; Ningli WANG
Basic & Clinical Medicine 2006;0(05):-
Objective To explore the mechanism of epinephrine in down-regulating intraocular pressure.Methods The third passage bovine trabecular meshwork cells were divided into control group and epinephrine treated groups in random fashion.Different dosages of epinephrine(10-4、10-5 and 10-6mol/L) were added in cultures and incubated for 14 days.AQP1 expressions was stained by immunocytochemistry method,and the cell area was measured by computer image analytical system.Results The expressions of AQP1 and cell areas in epinephrine treated groups was significantly lower than control group(P
6.Analysis of the reason for misdiagnosis of sarcoidosis.
Chunlei WANG ; Jian KANG ; Zhenhua LI
Chinese Journal of Practical Internal Medicine 2001;0(05):-
Objective To explore the common reason for misdiagnosis of sarcoidosis to increase the diagnosis rate of sarcoidosis and reduce misdiagnosis rate.Methods Analyze clinical manifestation and misdiagnosis reason retrospectively of 98 patients confirmed sarcoidosis according to pathological proof,in which 39 patients are misdiagnosed.Results The major reasons for misdiagnosis were delitescent sarcoidosis progress,clinical manifestation lacking specificity and lack of research.The most common diseases misdiagnosed were pulmonary tuberculosis,lung cancer and lymphoma.Conclusion The major methods to reduce misdiagnosis are to know well about clinical characteristics,imageology manifestation and laboratory exam about sarcoidosis.
7.Effect of dicetaxin combined with psychological intervention on early cognitive function in the patients with hip arthroplasty
Chunsheng LI ; Xiangwu KANG ; Fuqiang WANG
Chinese Journal of Biochemical Pharmaceutics 2017;37(7):294-295,298
Objective To study the effect of eicetaxin combined with psychological intervention on early cognitive function in the patients with hip arthroplasty.Methods From January 2015 to December 2016 in our hospital, 80 cases with hip arthroplasty were selected as the research object, which were divided into two groups (the control group and the observation group) according to intervention methods, 40 cases in each groups.The control group were given dicetaxin, the observation group were received dicetaxin combined with psychological intervention.The clinical data in the two groups were compared.Results After intervention, the cognitive function in the observation group was better than that in the control group;the clinical intervention effect in the observation group (95.0%) was better than that in the control group (72.5%);The incidence of adverse reactions (7.5%) in the observation group is lower than that in the control group (40.0%).The difference of the above data in the two groups was statistically significant(P< 0.05).Conclusion The clinical effect is significant that dezocine combined with psychological intervention were used on patients with hip arthroplasty, which can improve the early cognitive function in the patients, is worthy of clinical application.
8.Therapeutic effect of granulocyte colony stimulating factor on CCl4 induced chronic liver injury in mice
Junping WANG ; Dianxing SUN ; Bingshun LI ; Fubiao KANG ; Minran LI ; Zhengrong GUO ; Jiwen KANG ; Weiyong LI
Chinese Journal of Digestion 2008;28(4):242-245
Objective To observe the therapeutic effects of recombinant human granulocyte colony stimulating factor(rhG-CSF)on CCl4 induced chronic liver injury.Methods Male BALB/C mice were randomly allocated into treatment and control groups.The mice model were established by injection with daily for 7 days,while the control mice were received the same volumes of saline.The mice were sacrificed to get weight,liver mass and spleen mass.The count of CD34+ cells and Thy-1+ cells were analyzed by flow cytometry and immunohistochemical staining,respectively.Results The ratio of liver/spleen was 15.94±1.20 and 10.52±0.66 on day 8 and 15 in treatment group,respectively,while those were 7.14±1.68 and 8.31±1.71 in control group,respectively(all P value<0.05).But there was no significant difference in body weight and liver mass between two groups(P>0.05)The concentration of album in treatment group was raised rapidly on day 15.The concentrations of alanine aminotransferase (ALT),aspartate aminotransferase(AST),hyaluronic acid(HA)and laminin(LN)on day 30 were significantly lower in treatment group compared to control group(P<0.05).There was significant difference in score of liver fibrosis on day 30 between two groups(treatment group:5.49±2.16,control:8.74±1.86,P<0.05).The number of CD34+ cell and Thy-1+ in treatment group(on day 8:9.54±2.24 and 5.10±1.25 and on day 15:8.18±1.93 and 7.53±1.39,respectively)were higher than those in control group(on day 8:5.40±0.99 and 3.25±0.75;on 15 days:4.46±0.77 and 3.35±0.86,all P value<0.05).Conclusion The rhG-CSF may improve the reparation of chronic liver injury,and may provide a novel method in treatment of liver fibrosis.
9.Monte Carlo dose calculation based on the virtual source model with linear accelerator and its preliminary application in independent dose calculation for IMRT plans
Bin TANG ; Shengwei KANG ; Xianliang WANG ; Jie LI ; Pei WANG
Chinese Journal of Radiation Oncology 2016;25(4):372-375
Objective To investigate the feasibility of the virtual source model in Monte Carlo dose calculation for clinical radiotherapy.Methods The Monte Carlo simulation was used to obtain the phase space files which recorded the physical properties of the particles emitted by a medical linear accelerator, and the information on the type, energy spectrum, and distribution of particles were extracted from these files and analyzed to establish the semi-empirical model of virtual two-photon source.The GMC dose calculation engine was used to obtain the 3 cm×3 cm, 5 cm×5 cm, 10 cm×10 cm, 20 cm×20 cm, and 30 cm×30 cm fields of radiotherapy and the results of Monte Carlo simulation of dose distribution in three-dimensional water phantom in 2 intensity-modulated radiotherapy ( IMRT) plans.These results were compared with the results of water phantom measurement or the results of Elekta Monaco planning system to verify the accuracy of Monte Carlo dose calculation based on a virtual source.Results As for the percentage depth-dose distribution curves of the central axis of the water phantom and the off-axis dose curves at different depths in the five fields for radiotherapy, the difference between the results of Monte Carlo simulation and the results of measurement was within 1%.As for the two IMRT plans, the three-dimensional passing rates of Monaco calculation results and Monte Carlo simulation results were 98.9%and 99.4%, respectively, for 3%/3 mm, and 95.1%and 95.4%, respectively, for 2%/2 mm.Conclusions Monte Carlo simulation based on the virtual source model can obtain accurate results of radiotherapy dose calculation.
10.Impacts of applicators on 192 Ir brachytherapy dosimetry
Xianliang WANG ; Shengwei KANG ; Jie LI ; Pei WANG ; Yan TAN
Chinese Journal of Radiation Oncology 2015;(5):585-587
Objective To study the impacts of different applicators on dose distribution in 192 Ir brachytherapy. Methods The inner tubes of two cylinder applicators from Nucletron,#101?001 and#084?350, were made of plastic and stainless steel, respectively. The cylinder parts of them were made of plastic, and had four different radiuses:1?00 cm, 1?25 cm, 1?50 cm, and 1?75 cm. EGSnrc program was used to simulate dose distribution when applicators were present in a phantom, and the results calculated by the treatment planning system were compared with the results of EGSnrc. The impacts of applicators on dose distribution were analyzed with different materials, thickness, and numbers of resident source. Results There was no significant relationship between dose deviation and the radius for the two applicators. When an applicator was present, the actual dose delivered to a patient was smaller than the planned dose. The dose deviation of the applicator#101?001 was no more than 1%, while the dose deviation of the applicator#084?350 was close to 3%. The dose deviation remained the same when the number of resident source changed. Conclusions The plastic applicator, if possible, is the best choice for brachytherapy right now. In a long term, in order to promote the accuracy of brachytherapy, current dosimetry algorithm should be improved, and the impacts of the applicator made of metal, such as stainless steel, on dose distribution should be taken into account.