1.The Effect of Antenatal Corticosteroid on Perinatal Outcomes of Preterm Births.
In Sik LEE ; Shin Myung SHIN ; Ji Ahn KANG ; Hye Sung WON ; Pyl Ryang LEE ; Ahm KIM ; Joo Hyun NAM
Korean Journal of Obstetrics and Gynecology 2000;43(5):863-870
OBJECTIVES: To determine the effectiveness and clinical utility of antenatal corticosteroids in the reduction of neonatal morbidity and mortality on preterm birth Material and method: Neonatal outcomes of 312 preterm babies were evaluated retrospectively. One hundred and two preterm babies(study group) were given dexamethasone more than 1 dose antenatally and 210 preterm babies(control group) were not given dexamethasone antenatally. Antenatal steroids were administered in the form of four 5mg intramuscular doses of dexamethasone 12 hours apart. Maternal and neonatal outcomes of study group were compared with those of control group. Student t- test, x2 test, Fisher's exact test, and logistic regression analysis were used where appropriate. p-value< 0.05 was considered significant. RESULTS: Antentenatal corticosteroid significantly decreased the incidence of RDS(OR:0.47, 95% CI:0.25-0.86), IVH/PVL(OR : 0.32, 95% CI : 0.12-0.86), necrotizing enterocolitis(OR : 0.49, 95% CI : 0.25-0.98), and neonatal death(OR: 0.30, 95% CI: 0.10 - 0.89) in preterm delivery. In the presence of PROM, antenatal corticosteoid seemed to have no protective effect on the neonatal complications such as RDS, IVH/PVL, NEC, PDA, and neonatal death. CONCLUSIONS: Antenatal administration of corticosteroids was effective to decrease the incidence of neonatal morbidity and neonatal mortality in the preterm neonates with no apparent maternal complications.
Adrenal Cortex Hormones
;
Dexamethasone
;
Humans
;
Incidence
;
Infant
;
Infant Mortality
;
Infant, Newborn
;
Logistic Models
;
Mortality
;
Premature Birth*
;
Retrospective Studies
;
Steroids
2.Uterine artery doppler velocimetry in growth-retarded pregnancies.
Bo Hyun YOON ; Yeong Je KANG ; Pyl Ryang LEE ; Hyun Jin SONG ; Hee Chul SYN ; Syng Wook KIM
Korean Journal of Perinatology 1991;2(2):102-110
No abstract available.
Pregnancy*
;
Rheology*
;
Uterine Artery*
3.Perinatal outcome in pregnancies associated with absent or reverse end-diastolic flow velocity on umbilical artery doppler velocimetry.
Yeong Je KANG ; Bo Hyun YOON ; Soon Ki HONG ; Pyl Ryang LEE ; Hee Chul SYN ; Syng Wook KIM
Korean Journal of Perinatology 1991;2(2):18-27
No abstract available.
Pregnancy*
;
Rheology*
;
Umbilical Arteries*
4.Interleukin-17 in Various Ocular Surface Inflammatory Diseases.
Min Ho KANG ; Mee Kum KIM ; Hyun Joo LEE ; Hyeon Il LEE ; Won Ryang WEE ; Jin Hak LEE
Journal of Korean Medical Science 2011;26(7):938-944
Recently, the association of Th-17 cells or IL-17 with ocular inflammatory diseases such as uveitis, scleritis and dry eye syndrome was discovered. We assessed whether interleukin (IL)-17 was present in the tears of various ocular surface inflammatory diseases and the tear IL-17 concentrations were clinically correlated with various ocular surface inflammatory diseases. We measured concentrations of IL-17 in tears of normal subjects (n = 28) and patients (n = 141) with meibomian gland dysfunction (MGD), dry eye syndrome (DES), Sjogren syndrome (SS), Stevens-Johnson syndrome (SJS), graft-versus-host disease (GVHD), filamentary keratitis, and autoimmune keratitis associated with rheumatoid arthritis or systemic lupus erythematosus. Clinical epitheliopathy scores were based on the surface area of corneal and conjunctival fluorescein staining. The mean concentrations of IL-17 in tears of patients with filamentary keratitis, GVHD, autoimmune keratitis, SS, DES, MGD, SJS were significantly higher in order than that in normal subjects. Tear IL-17 concentration was significantly correlated with clinical epitheilopathy scores in the patients with systemic inflammatory disease, while tear IL-17 was not correlated with clinical severity of the cornea and conjunctiva in the dry eye patients without any systemic inflammatory disease. Tear IL-17 is likely to correlate clinically with corneal disease severity only in the patients with systemic inflammatory disease.
Adult
;
Aged
;
Dry Eye Syndromes/*metabolism
;
Eye Diseases/diagnosis/*metabolism
;
Eyelid Diseases/metabolism
;
Female
;
Graft vs Host Disease/metabolism
;
Humans
;
Interleukin-17/*analysis
;
Keratitis/metabolism
;
Male
;
Meibomian Glands/physiopathology
;
Middle Aged
;
Severity of Illness Index
;
Sjogren's Syndrome/metabolism
;
Stevens-Johnson Syndrome/metabolism
;
Tears/metabolism
5.A Case of Idiopathic Light Chain Deposition Disease.
Kang Wook LEE ; Han Kyu LEE ; Young Mo LEE ; Ki Ryang NA ; Kwang Sun SUH ; Young Tai SHIN
Korean Journal of Nephrology 2005;24(1):146-151
Light chain deposition disease (LCDD) is a systemic disorder characterized by the deposition of monoclonal immunoglobulin light chains (LCs) in various organs. As LCs are overproduced by an abnormal clone of B cells, LCDD is usually described in the course of plasma cell dyscrasias or other lymphoproliferative disorders. However, it can occur in the absence of any detectable hematological disorder even during prolonged follow-up. We experienced a case of 62-year-woman who presented generalized edema, massive proteinuria and renal insufficiency. The histologic findings showed nodular glomerular mesangial expansion and prominent ribbon like immunohistochemical staining for kappa-light chain in the glomerular capillary wall. There was no evidence of multiple myeloma in bone marrow biopsy specimen. Because she refused the intensive chemothrapy, low dose of prednisolone and cyclophosphamide were prescribed for 6 months. Her renal function was maintained relatively well without renal replacement therapy for 7 months. We report a case of idiopathic LCDD not associated with multiple myeloma or other plasma cell dysclasia.
B-Lymphocytes
;
Biopsy
;
Bone Marrow
;
Capillaries
;
Clone Cells
;
Cyclophosphamide
;
Edema
;
Follow-Up Studies
;
Immunoglobulin Light Chains
;
Lymphoproliferative Disorders
;
Multiple Myeloma
;
Nephrotic Syndrome
;
Paraproteinemias
;
Plasma Cells
;
Prednisolone
;
Proteinuria
;
Renal Insufficiency
;
Renal Replacement Therapy
6.Common Arterial Trunk: Report of Five Atopsied Cases.
Gil Hyun KANG ; Yong Hee LEE ; Chong Woo YOO ; Choong Sik LEE ; Hong Ryang KIL ; Sang Ho CHO ; Jeong Wook SEO
Korean Journal of Pathology 1996;30(11):1027-1033
The common arterial trunk is a congenital cardiovascular malformation in which one arterial trunk gives origin to the aortic arch, pulmonary and coronary arteries. Other cardiovascular malformations are often associated, such as ventricular septal defect, aortic arch interruption, patent arterial duct and so on. During the early period of life, the persistence of the increased pulmonary arteriolar resistance results in cyanosis. As the pulmonary vascular resistance decreases, the cyanosis disappears but signs of congestive heart failure become the main problems. We report five cases of common arterial trunk that was confirmed by autopsy at Chungnam National University Hospital, Seoul National University Hospital, and Yonsei University Severance Hospital between 1983 and 1995. The ages of these patients at autopsy were 8-28 days and four of them were male. Pulmonary arteries arose as a pulmonary trunk in two cases but three cases showed two arteries arising separately from the posterior wall of the common trunk. The type of ventricular septal defect was juxtatruncal in every case. All five cases had three leaflet truncal valves but three cases showed dysplasia of the leaflets. Interruption of aortic arch was associated in two cases. The cause of death was renal failure in two cases, cardiac failure after corrective surgery in two cases, and pulmonary edema and failure in one case.
7.Effect of Anti-inflammatory Drug on the Cyclooxygenase-2 Protein Expression in Lipopolysaccharide-Stimulated Amnion Cells in Culture.
Pil Ryang LEE ; Bok Kyung JUNG ; So Ra KIM ; Ji Ahn KANG ; Myung Shin SHIN ; Hye Sung WON ; In Sik LEE ; Ahn KIM
Korean Journal of Perinatology 2000;11(4):490-497
No abstract available.
Amnion*
;
Cyclooxygenase 2*
8.Hyperammonemia in a Patient with Late-Onset Ornithine Carbamoyltransferase Deficiency.
Dae Eun CHOI ; Kang Wook LEE ; Young Tai SHIN ; Ki Ryang NA
Journal of Korean Medical Science 2012;27(5):556-559
Ornithine carbamoyltransferase (OTC) deficiency is a urea cycle disorder that causes the accumulation of ammonia, which can lead to encephalopathy. Adults presenting with hyperammonemia who are subsequently diagnosed with urea cycle disorders are rare. Herein, we report a case of a late-onset OTC deficient patient who was successfully treated with arginine, benzoate and hemodialysis. A 59-yr-old man was admitted to our hospital with progressive lethargy and confusion. Although hyperammonemia was suspected as the cause of the patient's mental changes, there was no evidence of chronic liver disease. A plasma amino acid and urine organic acid analysis revealed OTC deficiency. Despite the administration of a lactulose enema, the patient's serum ammonia level increased and he remained confused, leading us to initiate acute hemodialysis. After treatment with arginine, sodium benzoate and hemodialysis, the patient's serum ammonia level stabilized and his mental status returned to normal.
Age of Onset
;
Ammonia/blood
;
Arginine/therapeutic use
;
Citrulline/blood
;
Humans
;
Hyperammonemia/*etiology
;
Male
;
Middle Aged
;
Ornithine/blood
;
Ornithine Carbamoyltransferase Deficiency Disease/complications/*diagnosis/drug therapy
;
Pedigree
;
Renal Dialysis
;
Sodium Benzoate/therapeutic use
9.A Case of Scrub Typhus Complicated with Acute Renal Failure Meningoencephalitis and Hepatitis.
Jong Sub KIM ; Bon Jeong KU ; Ki Ryang NA ; Seoun Mee OH ; Ki Tai BIN ; Seong Suk KIM ; Kang Wook LEE ; Young Tai SHIN
Korean Journal of Medicine 1997;53(3):436-439
Scrub typhus is a zoonosis transmitted by a chigger of trombiculid mite and manifested with fever, skin rash, myalgia, and hepatitis etc. The renal involvement of the disease is prese-ted with transient microscopic hematuria and/or proteinuria. However acute renal failure or meningoencephalitis is very rare. We report a case of scrub typhus manifested with acute renal failure, meningoencephalitis, and hepatitis. The patient was treated with doxycycline and continuous arteriovenous hemofiltration (CAVH) and recovered successfully.
Acute Kidney Injury*
;
Doxycycline
;
Exanthema
;
Fever
;
Hematuria
;
Hemofiltration
;
Hepatitis*
;
Humans
;
Meningoencephalitis*
;
Myalgia
;
Proteinuria
;
Scrub Typhus*
;
Trombiculidae
10.Effects of Etomidate, Thiopental Sodium and Propofol on Intraocular Pressure Associated with Tracheal Intubation.
Kyu Sik KANG ; Kyung Ho BANG ; Ki Ryang AHN ; Jin Hyung KWON ; Jung Suk LEE
Korean Journal of Anesthesiology 2005;48(6):582-586
BACKGROUND: During ophthalmologic surgery, various intravenous anesthetic induction agents are used to prevent an intraocular pressure (IOP) increase. This study was designed to compare the effects of etomidate on IOP with those of thiopental sodium and propofol in patients receiving vecronium bromide, and in whom tracheal intubation was performed. METHODS: Forty-five patients undergoing elective surgery were ramdomized to receive etomidate 0.3 mg/kg (E group, n = 15), thiopental sodium 5 mg/kg (T group, n = 15) or propofol 2.5 mg/kg (P group, n = 15). IOP, systolic arterial pressure (SAP) and heart rate (HR) were measured before induction (B), after the adminstration of the induction agents (I1), before intubation (I2) and at 1, 2 and 3 mins after intubation (T1, T2 and T3). RESULTS: The IOP after I1 and I2 in the E , T and P groups were significantly lower than in group B (P < 0.05). The IOP at T1, T2 and T3 in the E, T and P groups were not found to be significantly different from group B. The IOP, SAP and HR at T1, T2, and T3 in the E, T and P groups were significantly higher than at I1 and I2 (P < 0.05). No significant differences were observed between the groups in term of IOP. The SAP and HR at T1, T2 and T3 in the P group were significantly lower than in the other two groups (P < 0.05). CONCLUSIONS: We concluded that etomidate, thiopental sodium and propofol may be useful induction agents for general anesthesia in ophthalmologic surgery but that they do not prevent IOP elevation during endotracheal intubation.
Anesthesia, General
;
Arterial Pressure
;
Etomidate*
;
Heart Rate
;
Humans
;
Intraocular Pressure*
;
Intubation*
;
Intubation, Intratracheal
;
Propofol*
;
Thiopental*