Recently many studies have focused on the roles that tumor microenvironment plays in the occurrence and development of tumors,and the therapeutic effects of adjuvant chemotherapy and neoadjuvant chemotherapy.Recent researches show that tumor microenvironment has an obvious impact on the therapeutic effects of neoadjuvant chemotherapy,which mainly includes cancer-associated fibroblasts (CAF),stromal cell derived factor-1 (SDF-1) and collagens.

Carcinoma, Hepatocellular ; diagnosis ; diagnostic imaging ; pathology ; Humans ; Liver Neoplasms ; diagnosis ; diagnostic imaging ; pathology ; Magnetic Resonance Imaging ; Tomography, X-Ray Computed ; Ultrasonography

The association between psychogenic illness and human endogenous viruses (HEVs), including human endogenous retrovirus and Borna disease virus, remains unclear. As the component of human genome, HEVs may become the joint of various pathogenic factors of schizophrenia (SZ), such as heredity, environment, and immunity. In this review, we strive to uncover the clinical and laboratory evidence for the roles and possible pathogenic mechanism of HEVs in the development of SZ.
Animals ; Environment ; Humans ; Schizophrenia ; etiology ; genetics ; immunology ; virology ; Viruses ; genetics

Objective To observe the effectiveness of treating essential thrombocytosis(ET) with Buyang Huanwu Decoction plus hydroxyurea. Methods 120 patients with ET were randomly divided into observation group(OG) and control group(CG). Patients from OG were treated with Buyang huanwu decoction plus hydroxyurea, while those from CG were given hydroxyurea. After 6 months, the treatment effectiveness indexes including symptoms in a sense of chinese medicine, cell counts and saffy were observed. Results Total effective rate of OG was higher than that of CG(P<0.05). TCM symptoms remission in OG group was better than that of CG(P<0.05). After treatment, blood platelet count and megakaryocyte count were decreased in two groups(P<0.05), and the difference between two groups was signiifcan(P<0.05). Conclusion The therapy combined Chinese and western medicine deals with ET is better than simple western medicine treatment.

Brain Diseases ; etiology ; therapy ; Heat Stroke ; complications ; therapy ; Humans ; Hyperbaric Oxygenation ; Male ; Middle Aged ; Occupational Diseases ; complications ; therapy

Animals ; Biogenic Monoamines ; metabolism ; Brain ; drug effects ; metabolism ; Female ; Lipid Peroxidation ; drug effects ; Male ; Mice ; Paraquat ; toxicity

Small RNA (miRNA) can regulate post-transcriptional level of mRNA. miRNA is closely related to the occurrence and development of a variety of human diseases such as gastric cancer, lung cancer, breast cancer, ovarian cancer, prostate cancer, pancreatic cancer, liver cancer, etc. Many kinds of miRNAs in human cancers are significantly abnomadly expressed. miRNA can be regarded as a marker for many human cancers diagnosis.

2 cm). All patients received combination chemotherapy of abdomen and vein with CAP regime and TP regime after sections.Results:Total five year survival rates were 11% in epithelial ovarian carcinoma in stage Ⅲ. The 1-.3-.5-year survival rates of the cases which had less than 4 cycles of chemotherapy were lower than those ≥6 cycles, and the recurrent rates were higher than those ≥6 cycles. The 1-.3-.5-year survival rates of TP regime were higher than those of CAP regime,and the recurrent rates were lower than those CAP regime.Conclusions:There are many relationships between prognosis and residual tumor, nucmber of chemotherapy cycles or regime after resection,which influence results of recurrent ovarian cancer after repeated tumorectomy.

Objective To evaluate the clinical features and early management of combined thoracoabdominal injury (CTI).Methods A retrospective study was carried out in 29 cases with CTI treated surgically.There were 21 cases with penetrating injuries and 8 cases with blunt injuries.All cases were associated with penumothorax and/or hernothorax at various degrees and 13 cases complicated with shock.In this study thoracotomy was performed in 17 cases,laparotomy in 6 cases,thoracotomy plus laparotomy in 5 cases and combined thoraco-laparotomy in 1 case.Results The injury severity score in this series was (40.16±15.23) scores.Four cases were died from hemorrhagic shock (2 cases),pericardial tampenade(1 case) and multiple organ failure(1 case).Conclusions CTI has high mortality rate,and the most frequent cause of death is hypovolemic shock.The operative approach is based on individual injury condition.Early diagnosis and timely surgical intervention are key to improving the cure rate and reducing mortality in severe CTI.

Objective To investigate the clinical manifestations and prognosis of infants less than three months with kawasaki disease (KD).Methods Clinical manifestations,diagnosis,treatment and follow-up of the infants less than 3 months diagnosed with KD and hospitalized from Jan 2009 to Jan 2012 in Capital Institute of Pediatrics were collected and reviewed.Results Fourteen infants less than 3 months were diagnosed as KD during recent 3 years.Among them 8 cases were diagnosed as typical KD,6 cases as incomplete KD.The infants with KD had clinical features as fever longer than 5 d (14/14),cervical lymphadenopathy (11/14),rash (11/14),extremity changes (9/14),mucositis (10/14),conjunctivitis (5/14).Infants with incomplete KD had fever longer than 5 d (6/6) and extremity changes (4/6),cervical lymphadenopathy (3/6),rash (3/6).But fewer infants (2/6) had extremity changes later than 2 weeks.It was difficult to diagnose atypical KD earlier.More than half (8/14) of all the infants with KD had complications,6/14 had damaged liver function.Nearly all the cases (12/14) received intravenous immunoglobulin 1 g/.(kg·d) within 10 d of presentation.The coronary artery lesion was found in 2 infants during hospitalization.2 cases were found to have CAL during the follow-up after discharge from the hospital.The coronary artery lesion of the 4 infants recovered during follow-up.Conclusion Infants less than 3 months have higher rate of incomplete KD.All infants with KD should be followed-up and monitored for the coronary artery lesion.