Objective:To understand the basic information such as age,job title,and education of rehabilita-tion therapists in the Grade Ⅲ public psychiatric hospitals in China,and provide fundamental data for the construc-tion of the mental health rehabilitation talent team.Methods:The staffing of rehabilitation therapists in 43 Grade Ⅲpublic psychiatric hospitals in eastern,central,and western regions of China were investigated.The age,education,job title,professional relevance and inter-regional differences of the rehabilitation therapists were statistically ana-lyzed.Results:There were 197 rehabilitation therapists in 43 hospitals surveyed.The age distribution was mainly in 20-30 and 30-40 years old with a bachelor's degree and junior,and more than half of the personnel had their first academy degree related to the rehabilitation profession.The differences in age,education,job title were statistically significant in the eastern,central and western regions.Conclusion:The overall quality of the rehabilitation therapists in China's Grade Ⅲ public psychiatric hospitals is relatively high,and the age structure is reasonable.However,the proportion of senior professional titles is relatively low.Therefore,it is necessary to focus on talent training and the establishment of promotion systems in the future,in order to improve the professional development space and level of the entire industry.

Objective:To predict the gastrointestinal side effects of chemotherapeutic drugs using healthy murine colon organoids.It aimed to identify safer alternative treatments for patients intolerant to certain chemotherapy regimens and demonstrate the potential clinical ap-plications of organoids in predicting gastrointestinal side effects.Methods:Healthy mouse colonic crypt cells were cultured in 3D.Paraffin sections of colon tissues and organoids were subsequently prepared,followed by haematoxylin and eosinand immunohistochemical staining(CDX2,Ki67,and CK19).The colonic organoids were treated with five chemotherapeutic drugs,and cell activity was assessed to determine their intestinal toxicity.The consistency of the incidence of gastrointestinal side effects observed in this study and in clinical practice were analyzed by comparing the results to the published literature.Results:The histological characteristics of the colon organoids were highly consistent with those of the original colon tissues.The tolerance of normal colon organoids to different chemotherapeutic drugs was vari-able.Capecitabine had the least cytotoxic effect on mouse colon organoids,whereas paclitaxel liposomes showed the strongest cytotoxic ef-fect when IC50 was the only consideration.Considering clinical drug concentrations,a significant difference was observed in the organoid in-hibition rates between albumin paclitaxel and liposomal paclitaxel.Statistical analysis of clinical trial data showed that the incidence of gradeⅢ/Ⅳ diarrhea caused by albumin paclitaxel,epirubicin,capecitabine,and cyclophosphamide was consistent with the corresponding or-ganoid inhibition rates.Conclusions:Combining clinical drug doses,we recommend prioritizing albumin paclitaxel and avoiding the use of liposomal paclitaxel to improve chemotherapy tolerance.This study demonstrates that normal colon organoids can effectively predict the occurrence of severe diarrhea associated with most chemotherapeutic drugs.