2.Assessment of Autonomic Function in Alzheimer's Disease and Mild Cognitive Impairment Using Heart Rate Variability.
Han SEO ; Hyun KIM ; Kang Joon LEE
Korean Journal of Psychosomatic Medicine 2013;21(1):55-61
OBJECTIVES: Alzheimer's disease(AD) and mild cognitive impairment(MCI) affect several nervous structures involved with the autonomic nervous system. Association between neuropsychiatric deficits and heart rate variability has been observed. But cardiac autonomic function in AD has been scarcely studied and the results reported are conflicting. We investigated autonomic function in normal control, MCI, AD using heart rate variabil-ity(HRV) technique. METHODS: Time and frequency-domain variability of 5-min R-R interval series was comparatively evaluated in 26 normal control subjects, 22 MCI subjects and 34 AD subjects. Analysis of variance(ANOVA) was used to compare the differences across groups. Correlations between MMSE-KC and HRV components were performed using Pearson's correlation coefficient. RESULTS: No significant difference was observed among the groups in time, frequency-domain analysis of HRV (p>0.05). HRV were not found to be significantly correlated with the degree of cognitive impairment. CONCLUSIONS: There were no differences in HRV with MCI, AD subjects when compared with normal controls. Further investigation is required to use HRV technique as noninvasive parameters of MCI and AD.
Alzheimer Disease
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Autonomic Nervous System
;
Heart
;
Heart Rate
;
Mild Cognitive Impairment
3.Cystic Lesions in Os Calcis
Ki Ser KANG ; Han Koo LEE ; Sung Ho HAN
The Journal of the Korean Orthopaedic Association 1976;11(3):571-575
The authors experienced six patients who were admitted in Department of Orthopedic Surgery at Seoul National University Hospital during the period of March 1966 to February 1976 with cystic lesions in calcaneus by radiographic findings. The following results were obtained. Among the six patients, four were osteomyelitis, one was eosinophilic granuloma and the other was fibromyxoid sarcoma. They were all similar in radiographic findings, but were different each other in pathologic findings. 2. Diagnosis is very difficult only with the patients history, hematologic and radiographic findings and the pathologic findings is the most important in the final confirmative diagnosis from benign cystic lesions to malignant one. 3. We describe about the kinds and points of the differential diagnosis. of the other discases from the reported six cases.
Calcaneus
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Diagnosis
;
Diagnosis, Differential
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Eosinophilic Granuloma
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Humans
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Orthopedics
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Osteomyelitis
;
Sarcoma
;
Seoul
4.28 Cases of Metastatic Tumors to the Kidney.
Shin Han LEE ; Kang Hyun LEE ; Kie Hwan KIM
Korean Journal of Urology 2000;41(1):29-34
No abstract available.
Kidney*
5.Leukocyte-Endothelial Cell Adhesion Induced by Ischemia and Reperfusion Observed with in vivo Videomicroscopy.
Young Bae LEE ; Han Sug KANG ; Shin Byung PARK
Journal of Korean Neurosurgical Society 2000;29(10):1289-1295
No abstract available.
Cell Adhesion*
;
Ischemia*
;
Microscopy, Video*
;
Reperfusion*
6.Clinical analysis of Krukenberg tumor: a review of 18 cases.
Yong Wook KIM ; Han Woo LEE ; Jae Seong KANG
Korean Journal of Obstetrics and Gynecology 1991;34(10):1451-1456
No abstract available.
Krukenberg Tumor*
7.The function of frontal lobe of schizophrenics on the neuropsychological test.
Hyeun Sook KANG ; Sung Hoon LEE ; Eun Sun HAN
Journal of Korean Neuropsychiatric Association 1992;31(2):267-274
No abstract available.
Frontal Lobe*
;
Neuropsychological Tests*
8.Evaluation of EL-ANA/6 Profiles for Specific Antinuclear Antibodies.
Han Sung KIM ; Hee Jung KANG ; Kyu Man LEE
Korean Journal of Clinical Pathology 1997;17(4):643-649
BACKGROUND: Identification of specific antinuclear antibodies is useful for the diagnosis, subclassification and determination of prognosis in autoimmune disorders. In many diseases, multiple autoantibodies are detected, and simultaneous detection of multiple autoantibodies has been shown to be useful. Recently, a commercial kit (EL-ANA/6 profiles, TheraTest Laboratories, USA) losing enzyme-linked immunosorbent assay (ELISA) method for detection of six specific autoantibodies is avallable. In this study, we attempted to compare the results of EL-ANA/6 profiles with those of routinely used methods and evaluated usefulness of EL-ANA/6 profiles. METHODS: EL-ANA/6 profiles were performed with 28 sera which were positive for fluorescent antinuclear antibody (FANA) Simultaneously we tested anti-dsDNA antibodies with immnofluorescent (If) method and anti-Sm, anti-RNP, anti-SSA and anti-SSB antibodies with double immunodiffusion (DID). To evaluate specificity, EL- ANA/6 profiles tests were performed on 10 sera from healthy blood donors. RESULTS: Ten sera of healthly blood donors were all negative for EL-ANA/6 pro biles. In the results of EL-ANA/6 profiles on sera positive for FANA, the concordance rate with IF method for the anti-dsDNA antibodies was 89.3% (25/28) and the con- cordance rates with DID for anti-Sm, anti-Sm/RNP, anti-SSA and anti-SSB antibodies were 85.7% (24/28), 82.1% (23/28), 92.9% (26/28) and 82.1% (23/28), respectively. In 16 discordant settings, thirteen (81.3%) were negative on DID and positive on EL-ANA/6 profiles. CONCLUSIONS: The results of the EL-ANA/6 profiles show good concordance rates with If and DID. EL-ANA/6 profiles showing quantitative profiles for multiple autoantibodies is useful for diagnosis and tool)ow-up of autoimmune disorders.
Antibodies
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Antibodies, Antinuclear*
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Autoantibodies
;
Bile
;
Blood Donors
;
Diagnosis
;
Enzyme-Linked Immunosorbent Assay
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Humans
;
Immunodiffusion
;
Prognosis
;
Sensitivity and Specificity
9.The Economic Impact of a Rural Hospital to local Economy.
Im Ok KANG ; Sun Hee LEE ; Han Joong KIM
Korean Journal of Preventive Medicine 1996;29(4):831-842
Demand for high quality medical care has recently been increasing in step with high level of income and education. Patients prefer the use of large general hospitals to small community hospitals. Large hospitals, usually located at urban area, expand their capacities to cope with the increasing demand, therefore, they easily secure revenue necessary for growth and development of hospitals. However, small community hospitals are facing with serious financial difficulties caused from the reduction of patients in one hand and the inflation of cost in another. If small rural hospitals were closed, the closure would have negative impacts on local economies in addition to the decrease in access to medical care. Community leaders should have an insight on the contribution of community hospitals to local economies. They could make a rational decision on the hospital closure only with the understanding of hospital's contribution to the community. This study is designed to develop an economic model to estimate the contribution of rural hospital to local economies, and also to apply this model with a specific hospital. The contribution of a hospital to local economies consists of two elements, direct effect and multiplier effects. The direct impacts include hospital's local purchasing power, employee's local purchasing power, and the consumption of patients coming from outside the community. The direct impact induces multiplication effect in the local economy. The seed money invested to other industries grows through economic activities in the economy. The seed money invested to other industries grows through economic activities in the region. This study estimated the direct effect with the data of expenditure of the case hospital. The total effect was calculated by multiplied the direct effect with a multiplier. The multiplier was drown from the ratio of marginal propensity of income and expenditure. Beside the estimation of the total impacts, the economic effect from the external resources was also analyzed by the use of the ratio of patients coming outside the region. The results are as follows. 1. The direct economic contribution of the hospital to the local economy is 1,104 million won. 2. The value of multiplier in the region is 2.976. 3. The total economic effect is 3,286 million won, and the multiplication effect is 2,182 million won. 4. The economic contribution from the external resources is 245 million won which is 7.5% of the total economic effect.
Education
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Growth and Development
;
Hand
;
Health Expenditures
;
Health Facility Closure
;
Hospitals, Community
;
Hospitals, General
;
Hospitals, Rural*
;
Humans
;
Inflation, Economic
;
Models, Economic
10.The Effects of the Flexible and Rigid External Fixation on the Fracture Healing: An Experimental Study in Rabbits
Han Koo LEE ; Moon Sang CHUNG ; Ki Sir KANG
The Journal of the Korean Orthopaedic Association 1984;19(3):517-523
In order to compare the effects of the flexible external fixations with the rigid one on fracture healing, rabbits tibiae were fractured surgically and each fracture were immobilized with external devices using graphites (the group I), plastics (the group II) and stainless steel (the group III). At six weeks after fracture, clinical and radiological union rates in group I, II and III were 91% 73% and 60% respectively. The rabbits tibiae were load in 4-point bending test to determine the mechanical properties of the fracture healing. The means and standard errors of maximum bend moment of the fractured tibiae were 11. 30±2.33kg.f. cm., 8.55±2.02kg.f. cm. and 9.79±2.09kg.f. cm. in group I, II and III respectively. These data may suggest that a certain amount of the flexibility (ex, graphite) or motion is better than the rigidity (ex, stainless steel) in fracture healing by the method of the external immobilization).
Fracture Healing
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Graphite
;
Methods
;
Plastics
;
Pliability
;
Rabbits
;
Stainless Steel
;
Tibia