1.A Congenital Lateral Cervical Cyst Accompanying Respiratory Distress in a Male Neonate.
Journal of the Korean Medical Association 2000;43(11):1125-1130
No abstract available.
Humans
;
Infant, Newborn*
;
Male*
2.The effect of vitamine E on intestinal tumorigenesis by 1,2-dimethylhydrazine.
Kang Hyuk LEE ; Dae Young KANG
Journal of the Korean Cancer Association 1991;23(1):29-38
No abstract available.
1,2-Dimethylhydrazine*
;
Carcinogenesis*
;
Vitamins*
3.Alteration of Serum Insulin-like Growth Factor(IGF)-I and IGF-Binding Protein-2 in Healthy Population with Aging.
Kang Cheol YOON ; Dae Yeol LEE
Journal of Korean Society of Pediatric Endocrinology 1998;3(1):7-12
PURPOSE:Insulin-like growth factors, IGF- I and IGF-II, are proteins that promote cellular growth and differentiation of the various organs including the kidney. These peptides circulate in serum bound to specific carrier proteins, called IGF binding proteins(IGFBPs). The IGFs are produced in most organs but liver is believed to be the principal source of circulating IGF-I. We studied the correlation of serum IGF-I and IGFBP-2 pattern with aging. METHODS:Sera were collected from 320 healthy population who were grouped according to age. IGF-I was seperated from IGFBPs by Sephadex G-50 acid chromatography. We measured serum IGF-I and IGFBP-2 by using radioimmuno-assay (RIA) and immunoradiometric assay (IRMA) respectively. RESULTS:Serum IGF-I levels were quite low in early childhood, rising slowly and reaching a peak during puberty and a significant decline(P<00.01) during adulthood. The age-dependent pattern of serum IGFBP-2 levels shows a pattern opposite to that of IGF-I which are high at birth, decline by late puberty and increase again with aging. CONCLUSION: Our results demonstrate the alteration of serum IGF-I and IGFBP- 2 pattern with aging. These data suggests that when these tests are performed in the clinic, their interpretation should be based upon age specific criteria.
Adolescent
;
Aging*
;
Carrier Proteins
;
Chromatography
;
Humans
;
Immunoradiometric Assay
;
Insulin-Like Growth Factor Binding Protein 2
;
Insulin-Like Growth Factor Binding Proteins
;
Insulin-Like Growth Factor I
;
Insulin-Like Growth Factor II
;
Intercellular Signaling Peptides and Proteins
;
Kidney
;
Liver
;
Parturition
;
Peptides
;
Puberty
5.Ca Effects on Synthesis and Secretion of Insulin-like Growth Factor(IGF-I) and IGF-Binding Proteins by the Perfased Rat Liver
Dae Yeol LEE ; Chang Won KANG ; Jung Soo KIM
Journal of Korean Society of Endocrinology 1996;11(2):189-198
Background: The insulin-like growth factors, IGF-I and
Animals
;
Calcimycin
;
Calcium
;
Egtazic Acid
;
Extracellular Fluid
;
Glucose
;
Hepatocytes
;
Insulin
;
Insulin-Like Growth Factor Binding Protein 3
;
Insulin-Like Growth Factor Binding Proteins
;
Insulin-Like Growth Factor I
;
Liver
;
Metabolism
;
Parathyroid Hormone
;
Perfusion
;
Rats
;
Somatomedins
6.Study on the therapeutic effects of interferon and gamma-globulin in experimental Pneumocystis carinii pneumonia.
Dae Whan SHIN ; Dae Young KANG ; Young Ha LEE ; Young Eun NA ; Keon Jung YUN
The Korean Journal of Parasitology 1992;30(3):219-226
This study was performed to observe the therapeutic effects of interferon-gamma(IFN-gamma) and gamma-globulin(gamma-globulin) in experimental Pneumocystis carinii pneumonia of immune suppressed mice. After 9 weeks, trimethoprim-sulfamethoxazole(TMP-SMZ; 10-50 mg/mouse/day), mouse IFN-gamma(5 x 10(4) units/mouse/day) and mouse gamma-globulin(20 mg/mouse/day) were administered to the mice for 3 weeks by the experimental group. The therapeutic efficacy was evaluated by body weights, histopathologic and electron microscopic findings of the lungs, and number of P. carinii cysts by Gomori's methenamine silver stain. Body weights of the mice were significantly increased in the group of combination therapy of TMP-SMZ with IFN-gamma or gamma-globulin, and in the group of TMP-SMZ treatment (p < 0.05), however, little effect was found in the group of gamma-globulin alone. Histopathologic findings of P. carinii pneumonia were much improved in the group of combination therapy of TMP-SMZ with IFN-gamma. Treatment with either TMP-SMZ or IFN-gamma significantly reduced the number of cysts in the P. carinii pneumonia, but gamma-globulin alone was ineffective. In electron microscopic findings of P. carinii pneumonia, the number of trophozoites and cysts were reduced by treatment with either TMP-SMZ or IFN-gamma, and most of the cysts were empty or containing one or two intracystic bodies. The present results suggested, that combination therapy of TMP-SMZ with IFN-gamma had synergistic effects in treatment of P. carinii pneumonia in experimental mice.
Drug-Synergism
;
Drug-Therapy,-Combination
;
English-Abstract
;
Gamma-Globulins-administration-and-dosage
;
Interferon-Type-II-administration-and-dosage
;
Mice-
;
Trimethoprim-Sulfamethoxazole-Combination-administration-and-dosage
;
*Gamma-Globulins-therapeutic-use
;
*Interferon-Type-II-therapeutic-use
;
*Pneumonia,-Pneumocystis-carinii-therapy
;
Gamma-Globulins
;
Trimethoprim-Sulfamethoxazole-Combination
;
Interferon-Type-II
7.Clinical Analysis on Organisms Isolated from Blood Culture.
Dong Min KANG ; Jong Seo LEE ; Hong Dae CHA ; Tae Chan KWON ; Chin Moo KANG
Journal of the Korean Pediatric Society 1988;31(1):40-47
No abstract available.
8.A case of Ovarian Metastasis from Carcinoma of the Gallbladder: a rare Krukenberg Tumor.
Seong Wook CHUNG ; Joo Myeong LEE ; Kei Hyun LEE ; Sang Dae KANG ; Suk Hee LEE
Korean Journal of Obstetrics and Gynecology 2000;43(4):755-758
A wide variety of cancers metastasize to the ovaries. In a majority of instances the primary site is the gastrointestinal tract, breast, or other gynecologic organs. The best known tumor of this type is signet-ring cell adenocarcinoma. The gallbladder and bile duct are rare sources of these metastases. The authors have had an experience of a case that was presented of Krukenberg tumor metastatic from the gallbladder and report the case with brief review of literature.
Adenocarcinoma
;
Bile Ducts
;
Breast
;
Female
;
Gallbladder*
;
Gastrointestinal Tract
;
Krukenberg Tumor*
;
Neoplasm Metastasis*
;
Ovary
9.Applicability of Genes of Cancer-associated Testis Antigens in Diagnosis of Cancer.
Jong Wook PARK ; Soo Jung YOON ; Mi Hyun LEE ; Kang Dae LEE ; Tae Hyun YU
Korean Journal of Immunology 1999;21(3):221-228
Genes of cancer-associated testis antigens (CTAs) are expressed in various cancer tissues. In order to use CTAs as cancer diagnosis marker, we developed molecular method for detection of CTAs transcripts in tissue. In order to know the applicability of DNA of cancer-associated testis antigens (CTAs) on cancer diagnosis, molecular diagnostic methods for detection of gene expression of melanoma antigen gene (MAGE), GAGE, and B melanoma antigen (BAGE) was studied. After comparing DNA sequences of CTAs, S1/AS1 and S2/AS2, GAGE-S/ GAGE-AS, and BAGE-S/BAGE-AS primers were designed for the detection of MAGEs, GAGEs and BAGEs, respectively. The gene expression of CTAs in cancer cell lines, head and neck cancer tissues, ovary cancer tissue, and peritoneal cells of gastric cancer patients were investigated by reverse transcription-polymerase chain reaction (RT-PCR) using these primers. The MAGEs, GAGEs and BAGE genes were expressed in 8/8 (100%), 5/8 (62.5%) and 1/8 (12.5%) of head and neck cancer tissues, respectively. The gene expression of MAGEs were also detected in 8/10 (80%) of ovary cancer tissues and in 9/10 (90%) of peritoneal cells of gastric cancer patients in RT-PCR test using S1/AS1 primers. The results of this study suggest that molecular diagnosis method using CTAs genes, especially RT-PCR using S1/AS1 primer combination, is useful for diagnosis of cancer and it will be used for the prediction of cancer progression or regression and metastasis in future.
Base Sequence
;
Cell Line
;
Diagnosis*
;
DNA
;
Gene Expression
;
Head and Neck Neoplasms
;
Humans
;
Melanoma
;
Neoplasm Metastasis
;
Ovarian Neoplasms
;
Pathology, Molecular
;
Stomach Neoplasms
;
Testis*
10.A comparison of ritodrine hydrochloride(Yutopar@) and nifedipine in the treatment of preterm labor.
Jeong Seung LEE ; Jang Heub KIM ; Do Kang KIM ; Dae Hoon KIM ; Hun Young LEE
Korean Journal of Obstetrics and Gynecology 1991;34(3):340-347
No abstract available.
Female
;
Nifedipine*
;
Obstetric Labor, Premature*
;
Pregnancy
;
Ritodrine*