Objective: To evaluate the antioxidant and anticancer potential of different fractions of bark of Costus pictus using various in vitro antioxidant assay systems. Methods: In this study, assay like DPPH radical, superoxide anion radical scavenging activity, nitric oxide scavenging activity, hydrogen peroxide scavenging activity, metal chelating activity and reducing power were used. The concentrations of total phenolic and flavonoids were also calculated for the extracts.Result:pictus. This study suggested that, among the three fractions, the chloroform fraction possesses high antioxidant activity which might be helpful in preventing or slowing the progress of various oxidative stress related disorders. Moreover, all fractions possess potent anticancer properties against colon cancer cells of HT29 and lung carcinoma cells of A549. Conclusions: It can be concluded that the extract of the bark of C. pictus has potential natural antioxidant and this can be used in food industries. There are few reports on the antioxidant capacity of bark of C. pictus and the mechanism of different fractions of bark of C. pictus as antioxidative agents is still not fully understood. Hence further research is underway to analyse and isolate the active compounds responsible for the antioxidant and anticancer activity of different fractions of the bark of C.pictus. The present study elucidated for the first time the antioxidant property of bark of C.

Squamous cell carcinoma (SCC) arising within the lining of an odontogenic keratocyst (OKC) is a rare occurrence. Although potentially locally destructive, OKC is a benign odontogenic process that typically presents with clinical and radiographic features characteristic of a benign intraosseous neoplasm. We present the clinical and radiographic features of a maxillary mass that demonstrated SCC arising from the lining of an OKC. Although the initial clinical and radiographic presentation suggested an infection or malignant neoplasm, biopsies revealed an infiltrative well-differentiated SCC contiguous with and arising from the focus of a pre-existing OKC. The patient subsequently underwent a type II hemi-maxillectomy with neoadjuvant chemoradiation. This report discusses the clinical and radiographic features associated with intraosseous malignancies, especially those arising from an otherwise benign odontogenic lesion. While the majority of OKCs are benign, the current report illustrates the potential for carcinomatous transformation within the lining of an OKC.
Biopsy ; Carcinoma, Squamous Cell* ; Cell Transformation, Neoplastic ; Epithelial Cells* ; Humans ; Maxilla ; Odontogenic Cysts*

An osteolytic lesion with a small central area of mineralization and sclerotic borders was discovered incidentally in the clivus on the cone-beam computed tomography (CBCT) of a 27-year-old male patient. This benign appearance indicated a primary differential diagnosis of non-aggressive lesions such as fibro-osseous lesions and arrested pneumatization. Further, on magnetic resonance imaging (MRI), the lesion showed a homogenously low T1 signal intensity with mild internal enhancement after post-gadolinium and a heterogeneous T2 signal intensity. These signal characteristics might be attributed to the fibrous tissues, chondroid matrix, calcific material, or cystic component of the lesion; thus, chondroblastoma and chondromyxoid fibroma were added to the differential diagnosis. Although this report was limited by the lack of final diagnosis and the patient lost to follow-up, the incidental skull base finding would be important for interpreting the entire volume of CBCT by a qualified oral and maxillofacial radiologist.
Adult ; Chondroblastoma ; Cone-Beam Computed Tomography* ; Cranial Fossa, Posterior ; Diagnosis ; Diagnosis, Differential ; Fibroma ; Humans ; Incidental Findings ; Lost to Follow-Up ; Magnetic Resonance Imaging ; Male ; Skull Base ; Skull Base Neoplasms