OBJECTIVETo investigate the effect of Rho-kinase inhibitor applied topically on the penile erection and systemic circulation of rats.

METHODSY-27632 was applied to the surface of the tunica albuginea or to the penile skin of rats, and the changes of CCP/MAP were observed continuously.

RESULTSBoth methods of drug administration resulted in a marked increase in the erectile response both with and without stimulation of the innervation of the penile vasculature. Some doses of the drug were also found to reduce systemic blood pressure.

CONCLUSIONInhibitors of Rho-kinase may represent a new and promising method of treatment for erectile dysfunction.

Amides ; pharmacology ; Animals ; Blood Pressure ; drug effects ; Enzyme Inhibitors ; pharmacology ; Male ; Penile Erection ; drug effects ; Pyridines ; pharmacology ; Rats ; Rats, Sprague-Dawley